HOME >> BIOLOGY >> NEWS
Gene transfer improves function of aging hearts in animals

etimes into the lungs. Heart failure is a growing health problem in the developed world, with more than 400,000 people being diagnosed in the U.S. each year. While deaths from coronary heart disease have decreased in recent years, heart failure deaths are on the rise - more than doubling from 1979 to 1995.

With true heart failure, the weakened heart muscle functions poorly throughout the entire heartbeat cycle - both in the contraction (systolic) phase and in the relaxation (diastolic) phase. However, in a significant number of older people (40 percent of those over 60), the heart contracts normally but the relaxation phase is abnormal, a problem called diastolic dysfunction. These patients exhibit some symptoms of congestive heart failure and many proceed to the complete syndrome.

It is well known that failing hearts do not properly handle calcium, a mineral that plays a key role in the contraction of any muscle cell. Inside the cell, calcium is stored in a structure called the sarcoplasmic reticulum (SR); when it is released in response to the appropriate signals, calcium causes muscle cells to contract. After contraction, calcium returns to the SR via a molecular calcium pump, the SERCA2a protein. Earlier research at the MGH and elsewhere strongly suggested that decreased function of the SERCA2a pump was linked to heart failure and to diastolic dysfunction. While recent studies support the hypothesis that increasing expression of the SERCA2a gene could improve the function of a failing heart, whether the same strategy could alleviate diastolic dysfunction had not yet been tested.

In the current study, additional copies of the SERCA2a gene inserted into a standard experimental viral vector were delivered directly into the hearts of aged rats (26 months old) via a surgically implanted catheter. Three other groups of rats were used for comparison purposes: aged rats that underwent a similar operation without receiving a vector; aged rats tha
'"/>

Contact: Susan McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
21-Feb-2000


Page: 1 2 3

Related biology news :

1. Groundbreaking research could ignite new solutions to heat transfer in nano-devices
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. The protection of human subjects in gene transfer research explored at conference in July
4. Gene transfer allows mammals to produce heart-healthy fats
5. ORNL earns top Southeastern laboratory technology transfer award
6. Amphibians life stages influence contaminant transfer from aquatic to terrestrial environments
7. Success and single embryo transfer in IVF
8. VEGF gene transfer fails to help peripheral arterial disease patients
9. Sertoli cell transfer restores sperm production in infertile mice
10. New method used to transfer genes into mouse
11. High tech movies reveal information transfer within cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/30/2017)... Jan. 30, 2017   Invitae Corporation (NYSE: ... genetic information companies, today announced that it will report ... provide 2017 guidance on Monday, February 13, 2017, and ... day at 4:45 p.m. Eastern / 1:45 p.m. Pacific. ... will briefly review financial results, guidance, and recent developments ...
(Date:1/24/2017)... PHILADELPHIA , Jan. 24, 2017  It ... a baby,s sock that monitors vital signs and ... instance, an infant,s oxygen saturation level drops. But ... undue alarm to parents, with no evidence of ... "These devices are marketed aggressively to parents of ...
(Date:1/18/2017)... ROCKVILLE, Md. , Jan. 18, 2017  In ... with respect to mergers and acquisitions (M&A), and Kalorama ... reasons for such acquisitions have been shifting. Generally, uncertainty ... and the U.S. has changed the acquisitions ... situation has resulted in companies buying partners outside of ...
Breaking Biology News(10 mins):
(Date:2/18/2017)... 2017 Kurzlehrgang mit Fokus ... Zelltherapie-Studien, Poster legt metaproteomische Analyse des Darm-Mikrobioms bei Säuglingen ... ... Dr. Yoav Peretz , Scientific Director bei ImmuneCarta, ... Assays zum Nachweis intrazellulärer Zytokine bei adoptiven Zelltherapie-Studien im ...
(Date:2/18/2017)... ... February 17, 2017 , ... ... business in Hong Kong. , Nerium International is proud to introduce its Age-Defying ... Contour Cream, NeriumAD™ Formula to consumers across Hong Kong. The luxury skincare products ...
(Date:2/17/2017)... PUNE, India , February 17, 2017 /PRNewswire/ ... research report "Biomarkers Market by Product (Consumables, Service), ... Disorders), Application (Diagnostics Development, Drug Discovery and Development, ... MarketsandMarkets, the market is projected to reach USD ... in 2016, growing at a CAGR of 13.8% ...
(Date:2/17/2017)... 17, 2017  If only one in every ... mutation-conferring resistance to chemotherapy, thousands of cancer cells ... focused on finding these mutations in ever-smaller subpopulations ... tumor DNA in blood — to guide treatment ... Unfortunately, however, detecting these genetic anomalies may ...
Breaking Biology Technology:
Cached News: