HOME >> BIOLOGY >> NEWS
Gene that regulates development of heart cells identified, described by Penn researchers

(Philadelphia, PA) -- Scientists at the University of Pennsylvania School of Medicine have identified and described a small gene that regulates the delicate balance involved in the healthy growth and replication of heart muscle cells.

"This finding is likely to be important for our understanding of the causes of congenital heart disease. It is also relevant to our attempts to regrow damaged heart muscle," said the corresponding author of the study, Jonathan A. Epstein, MD, of Penn's Departments of Medicine and Cell & Developmental Biology. The study is scheduled to appear in the September 20 issue of the journal Cell.

The newly identified heart gene, Hop (an acronym for homeodomain only protein), is a small protein that lacks certain residues required for DNA binding, but is activated early in fetal development and continues modulating the expression of cardiac-specific genes throughout life. Hop appears to bind directly to another important regulator of development, serum response factor (SRF), and block SRF from binding to DNA. By inhibiting the expression of SRF, Hop protects cardiac muscle cells from over-development, and from developing fatal abnormalities.

"There has been a lot of effort to try to determine how SRF is regulated in different tissues," Epstein said. "Now we see that Hop plays a vital part."


'"/>

Contact: Ellen O'Brien
ellen.obrien@uphs.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
19-Sep-2002


Page: 1

Related biology news :

1. Researchers reveal calcium transport protein function that regulates heartbeat frequency, strength
2. Reward mechanism involved in addiction likely regulates pair bonds between monogamous animals
3. UBC researcher discovers control room that regulates immune responses
4. Progesterone regulates male behavior toward infants
5. Researchers identify protein that regulates killer cells
6. Scientist detail how brain regulates sensory information
7. Researchers identify key gene that regulates immune response
8. Wishful thinking gene regulates neural development
9. Images reveal how body regulates salt uptake in cells
10. Researchers discover thermostat that regulates bone density
11. Mechanism believed found that regulates movement within cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2019)... , ... February 13, 2019 , ... ... the Boston operations of London based Vinelake Ltd. which includes four annual ... Insurance and two on Internet of Manufacturing. , Phillips Kuhl, President, Cambridge Innovation ...
(Date:2/11/2019)... (PRWEB) , ... February 11, 2019 , ... ... DNA analysis products and services, announced a new forensic genealogy service offering to ... combines advanced DNA testing and genealogy to develop ancestral relationships between samples ...
(Date:2/2/2019)... ... 2019 , ... Through its Microbiome Grant Initiative , ... design, planning, sample collection, and analysis to researchers at Stanford University led by ... Vaughn, MD, Reproductive Endocrinology and Infertility Fellow, to study the role of abnormal ...
Breaking Biology News(10 mins):
(Date:1/30/2019)... ... January 30, 2019 , ... The Society for ... agencies to discuss best practices for laboratory automation and screening. This year the ... this year’s conference, Visikol will be at booth #345 and throughout the conference ...
(Date:1/28/2019)... DIEGO (PRWEB) , ... January 28, 2019 , ... ... against libraries of low molecular weight compounds. In this early stage, false positives ... At the same time, it is vital that screening techniques are highly sensitive ...
(Date:1/24/2019)... , ... January 22, 2019 , ... ... each trial has its own set of assumptions, and RFP creation and management ... evaluating bids is like comparing apples to oranges. These challenges can ultimately lead ...
(Date:1/20/2019)... ... ... On January 15 of this year, the Parents’ Guide to Cord Blood website ... M.D., Ph.D. The PGCB was founded by former physicist Dr. Frances Verter, who ... 21st year of operation, the PGCB continues its mission to educate parents with accurate ...
Breaking Biology Technology:
Cached News: