HOME >> BIOLOGY >> NEWS
Gene therapy technique reduces alcohol consumption in rats

Scientists at the U.S. Department of Energy's Brookhaven National Laboratory report in the current Journal of Neurochemistry (Volume 78, Number 5) that they used gene therapy techniques to increase levels of dopamine D2 (DRD2) receptors and reduce drinking in rats previously trained to self-administer alcohol. Panayotis Thanos, Ph.D., Nora Volkow, Ph.D., and colleagues used a partially inactivated virus as a vector, or transport agent, to carry copies of the DRD2 gene to the rat nucleus accumbens, the brain area associated with the reinforcing effects of alcohol. Supplying copies of the gene in this manner enables the rat brain cells to manufacture larger amounts of DRD2 receptors than they would ordinarily.

Strong evidence from pharmacologic studies in both humans and animals indicates that the dopamine pathway plays a major role in brain reward circuits, the function of which is altered by addiction. Whereas a drink of alcohol increases immediate brain production of dopamine (a chemical messenger, or neurotransmitter, involved in locomotion, alcohol reward, and the compulsion to drink) chronic drinking has been associated with decreased dopamine activity in rodents and with low levels of dopamine and its metabolites in humans. In 1996, Dr. Volkow and others showed that DRD2 receptors are depleted in human alcoholics. Whereas behavioral effects of this depletion are unclear, Drs. Thanos and Volkow hypothesize that DRD2 depletion produces a blunted pleasure response that leads alcoholics to increase their intake.

The research team performed two experiments for the current study-one to evaluate the rats' DRD2 receptor levels and one to evaluate drinking behavior at different time points following the DRD2 gene injection. To determine whether receptor levels had increased, they used a signal-emitting system designed to bind to the receptors and detected the signals in brain images known as autoradiographs. The strength of the signals indicated that ra
'"/>

Contact: Ann Bradley
abradley@willco.niaaa.nih.gov
301-443-0595
NIH/National Institute on Alcohol Abuse and Alcoholism
13-Sep-2001


Page: 1 2

Related biology news :

1. Targeted therapy knocks out pediatric brain cancer in mice
2. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
3. Columbia research to examine gene influence on severity of peridontal disease, therapy response
4. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
5. The search for a kinder, gentler chemotherapy
6. Embryonic stem cell therapy shows steady benefits in rebuilding infarcted heart
7. Retroviral gene therapy? ASLV, HIV, and MLV show distinct target site preferences
8. Gene changes linked to increased eye pressure may have implications for glaucoma therapy
9. Jefferson Lab detector technology aids development of cystic fibrosis therapy
10. Stroking up cellular therapy
11. Smart gene therapy protects against damage from heart attack

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2020)... (PRWEB) , ... February 06, 2020 , ... ... to facilitate access to unique lab-made bioresearch materials, today announced an agreement with ... and plant-based meat and seafood a reality. Under the partnership, terrestrial meat and ...
(Date:2/5/2020)... ... February 05, 2020 , ... LabKey has ... efficiency and insight to sample processing within laboratories. , Built with input ... research in various fields, LabKey Sample Manager has been designed with an intuitive ...
(Date:1/30/2020)... (PRWEB) , ... January 30, 2020 , ... Accelera ... an eye on the Canadian market, is pleased to announce that the company has ... growth since the company launched in 2017. , “We are so thrilled to ...
Breaking Biology News(10 mins):
(Date:1/24/2020)... Calif. (PRWEB) , ... January 24, 2020 , ... ... launch of their RedySmart™ mass flow meters and controllers ideal for ... as an ideal upgrade to antiquated rotameters. These thermal instruments employ high-precision MEMS ...
(Date:1/22/2020)... FARMINGTON, Conn. (PRWEB) , ... January 21, 2020 , ... ... Cell (CTC) liquid biopsy from a simple blood draw, today announced the sale of ... UConn Health. The Rare Scope will be used in clinical cancer research. , “The ...
(Date:1/8/2020)... ... January 08, 2020 , ... ... helps couples and individuals grow their family, has announced that five of their ... Castle Connolly. Since 1991, the renowned publishing company Castle Connolly has ...
(Date:1/7/2020)... ... 2020 , ... ABCT , the Accelerator for Biosciences ... participate in the annual program. Twelve ventures will participate in the 6.5-month-long program ... All startups will receive an entrepreneur coach, access to active business professionals and ...
Breaking Biology Technology:
Cached News: