HOME >> BIOLOGY >> NEWS
Gene located for rare fat disorder

DALLAS - September 14, 1999 - An international team led by researchers at UT Southwestern Medical Center at Dallas has located the gene for a rare fat-developmental disorder called congenital generalized lipodystrophy.

Lipodystrophy disorders cause selective loss of body fat and are associated with the same metabolic complications as obesity - lipid disorders and diabetes.

The researchers reported finding the location of a gene that causes congenital generalized lipodystrophy in the September issue of the Journal of Clinical Endocrinology and Metabolism. The work was done by Dr. Abhimanyu Garg, professor of internal medicine at UT Southwestern, former UT Southwestern faculty member Dr. Anne Bowcock, now at the Washington University School of Medicine in St. Louis, colleagues from UT Southwestern and researchers from the National Institutes of Health (NIH), Pakistan, Turkey and the United Kingdom.

Congenital generalized lipodystrophy is the most severe form of the lipodystrophies. It is characterized by a lack of body fat from birth. Patients appear extremely muscular and have little fat. They develop severe insulin resistance, and diabetes occurs during teen-age years. They also have high triglyceride levels and low levels of HDL cholesterol- the "good" cholesterol.

The researchers collected genetic data on 17 families from around the world with congenital generalized lipodystrophy. The gene for the disorder was found on the long arm of chromosome 9, and studies are under way to isolate the gene. Research indicates a second gene may be implicated in congenital generalized lipodystrophy. The second gene has not yet been located or identified.

This breakthrough comes 45 years after the initial description of the disorder.

"Locating a gene for congenital generalized lipodystrophy certainly opens doors for investigation into common obesity," Garg said. "If we can find out why these genetic defects cause loss of fat and complications associat
'"/>

Contact: Bridgette Rose McNeill
bridgette.mcneill@email.swmed.edu
214-648-3404
UT Southwestern Medical Center
14-Sep-1999


Page: 1 2

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. A genetic disorder yields insight into genes and cognition
3. Protein involved in childhood disorder linked to cancer
4. Genetic clues found for common congenital brain disorder
5. Brain serotonin enzyme finding might explain psychiatric disorders
6. Earliest evidence of hereditary genetic disorder discovered by Hebrew University researchers
7. New study confirms process leading to disorder causing male characteristics in women
8. Brain development and puberty may be key factors in learning disorders
9. Gene therapy with growth factor seems promising therapy for incurable muscle disorder ALS
10. Scientists track protein linked to movement disorder
11. Motion that powers sperm provides key to unravelling rare genetic disorder

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... -- Veratad Technologies, LLC ( www.veratad.com ), an innovative and ... solutions, announced today they will participate as a sponsor ... May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions of ... digital world, defining identity is critical to nearly every ...
(Date:5/6/2017)... SINGAPORE , May 5, 2017 ... has just announced a new breakthrough in biometric ... that exploits quantum mechanical properties to perform ... new smart semiconductor material created by Ram Group ... across finance, entertainment, transportation, supply chains and security. ...
(Date:4/19/2017)... , April 19, 2017 ... its vendor landscape is marked by the presence of ... is however held by five major players - 3M ... these companies accounted for nearly 61% of the global ... leading companies in the global military biometrics market boast ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 system ... experiments and avoiding the use of exogenous expression plasmids. The simplicity of programming ... systematic gain-of-function studies. , This complement to loss-of-function studies, such as with ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for ... June 2018 in San Francisco, CA. The Summit brings together current and former FDA ... board directors and government officials from around the world to address key issues in ...
(Date:10/11/2017)... -- VMS BioMarketing, a leading provider of patient support solutions, has ... (CNE) network, which will launch this week. The VMS CNEs ... professionals to enhance the patient care experience by delivering peer-to-peer ... care professionals to help women who have been diagnosed and ... ...
(Date:10/11/2017)... ... ... Disappearing forests and increased emissions are the main causes of the evolving ... those living in larger cities are affected by air pollution related diseases. , That ... countries globally - decided to take action. , “I knew I had to take ...
Breaking Biology Technology:
Cached News: