HOME >> BIOLOGY >> NEWS
Gene newly identified by Columbia researchers may improve hair removal

Researchers at Columbia University are uncovering the mechanisms of previously unknown genes governing hair growth and cycling. In their latest findings, published in the April 18 edition of Cell , they identified a new gene that encodes an adhesion protein crucial for hair growth. The findings could lead to better, longer-lasting hair-removal treatments, the researchers say, and might someday shed light on baldness.

The newly discovered protein, called desmoglein 4 (DSG4), holds cells together as they change into one of many different types of hair follicle cells. DSG4 ensures that each cell is in the right place at the right time as it marches alongside the others when the hair shaft is formed. This way, each cell receives the right signals to become the right type of hair cell.

This protein is like the Velcro that holds the cells together. If they dont stick together properly, they become disconnected from their neighbors and cant receive instructions properly, says Dr. Angela M. Christiano, associate professor of dermatology and genetics & development at Columbias College of Physicians & Surgeons, in whose laboratory the research was performed.

Without DSG4, the cells separate from each other and become disorganized, and rather than the six ordered layers of a normal hair fiber, you get a cluster of confused cells in the hair follicle. As a result, people and mice lacking the gene have thin, sparse hair that is fragile and breaks easily.

The gene, DSG4, is the third found in Dr. Christianos laboratory to have a role in human hair growth. Its the first of the three that codes for a structural protein, meaning it creates a product that becomes part of the bricks and mortar of the hair follicle. The other two are regulatory genes, meaning that rather than produce a structural protein, they are switch genes that turn other genes on and off.

In a sense, Dr. Christiano says, this is the first hardware gene. The ot
'"/>

Contact: Leslie Boen
lsb2001@columbia.edu
Columbia University Medical Center
6-May-2003


Page: 1 2

Related biology news :

1. Millennia still mean early days for newly identified sex chromosome
2. Bodys internal clock is set by newly discovered light detection system in the eye
3. A newly identified learning and memory area in the human brain
4. PET changes staging and treatment for newly diagnosed and recurrent lung cancer patients
5. Rare childhood genetic syndrome identified
6. Newly identified master gene key in babys first breath
7. Key stimulator of colorectal cancer identified
8. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
9. A probable cause for high blood pressure identified - shows links with diabetes
10. Gene associatied with lupus identified
11. Gene linked to cleft lip and palate identified

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2019)... ... April 17, 2019 , ... Quartesian LLC, a full-service contract ... sponsors, has entered into a multi-year agreement with Medrio, a leading provider of ... Medrio’s Certified Partner Program, to leverage the full range of Medrio’s products including ...
(Date:4/16/2019)... ... April 16, 2019 , ... The ... two signature events: The 2019 ISPE Biopharmaceutical Manufacturing Conference , on 18–20 ... Taking place in one of the most influential bio hubs, Boston, Massachusetts USA, ...
(Date:4/9/2019)... S.C. (PRWEB) , ... April 09, 2019 , ... The ... Novalis Certified Cancer Center following a rigorous and voluntary audit conducted by an ... One of only eight Novalis Certified Centers in the United States, McLeod is the ...
Breaking Biology News(10 mins):
(Date:4/9/2019)... ... , ... The American Society of Gene & Cell Therapy (ASGCT) ... new addition to the presidential line of succession, at the 22nd Annual Meeting ... team for a three-year term (2019-2021). , All five incoming members of the ...
(Date:4/4/2019)... ... April 03, 2019 , ... LeadingBiotech, an ... and dialogue, today announces its Boston CEO conference to be held May 28-29, ... challenges and opportunities with high-level panels and discussions from past, present and future ...
(Date:3/23/2019)... ... March 22, 2019 , ... uBiome has awarded ... team of researchers at Nnamdi Azikiwe University in Anambra State, Nigeria led by ... of the Department of Medical Laboratory Sciences and Deputy Provost, College of Health ...
(Date:3/19/2019)... ... March 19, 2019 , ... Konica Minolta Precision ... the formation of their inaugural Scientific Advisory Board. , Founded in ... into account individual variability in genes, environment, and lifestyle to more accurately predict, ...
Breaking Biology Technology:
Cached News: