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Gene raises risk of neurodevelopmental problems after infant heart surgery

Philadelphia, Pa - Children with heart conditions who require surgery as infants may be more vulnerable to neurologic problems if they have a particular variety of a gene.

The gene variant may decrease the ability of neurons to repair themselves following open heart surgery, with the result that children score lower on neurodevelopmental tests at age one. The researchers, from The Children's Hospital of Philadelphia, presented findings at the Scientific Sessions of the American Heart Association today in Orlando, Fla. Cardiothoracic surgeon J. William Gaynor, M.D., presented the research.

Based on a one-year evaluation of 329 children who underwent surgery to repair a congenital heart defect at less than six months of age, the researchers found that children carrying the apolipoprotein E2 (APOE2) gene variant were significantly more likely to have worse outcomes in a developmental evaluation of cognitive and motor skills compared to children who underwent heart surgery and did not have the APOE2 gene. APOE2 occurs in approximately 8 percent of the population.

Apolipoprotein genes, which help to regulate how the body transports cholesterol in the blood, also have incompletely understood effects on neurons in the brain. The apolipoprotein E4 gene(APOE4) , which is more common than APOE2, has been studied in adults, for whom it confers a higher risk of suffering Alzheimer's disease and of recovering after brain injury. However, the researchers did not find that APOE4 had an effect on neurodevelopment in children in the study.

The researchers found the association between APOE2 and lower neurodevelopmental scores was consistent, even after they controlled for variables such as gestational age, age at surgery, ethnicity, socioeconomic status, type of cardiac defect, and surgical techniques.

The Cardiac Center at The Children's Hospital of Philadelphia is a comprehensive center for the care of infants, children and young adults wi
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Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
10-Nov-2003


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