HOME >> BIOLOGY >> NEWS
Gene that directs fate of many embryonic stem cells identified

Scientists have identified the gene that prompts embryonic stem cells to generate precursors to most internal organs. The finding suggests a potent new way of coaxing stem cells to produce high numbers of specialized cells that can form medically needed tissues such as insulin-producing pancreatic cells, the scientists say.

The research led by University of California, San Francisco scientists is based on studies of zebrafish, an animal that has become a powerful model of early human embryo development. Strong evidence indicates that the pivotal gene plays the same role in humans as it does in zebrafish: inducing embryonic stem cells to produce endoderm, the source material for many specialized cells and tissues, including the pancreas, liver, thymus and thyroid.

"Exploiting this master gene, we can control stem cell differentiation from the inside, as opposed to trying to boost differentiation from the outside with growth factors," said Didier Stainier, PhD, UCSF associate professor of biochemistry and biophysics and senior author on a paper reporting the research. The study is published in the June 15 issue of Genes and Development.

Embryonic stem cells are the focus of intense research interest because their ability to give rise to all tissues of the body make them a potentially vital player in regenerative medicine.

The researchers dubbed the master gene they isolated casanova because mutant animals lacking the gene have a split heart. Casanova or cas, the team found, is essential and sufficient to prod embryonic stem cells into making endodermal cells. These, in turn, give rise to many internal organs, as well as the lining of the lungs and gut.

Ambitious new efforts to restore the insulin-producing capacity in people with type 1 diabetes rely on injections of insulin-producing beta cells. But the supply of these cells is severely limited. Endoderm gives rise to these beta cells, and also to the liver's hepatocytes. By
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
14-Jun-2001


Page: 1 2 3

Related biology news :

1. Molecular traffic cop directs cellular signals
2. Crowding stem cells personal space directs their future
3. First molecule discovered that directs nerve cells to connect with each other
4. Sequential signals choreograph embryonic tubule formation
5. Therapeutic cloning no longer a dream, says scientist who produced first cloned embryonic stem cell
6. Conflicting views on embryonic and adult stem cells complicate research in stem cell therapeutics
7. MIT technology jump-starts human embryonic stem cell work
8. New human embryonic stem-cell lines to be made available to researchers
9. Human embryonic stem cells may promise medical advances
10. Feeder-free system for maintaining pluripotency in embryonic stem cells pioneered
11. Mouse embryonic germ cells and male gametes created in the lab

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/11/2020)... ... May 11, 2020 , ... ... platform for patients with implanted cardiac devices. The Octagos software allows healthcare professionals ... The software greatly simplifies the management of remote transmissions and at the same ...
(Date:5/6/2020)... ... May 06, 2020 , ... The LaunchPort™ ... the latest out-of-state company to partner with the device accelerator located in ... a point-of-care analyzer capable of accurately performing enzyme-linked immunosorbent assays (ELISAs), the ...
(Date:5/1/2020)... ... 2020 , ... Flagship Biosciences , providers of expert ... and regulatory services advisor. The companies now deliver regulatory strategy and support to ... a collaborative approach to empower more confident and informed regulatory decisions through every ...
Breaking Biology News(10 mins):
(Date:5/14/2020)... WILMINGTON, Del. (PRWEB) , ... May 12, 2020 ... ... selection of Interdisp JCS as the new distribution partner for all personal care ... the DuPont GENENCARE®OSMS portfolio and DuPont preservative portfolio for personal care. , ...
(Date:5/14/2020)... ... May 13, 2020 , ... ... or phenotypic readouts, providing little or no information on the drug’s mechanism of ... comprehensive characterization of compounds by measuring the activity of molecular pathways. This information ...
(Date:5/5/2020)... ... May 05, 2020 , ... ProductLife Group has marked ... Duburcq joins the group after 13 years at Altran, where he was Group VP ... in Immunology and being a Pharmacist, Xavier was involved in his early career in ...
(Date:4/26/2020)... ... April 23, 2020 , ... Indegene Omnipresence, Inc. announced ... applications and services for use on Microsoft Azure. The customer experience management (CXM) ... online for a built-for-purpose customer engagement capability to use in their commercial or ...
Breaking Biology Technology:
Cached News: