HOME >> BIOLOGY >> NEWS
Gene transfer improves function of aging hearts in animals

etimes into the lungs. Heart failure is a growing health problem in the developed world, with more than 400,000 people being diagnosed in the U.S. each year. While deaths from coronary heart disease have decreased in recent years, heart failure deaths are on the rise - more than doubling from 1979 to 1995.

With true heart failure, the weakened heart muscle functions poorly throughout the entire heartbeat cycle - both in the contraction (systolic) phase and in the relaxation (diastolic) phase. However, in a significant number of older people (40 percent of those over 60), the heart contracts normally but the relaxation phase is abnormal, a problem called diastolic dysfunction. These patients exhibit some symptoms of congestive heart failure and many proceed to the complete syndrome.

It is well known that failing hearts do not properly handle calcium, a mineral that plays a key role in the contraction of any muscle cell. Inside the cell, calcium is stored in a structure called the sarcoplasmic reticulum (SR); when it is released in response to the appropriate signals, calcium causes muscle cells to contract. After contraction, calcium returns to the SR via a molecular calcium pump, the SERCA2a protein. Earlier research at the MGH and elsewhere strongly suggested that decreased function of the SERCA2a pump was linked to heart failure and to diastolic dysfunction. While recent studies support the hypothesis that increasing expression of the SERCA2a gene could improve the function of a failing heart, whether the same strategy could alleviate diastolic dysfunction had not yet been tested.

In the current study, additional copies of the SERCA2a gene inserted into a standard experimental viral vector were delivered directly into the hearts of aged rats (26 months old) via a surgically implanted catheter. Three other groups of rats were used for comparison purposes: aged rats that underwent a similar operation without receiving a vector; aged rats tha
'"/>

Contact: Susan McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
21-Feb-2000


Page: 1 2 3

Related biology news :

1. Groundbreaking research could ignite new solutions to heat transfer in nano-devices
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. The protection of human subjects in gene transfer research explored at conference in July
4. Gene transfer allows mammals to produce heart-healthy fats
5. ORNL earns top Southeastern laboratory technology transfer award
6. Amphibians life stages influence contaminant transfer from aquatic to terrestrial environments
7. Success and single embryo transfer in IVF
8. VEGF gene transfer fails to help peripheral arterial disease patients
9. Sertoli cell transfer restores sperm production in infertile mice
10. New method used to transfer genes into mouse
11. High tech movies reveal information transfer within cells

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene transfer improves function aging hearts animals

(Date:8/26/2014)... at the University of Illinois at Urbana-Champaign have ... paving the way for power-on-a-chip applications. , ... scale that amplify light and produce ultra-narrowband spectral ... electrical and computer engineering (ECE) at Illinois. "These ... power on a chip containing both electronic and ...
(Date:8/26/2014)... recommended investing in dog owner education and facilities as a ... in both people and their pets. , In a review ... access to dog-friendly walking environments and better education about dogs, ... take more exercise with their pets. , It is estimated ... a walk. In the UK, almost a quarter of households ...
(Date:8/25/2014)... the first U.S. outbreaks of the H1N1 virus swept ... people. A university math and biology professor has used ... gain insight into how only a few infected people ... community., The fall 2009 semester hadn,t even started when ... and Wellness Services clinic11 one day, and just two ...
Breaking Biology News(10 mins):Symphony of nanoplasmonic and optical resonators produces laser-like light emission 2Education and dog-friendly neighbourhoods could tackle obesity 2WSU flu outbreak provides rare study material 2WSU flu outbreak provides rare study material 3
(Date:8/27/2014)... According to the 2013 Raw Material ... look and feel of markets for raw materials and ... will push for more branded, science-backed products.” , Natural ... market growth in the last decade as consumers increasingly ... cosmetics to fit a more ‘wellness’ lifestyle approach. ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Budding ... Cleveland's University School participated in the ... Western Reserve University’s School of Medicine . ... with an unparalleled professional experience in the sciences ... of Medicine faculty and students for both academic ...
(Date:8/26/2014)... and Bellingham, WA (PRWEB) August 26, 2014 ... engineering, visions for next-generation wearable technology, and inspiration ... numerous highlights at this year’s brighter, busier ... Diego, California, Convention Center. More than 4,400 international ... attended conferences, courses, an exhibition, and industry sessions ...
(Date:8/26/2014)... team of engineers from Singapore has successfully piloted ... for satellite communications. , With the weight of ... constructing a lightweight, low power-consuming, wireless communication system ... has always been a challenge for system designers. ... Centre of Nanyang Technological University in Singapore launched ...
Breaking Biology Technology:Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 3Students at Cleveland's University School Conduct Biomedical Research at Case Western Reserve University’s School of Medicine 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4ZigBee in the Sky 2
Cached News: