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Gene responsible for aging found in yeast

Could yeast show us the secrets to the aging process? Researchers have discovered that the secret to slowing the aging process in yeast is calorie restriction and have also identified the gene involved, a finding that could have potential for the development of anti-aging therapies. They report their research today at the 100th General Meeting of the American Society for Microbiology.

Caloric restriction, which is the reduction of caloric intake without malnutrition, is a time proven method for extending the life span of mammals and postponing the manifestations of aging, including both functional decline and age-related diseases. Much is know about the physiological changes that occur in animals subjected to caloric restriction, but molecular mechanisms involved in this phenomenon are poorly understood because of the lack of workable experimental models.

"The efficacy of caloric restriction in retarding the aging process points to the importance of nutritional and metabolic mechanisms in aging," says Dr. Michal Jazwinski of the Louisiana State University. "If we could elucidate these mechanisms, it is likely that we would be able to develop relatively simple interventions that would alleviate the ravages of the aging process and improve quality of life in the later years in humans."

Dr. Jazwinski has developed the yeast Saccharomyces cerevisiae as an experimental model for the molecular analysis of the aging process. He has discovered that manipulating the nutritional intake of yeast cells can increase their life spans, providing a useful model for the molecular analysis of caloric restriction. Not only has Dr. Jazwinski shown that caloric restriction extends the life span of these cells but also postpones many of the physical manifestations of aging.

In a related study, Dr. Leonard Guarente of the Massachusetts Institute of Technology announced that his lab has identified a gene, SIR2, which regulates the life span of yeast. The gene is
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Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
23-May-2000


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