HOME >> BIOLOGY >> NEWS
Gene profiling reveals the essence of 'stemness'

An extensive genetic comparison of different types of stem cells and terminally differentiated cells has revealed that hundreds of genes are likely to be involved in shaping the characteristic properties of stem cells. The studies show that embryonic, neural and hematopoietic (blood-cell-forming) stem cells seem to share a common genetic program that may be important for "stemness."

These initial gene-profiling studies provide basic information about the nature of stem cells that should aid long-term efforts to induce stem cells to differentiate into cells that can be used to replace tissue damaged by disease or trauma.

Howard Hughes Medical Institute investigator Douglas A. Melton and his colleagues at Harvard University described their findings in an article in the September 12, 2002, issue of Science Express, which provides rapid electronic publication of select articles that will appear in the journal Science.

"There has been a great deal of excitement about the possibility that adult stem cells are entirely plastic, that is, they are able to become any tissue in the body," said Melton. "However, there have been questions about whether such conclusions were correct. This led us to wonder if we could figure out whether stem cells were, in fact, all similar. And a related and critical scientific question is what genes or genetic programs are important for stem cells to have their special properties, or 'stemness.'"

To get at the answers to those questions, Melton and his colleagues developed experiments to survey thousands of genes in different kinds of stem cells and mature cells to determine if there are patterns of gene activity that are distinct to stem cells.

"We were quite stringent in our criteria for which stem cells to look at, choosing only those that everyone agreed were, indeed, stem cells," said Melton. The scientists compared embry
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
12-Sep-2002


Page: 1 2 3

Related biology news :

1. Gene expression profiling may predict head, neck cancer recurrence
2. UCLA study uses genetic profiling to distinguish types of leprosy
3. DNA profiling is subject of two-day expert forum at Wright State
4. DNA profiling used on cannabis plants
5. Fish profiling to stop ANS; dye test for fish disease; reauthorization
6. Breakthrough in profiling of yeast genome
7. Diagnosis on a chip - molecular profiling that could improve diagnosis and help design better drugs
8. Hidden diversity: DNA barcoding reveals a common butterfly is actually 10 different species
9. Brown research reveals key insight into memory-making
10. Study reveals why eyes in some paintings seem to follow viewers
11. New dye directly reveals activated proteins in living cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/19/2019)... ... February 18, 2019 , ... ... delivery technologies and development solutions for drugs, biologics and consumer health products, ... highest external business partner recognition, the External Business Partner of the Year ...
(Date:2/19/2019)... ... 18, 2019 , ... The Idea, Emma came home from her first day of elementary school ... must be an app out there to make her homework a little more fun. Unable ... Words. , The idea is simple enough: help children learn the vocabulary they see in ...
(Date:2/14/2019)... N.J. (PRWEB) , ... February 14, 2019 , ... ... together over 315 companies from around-the-world and will host 80 scientific sessions and ... the toxicology research space, Visikol will feature its OpenLiver™ 3D cell culture ...
Breaking Biology News(10 mins):
(Date:2/16/2019)... TORONTO (PRWEB) , ... February 14, 2019 , ... ... data visualization, analytics, and knowledge sharing capability that also provides the flexibility for ... and play” functionality. It also provides a shared workbench to conduct quick analytics ...
(Date:2/14/2019)... ... February 14, 2019 , ... Leak Detection Associates ... pharmaceutical, biotechnology and food industries, formally announced today the appointment of two key ... been named Chief Executive Officer and will oversee all aspects of the company’s ...
(Date:2/12/2019)... ... 2019 , ... Innovaderm Research, Inc., an innovative clinical research ... of Medrio, the leading provider of eClinical technology for early-phase pharma, medical device, ... customer for over nine years, primarily using the software in Phase I, Phase ...
(Date:2/6/2019)... ... February 05, 2019 , ... Firmex announced today that VERTU ... acquire Firmex, one of the fastest-growing and most widely-used providers of virtual data ... Debt financing was provided by the Bank of Montreal. , Headquartered in Toronto, ...
Breaking Biology Technology:
Cached News: