HOME >> BIOLOGY >> NEWS
Gene treatment can boost heart function in rabbits, Duke researchers say

DURHAM, N.C. -- Scientists at Duke University Medical Center have delivered therapeutic genes throughout a rabbit's heart and have shown that the genes can both boost heart function on their own and also increase sensitivity to heart-stimulating drugs.

According to the researchers, the experiments, reported in the July 1 Journal of Clinical Investigation, are a crucial step in developing a genetic treatment for congestive heart failure. This debilitating and deadly condition develops when heart muscle loses its ability to stretch and contract, usually due to clogged arteries caused by coronary artery disease. People with congestive heart failure often experience fatigue, weakness and an inability to carry out routine daily tasks. There is currently no effective means to reverse heart failure, only to treat symptoms.

The research is funded by grants from the National Institutes of Health and the American Heart Association (AHA).

According to the AHA, about 400,000 new cases of congestive heat failure are recorded every year in the United States. Death rates from congestive heart failure tripled between 1974 and 1994, making it the leading cause of hospitalization among people 65 and older and costing more than $10 billion a year.

Research team leader Walter J. Koch, an associate professor of experimental surgery, and his colleagues have been working for several years to find ways to efficiently deliver genes to the heart to boost heart function.

In their experiments, the scientists first incorporated the therapeutic genes into a live but disabled common cold virus. Then, in a surgical technique that was a key to their success, the scientists injected the virus into the left ventricle of live rabbits while the aorta was clamped for a few seconds. This technique allowed the virus enough time to spread through all the coronary vessels to reach a majority of the heart muscle. Clamping the aorta is som
'"/>

Contact: Karyn Hede
Hede0001@mc.duke.edu
919-684-4148
Duke University Medical Center
30-Jun-1999


Page: 1 2 3 4

Related biology news :

1. Leader in cancer treatment and prevention research honored
2. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
3. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
4. New treatment for fibromyalgia
5. The impact of genetic variations on the treatment of early rheumatoid arthritis
6. OneWorld Health compiles comprehensive state of infectious diarrhea treatments, potential solutions
7. Early clinical treatment can halt progression of Alzheimers disease, UCI researchers find
8. Colleagues to recognize research leadership in cancer detection, prevention and treatment
9. New view of leukemia cells identifies best treatment options, Stanford researchers say
10. Genetic model for devastating form of paraplegia suggests new treatments
11. Protective mechanism exploited by tumors may provide new cancer treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... 2017  On April 6-7, 2017, Sequencing.com will host ... hackathon at Microsoft,s headquarters in Redmond, ... on developing health and wellness apps that provide a ... Genome is the first hackathon for personal genomics ... companies in the genomics, tech and health industries are ...
(Date:3/29/2017)... , March 29, 2017  higi, the health IT ... North America , today announced a ... the acquisition of EveryMove. The new investment and acquisition ... of tools to transform population health activities through the ... data. higi collects and secures data today ...
(Date:3/24/2017)... -- The Controller General of Immigration from Maldives Mr. ... have received the prestigious international IAIR Award for the most innovative high ... ... Maldives Immigration Controller ... (small picture on the right) have received the IAIR award for the ...
Breaking Biology News(10 mins):
(Date:6/23/2017)... ... June 23, 2017 , ... ... website for all six of their healthcare job boards. As the largest ... and occupational therapists, and biotechnicians, DocCafe.com and the MedJobCafe.com Health Network work ...
(Date:6/22/2017)... Colorado (PRWEB) , ... June 21, 2017 , ... ... RTP regional office in North Carolina, and engages Timothy Reinhardt to manage the ... of quality leadership at Pfizer Inc, with his most recent role as the ...
(Date:6/22/2017)... ... June 22, 2017 , ... Ovation Fertility ... as a disease, bringing new hope for prospective parents who are challenged with ... to back the World Health Organization’s designation in hopes of changing the way ...
(Date:6/22/2017)... ... June 22, 2017 , ... The first human cell line HeLa, established ... first data on cross-contamination of human cell lines with HeLa cells were published. Until ... cell culture labs and is associated with dramatic consequences for research. , In ...
Breaking Biology Technology:
Cached News: