HOME >> BIOLOGY >> NEWS
Gene linked to infertility in mice

DURHAM, N.C. -- A cell biologist at Duke University Medical Center has published a new study in mice that offers another possible genetic explanation for infertility in men: a gene called miwi.

The research has not yet been conducted using human tissue, but Haifan Lin, an associate professor of cell biology at Duke and senior author of the study, suspects that the human counterpart of miwi, called hiwi, is probably also associated with infertility in men. The study could eventually lead to genetic testing for the human form of the miwi gene, Lin said.

Piwi and miwi stem from the piwi family of genes known to be associated with the division of reproductive stem cells, which are the immature cells that can proliferate and mature to become adult sperm cells.

"This study presents the first definitive evidence that the piwi gene family has an essential function in the mammalian male reproductive system," said Lin, who is senior author of the paper in the June 7, 2002, issue of Developmental Cell.

In a related paper that appears in the June 6, 2002 issue of Oncogene, Lin describes the connection between the human homologue of piwi, called hiwi, and testicular cancer. (Please visit http://www.dukemednews.org for a news release featuring the Oncogene paper.)

There are a number of genes linked to male infertility, but only two, which includes miwi and crem, have been directly linked to sperm production as master regulators, Lin said.

When the miwi gene is defective or missing, it can lead to complete sterility in mice, he said.

"We show that this gene, miwi, instructs the making of a protein that binds to messenger RNAs to control their life span," Lin said. Messenger RNAs, which constitute the genetic instructions for proteins, are copied from DNA to be used to direct the cell's protein-making machinery.

"I
'"/>

Contact: Amy Reyes
a.reyes@duke.edu
919-668-7837
Duke University Medical Center
6-Jun-2002


Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
3. Protein involved in childhood disorder linked to cancer
4. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
5. Gene linked to cleft lip and palate identified
6. Schizophrenia gene variant linked to risk traits
7. Gene changes linked to increased eye pressure may have implications for glaucoma therapy
8. Excess levels of nitrogen, phosphorus linked to deformed frogs
9. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
10. LBP-1a gene mutation linked to disruption of normal fetal development
11. Outcome for acute lymphoblastic leukemia linked to gene expression patterns

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... FREDERICK, Md. (PRWEB) , ... ... ... a leading provider of gene-to-protein and monoclonal antibody development services, today announced ... of protein-based products and services to the pharmaceutical, diagnostics, and research industries. ...
(Date:6/23/2020)... ... ... The field of quantitation of large molecules or proteins has been around for a ... of mass spectrometry in this field has gained a lot of momentum in the ... approach to use (LBA or MS)?” In many cases, either technology can answer ...
(Date:6/23/2020)... ... June 23, 2020 , ... In its June 22 online post, business and ... L. Sherley, M.D., Ph.D., founder and director of stem cell biotechnology company Asymmetrex ... 16 that starting July 5 it would begin offering free tissue stem ...
Breaking Biology News(10 mins):
(Date:6/28/2020)... ... ... The Indoor Lab, a leading provider of sensor solutions for monitoring foot ... ensure cleanliness, distancing and occupancy with its patent pending WipeAway™ technology using Artificial Intelligence ... a health performance index system that scores all aspects of compliance similar to the ...
(Date:6/28/2020)... ... June 26, 2020 , ... The Security Industry Association ... strong opposition to the recently introduced bicameral Facial Recognition and Biometric Technology ... federal use of nearly all biometric and related image analytics technologies, incorrectly labeling ...
(Date:6/23/2020)... ... 22, 2020 , ... Regen Suppliers, the one stop shop ... three, get the fourth unit free with no limit on the amniotic derived ... exosomes, have been a game changer for regenerative therapies. The products are manufactured ...
(Date:6/19/2020)... (PRWEB) , ... June 18, 2020 , ... The ... Its goal is to join forces to radically prolong life and find a way ... the aging period. This project was supported by various scientists from all over the ...
Breaking Biology Technology:
Cached News: