Gene triggers stem cell differentiation in the intestine

A gene that governs development of neuronal cells has now been shown to be involved in regulating differentiation of stem cells into secretory cells in the intestine.

The research team, which included Howard Hughes Medical Institute investigator Huda Zoghbi, Qi Yang, Nessan Bermingham and Milton Finegold at Baylor College of Medicine, showed that the Math1 gene -- which codes for a gene-activating protein called a transcription factor -- is necessary for the differentiation of three kinds of intestinal cells from stem cells. The team published its findings in the December 7, 2001, issue of the journal Science.

Previous work by Zoghbi and her colleagues revealed Math1s role in governing differentiation of neuronal cells, including sensory cells in the inner ear. In the course of those earlier studies, we detected Math1 expression in the intestine, said Zoghbi. Its function there was unknown. However, we knew that the gut has a nervous system of its own, so we thought Math1 might be important for components of that system, she said.

To pinpoint the genes activity, the researchers genetically engineered mice in which the coding region of the Math1 gene was replaced by an enzyme that would stain the cells expressing the gene in developing mouse embryos. They first examined mice with one copy of the functional Math1 gene, along with the stain-producing gene, to determine which cells expressed Math1.

To our total surprise, we could not detect expression of the gene in the nervous system of the gut, but instead found it in the intestinal epithelium, said Zoghbi. These studies revealed that three kinds of secretory cells expressed Math1. These were goblet cells that secrete mucous important for food movement; enteroendocrine cells that secrete regulatory peptides, and Paneth cells that secrete microbe-fighting pept

Contact: Jim Keeley
Howard Hughes Medical Institute

Page: 1 2 3

Related biology news :

1. Study suggests cell-cycle triggers might be cancer drug targets
2. Sick Kids researchers look at viral triggers for multiple sclerosis in children
3. Retroviral protein triggers proliferation of immune cells
4. A new mechanism that triggers autoimmune disease
5. Researchers find enzyme that triggers hardening of the arteries
6. Fatty food triggers taste buds, new research finds
7. Aspirin targets key cell that triggers organ rejection and other immune responses, report University of Pittsburgh researchers in journal article
8. Genome project finds the triggers for E. coli illness
9. How a hormonal henchman triggers death
10. El Niño triggers tropical forest reproduction
11. Single switch triggers two immune system genes

Post Your Comments:

(Date:5/16/2016)...   EyeLock LLC , a market leader of ... an IoT Center of Excellence in Austin, ... of embedded iris biometric applications. EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
(Date:4/28/2016)... 28, 2016 First quarter 2016:   ... compared with the first quarter of 2015 The gross ... M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... is unchanged, SEK 7,000-8,500 M. The operating margin for ...
(Date:4/15/2016)... , April 15, 2016 ... "Global Gait Biometrics Market 2016-2020,"  report to their ... ) , ,The global gait biometrics market ... 13.98% during the period 2016-2020. Gait ... which can be used to compute factors that ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... ... pleased to announce the launch of their brand, UP4™ Probiotics, into Target stores ... 35 years, is proud to add Target to its list of well-respected retailers. ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute approval ... of microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory ...
(Date:6/23/2016)... OTTAWA, ON (PRWEB) , ... June 23, 2016 , ... ... former DNA Technical Leader at the Arkansas State Crime Laboratory, has joined STACS DNA ... joining the STACS DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. ...
(Date:6/23/2016)... June 23, 2016 On Wednesday, June ... 4,833.32, down 0.22%; the Dow Jones Industrial Average edged 0.27% ... at 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage on the ... Nektar Therapeutics (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. ... BIND ). Learn more about these stocks by ...
Breaking Biology Technology:
Cached News: