HOME >> BIOLOGY >> NEWS
Gene treatment can boost heart function in rabbits, Duke researchers say

DURHAM, N.C. -- Scientists at Duke University Medical Center have delivered therapeutic genes throughout a rabbit's heart and have shown that the genes can both boost heart function on their own and also increase sensitivity to heart-stimulating drugs.

According to the researchers, the experiments, reported in the July 1 Journal of Clinical Investigation, are a crucial step in developing a genetic treatment for congestive heart failure. This debilitating and deadly condition develops when heart muscle loses its ability to stretch and contract, usually due to clogged arteries caused by coronary artery disease. People with congestive heart failure often experience fatigue, weakness and an inability to carry out routine daily tasks. There is currently no effective means to reverse heart failure, only to treat symptoms.

The research is funded by grants from the National Institutes of Health and the American Heart Association (AHA).

According to the AHA, about 400,000 new cases of congestive heat failure are recorded every year in the United States. Death rates from congestive heart failure tripled between 1974 and 1994, making it the leading cause of hospitalization among people 65 and older and costing more than $10 billion a year.

Research team leader Walter J. Koch, an associate professor of experimental surgery, and his colleagues have been working for several years to find ways to efficiently deliver genes to the heart to boost heart function.

In their experiments, the scientists first incorporated the therapeutic genes into a live but disabled common cold virus. Then, in a surgical technique that was a key to their success, the scientists injected the virus into the left ventricle of live rabbits while the aorta was clamped for a few seconds. This technique allowed the virus enough time to spread through all the coronary vessels to reach a majority of the heart muscle. Clamping the aorta is som
'"/>

Contact: Karyn Hede
Hede0001@mc.duke.edu
919-684-4148
Duke University Medical Center
30-Jun-1999


Page: 1 2 3 4

Related biology news :

1. Leader in cancer treatment and prevention research honored
2. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
3. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
4. New treatment for fibromyalgia
5. The impact of genetic variations on the treatment of early rheumatoid arthritis
6. OneWorld Health compiles comprehensive state of infectious diarrhea treatments, potential solutions
7. Early clinical treatment can halt progression of Alzheimers disease, UCI researchers find
8. Colleagues to recognize research leadership in cancer detection, prevention and treatment
9. New view of leukemia cells identifies best treatment options, Stanford researchers say
10. Genetic model for devastating form of paraplegia suggests new treatments
11. Protective mechanism exploited by tumors may provide new cancer treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2016)... 20, 2016  Synaptics Incorporated (NASDAQ: SYNA ... today announced sampling of S1423, its newest ClearPad ... small screen applications including smartwatches, fitness trackers, and ... and rectangular shapes, as well as thick and ... moisture on screen, while wearing gloves, and supports ...
(Date:1/11/2016)... , Jan. 11, 2016 Synaptics Incorporated ... interface solutions, today announced that its ClearPad ® ... (TDDI) products won two separate categories in the 8 ... Innovator and Best Technology Breakthrough. The Synaptics ® ... a simplified supply chain, thinner devices, brighter displays and ...
(Date:1/7/2016)... Jan. 7, 2016 Various factors have ... products such as biologics and biosimilars. Some of ... healthcare expenditure, growing demand for cost-effective alternatives, growing ... Biosimilars are similar versions of their corresponding patented ... their quality, safety, and efficacy. The global biosimilars ...
Breaking Biology News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016  In the pharmaceutical ... for a host of launch activities including the identification ... this launch activity is especially high in the oncology ... Best Practices and the Role of Medical Affairs ... companies focused on oncology therapies find better ways to ...
(Date:2/4/2016)... CA (PRWEB) , ... February 04, 2016 , ... ... enterprise talent development and compliance training, today announced an interactive FDA compliance ... Playbook™. The RAPS (Regulatory Affairs Professional Society) accredited interactive course on Morf ...
(Date:2/4/2016)... ... February 04, 2016 , ... ... Club, takes place February 5-6 at the University’s student center, Kehr Union, ... such as workshops and competitions for ample networking, learning and collaborating opportunities. ...
(Date:2/4/2016)... -- --> --> Q ... to provide the following update on recent corporate developments. ... 3 months we have significantly increased our cash position through ... a result, we have positioned ourselves to execute on the ... expect that development to continue on schedule. ...
Breaking Biology Technology:
Cached News: