HOME >> BIOLOGY >> NEWS
Gene trigger for pancreas formation identified

Before the pancreas is a pancreas, it is just two tiny bumps--two groups of cells sprouting from a central tube. What makes these cells bud off from the main group? How do they go on to make all the cell types of the mature pancreas? These are the kinds of questions that drive the research efforts of Vanderbilt developmental biologist Chris Wright and colleagues. The answers could pave the way toward limitless supplies of pancreatic cells for transplantation therapy of diabetes.

"It has been established that islet cell transplantation can solve the diabetes problem," said Wright, referring to studies carried out in Edmonton, Canada and elsewhere. "The problem is having a suitable and sufficient source of transplantation material."

Donated pancreases and the technical expertise required to isolate functioning islet cells--the pancreatic cells that produce insulin--will not meet the demand, Wright said. An alternative, he said, is to produce insulin-secreting cells from embryonic or other stem cells.

"If we can identify the factors that determine pancreatic cell fate," he said, "we might be able to coerce embryonic stem cells or other cells to turn into pancreas."

One of these factors is a gene called PTF1p48 (p48 for short). Wright and colleagues reported in Nature Genetics, published online August 19, that p48 is required for the development of the pancreas, both its exocrine cells--those that secrete digestive enzymes--and its endocrine cells--those that secrete insulin and other hormones.

Wright's team used what one reviewer of the paper called "a novel and powerful cell marking method" to track cells in the mouse that express the p48 gene, starting very early in embryonic pancreas formation. The method relied on genetic manipulations to introduce an inherited marker--a blue color that could be followed in cells that turned on the p48 gene, and in all the cells that came from those cells.

A simple way to thin
'"/>

Contact: John Howser
john.howser@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
18-Aug-2002


Page: 1 2 3

Related biology news :

1. Algal contact as a trigger for coral disease
2. Study suggests cell-cycle triggers might be cancer drug targets
3. Good bacteria trigger proteins to protect the gut
4. Inflammations trigger finger
5. Sick Kids researchers look at viral triggers for multiple sclerosis in children
6. Molecular mechanisms that trigger flowering in spring
7. Oxygen triggered the evolution of complex life forms
8. Ultra-low oxygen could have triggered die-offs, spurred bird breathing system
9. Retroviral protein triggers proliferation of immune cells
10. Collapse of seals, sea lions & sea otters in North Pacific triggered by overfishing of great whales
11. New compound class found to trigger changes in cell garbage can

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... 30, 2017 The research team of The ... (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery ... of speed and accuracy for use in identification, crime investigation, immigration ... ... A research team ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed Anwar ... prestigious international IAIR Award for the most innovative high security ePassport and ... ... Maldives Immigration Controller General, Mr. Mohamed ... the right) have received the IAIR award for the "Most innovative high ...
(Date:3/22/2017)... 21, 2017 Optimove , provider ... retailers such as 1-800-Flowers and AdoreMe, today announced ... and Replenishment. Using Optimove,s machine learning algorithms, these ... and replenishment recommendations to their customers based not ... of customer intent drawn from a complex web ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... June 22, 2017 , ... ... to clients throughout the biopharma and life sciences industries, continue to be in ... seeing. Tunnell’s Kip Wolf will be speaking on “The State of Information Governance ...
(Date:6/22/2017)... ... June 22, 2017 , ... Charm Sciences, Inc. is pleased ... test was determined to be appropriate as a screening test at dairies and farms ... Charm EZ system, and the Charm EZ Lite system. These systems are a combination ...
(Date:6/20/2017)... ... June 20, 2017 , ... HorizonScan ... adulterants which pose the most likely threat to their products at the annual ... , IFT's annual food expo attracts over 20,000 attendees representing food science ...
(Date:6/20/2017)... ... ... Do More with OHAUS , With the launch of the new laboratory equipment ... to extending its expertise across the entire laboratory to a range of life science ... for its customers to 'Do More' in the lab. , Efficiency and Safety ...
Breaking Biology Technology:
Cached News: