HOME >> BIOLOGY >> NEWS
Gene trigger for pancreas formation identified

Before the pancreas is a pancreas, it is just two tiny bumps--two groups of cells sprouting from a central tube. What makes these cells bud off from the main group? How do they go on to make all the cell types of the mature pancreas? These are the kinds of questions that drive the research efforts of Vanderbilt developmental biologist Chris Wright and colleagues. The answers could pave the way toward limitless supplies of pancreatic cells for transplantation therapy of diabetes.

"It has been established that islet cell transplantation can solve the diabetes problem," said Wright, referring to studies carried out in Edmonton, Canada and elsewhere. "The problem is having a suitable and sufficient source of transplantation material."

Donated pancreases and the technical expertise required to isolate functioning islet cells--the pancreatic cells that produce insulin--will not meet the demand, Wright said. An alternative, he said, is to produce insulin-secreting cells from embryonic or other stem cells.

"If we can identify the factors that determine pancreatic cell fate," he said, "we might be able to coerce embryonic stem cells or other cells to turn into pancreas."

One of these factors is a gene called PTF1p48 (p48 for short). Wright and colleagues reported in Nature Genetics, published online August 19, that p48 is required for the development of the pancreas, both its exocrine cells--those that secrete digestive enzymes--and its endocrine cells--those that secrete insulin and other hormones.

Wright's team used what one reviewer of the paper called "a novel and powerful cell marking method" to track cells in the mouse that express the p48 gene, starting very early in embryonic pancreas formation. The method relied on genetic manipulations to introduce an inherited marker--a blue color that could be followed in cells that turned on the p48 gene, and in all the cells that came from those cells.

A simple way to thin
'"/>

Contact: John Howser
john.howser@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
18-Aug-2002


Page: 1 2 3

Related biology news :

1. Algal contact as a trigger for coral disease
2. Study suggests cell-cycle triggers might be cancer drug targets
3. Good bacteria trigger proteins to protect the gut
4. Inflammations trigger finger
5. Sick Kids researchers look at viral triggers for multiple sclerosis in children
6. Molecular mechanisms that trigger flowering in spring
7. Oxygen triggered the evolution of complex life forms
8. Ultra-low oxygen could have triggered die-offs, spurred bird breathing system
9. Retroviral protein triggers proliferation of immune cells
10. Collapse of seals, sea lions & sea otters in North Pacific triggered by overfishing of great whales
11. New compound class found to trigger changes in cell garbage can

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene trigger for pancreas formation identified

(Date:6/24/2015)... 2015 Biometry authentication provider KeyLemon today ... solution one face in. Logo ... face in, entering the expanding biometric authentication market ... biometric answer to the password problem. With advanced ... with KeyLemon, one face in allows users to ...
(Date:6/23/2015)... GARDENS, Fla. , June 23, 2015 ... identity management and authentication solutions, today announced enhanced ... strong, multi-factor authentication solution.  The enhancements build ... use of the DigitalPersona Altus platform and ... reader compatibility. In today,s environment ...
(Date:6/17/2015)... Germany , June 17, 2015 ... today launched new Investigator ® STR assay kits for ... the United States . The new genetic fingerprint kits ... markers (short tandem repeats or STRs) for DNA matching. They ... quality of DNA in each sample, a novel QIAGEN technology ...
Breaking Biology News(10 mins):KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5
(Date:6/29/2015)... ... June 29, 2015 , ... ... around 19% during the forecast period (2015 to 2020). The market is mainly ... government and corporate funding for R&D. However, lack of adequate healthcare and research ...
(Date:6/29/2015)...  MiMedx Group, Inc. (NASDAQ: MDXG ), the ... patent-protected processes to develop and market advanced products and ... Medicine, Ophthalmic and Dental sectors of healthcare, announced that ... been awarded the Lifetime Achievement Award in the EY ... The Entrepreneur Of The Year Program, now in ...
(Date:6/29/2015)... ... June 29, 2015 , ... The StampedeCon ... and for the fourth year in a row, will bring top technology professionals to ... place at the intersection of data and technology. The event is proudly sponsored by ...
(Date:6/29/2015)... June 29, 2015 Elsevier ... information products and services, today announced the highlights of ... the 2014 Journal Citation Reports® (JCR) published by Thomson ... increase from 2013 to 2014, ahead of the aggregate ... top rank in 62 subject categories, up from 61 ...
Breaking Biology Technology:Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 2Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 3Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 4Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 5EY Entrepreneur Of The Year Program Recognizes Pete Petit, The Chairman & CEO of MiMedx 2StampedeCon Announces 2015 Agenda 2StampedeCon Announces 2015 Agenda 3Elsevier Announces 2014 Citation Impact Highlights 2Elsevier Announces 2014 Citation Impact Highlights 3
Cached News: