HOME >> BIOLOGY >> NEWS
Gene triggers stem cell differentiation in the intestine

A gene that governs development of neuronal cells has now been shown to be involved in regulating differentiation of stem cells into secretory cells in the intestine.

The research team, which included Howard Hughes Medical Institute investigator Huda Zoghbi, Qi Yang, Nessan Bermingham and Milton Finegold at Baylor College of Medicine, showed that the Math1 gene -- which codes for a gene-activating protein called a transcription factor -- is necessary for the differentiation of three kinds of intestinal cells from stem cells. The team published its findings in the December 7, 2001, issue of the journal Science.

Previous work by Zoghbi and her colleagues revealed Math1s role in governing differentiation of neuronal cells, including sensory cells in the inner ear. In the course of those earlier studies, we detected Math1 expression in the intestine, said Zoghbi. Its function there was unknown. However, we knew that the gut has a nervous system of its own, so we thought Math1 might be important for components of that system, she said.

To pinpoint the genes activity, the researchers genetically engineered mice in which the coding region of the Math1 gene was replaced by an enzyme that would stain the cells expressing the gene in developing mouse embryos. They first examined mice with one copy of the functional Math1 gene, along with the stain-producing gene, to determine which cells expressed Math1.

To our total surprise, we could not detect expression of the gene in the nervous system of the gut, but instead found it in the intestinal epithelium, said Zoghbi. These studies revealed that three kinds of secretory cells expressed Math1. These were goblet cells that secrete mucous important for food movement; enteroendocrine cells that secrete regulatory peptides, and Paneth cells that secrete microbe-fighting pept
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
6-Dec-2001


Page: 1 2 3

Related biology news :

1. Study suggests cell-cycle triggers might be cancer drug targets
2. Sick Kids researchers look at viral triggers for multiple sclerosis in children
3. Retroviral protein triggers proliferation of immune cells
4. A new mechanism that triggers autoimmune disease
5. Researchers find enzyme that triggers hardening of the arteries
6. Fatty food triggers taste buds, new research finds
7. Aspirin targets key cell that triggers organ rejection and other immune responses, report University of Pittsburgh researchers in journal article
8. Genome project finds the triggers for E. coli illness
9. How a hormonal henchman triggers death
10. El Niño triggers tropical forest reproduction
11. Single switch triggers two immune system genes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed ... received the prestigious international IAIR Award for the most innovative high security ... ... Maldives Immigration Controller General, ... picture on the right) have received the IAIR award for the "Most ...
(Date:3/23/2017)... 2017 The report "Gesture Recognition and Touchless Sensing Market ... - Global Forecast to 2022", published by MarketsandMarkets, the market is expected to ... between 2017 and 2022. Continue Reading ... ... ...
(Date:3/22/2017)... Lithuania , March 21, 2017   ... and object recognition technologies, today announced the release ... kit (SDK), which provides improved facial recognition using ... cameras on a single computer. The new version ... to improve accuracy, and it utilizes a Graphing ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... , ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. ... The event entitled “Stem Cells and Their Regenerative Powers,” was held on August ... MPVM was joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic ...
(Date:10/10/2017)... BARBARA, CALIFORNIA (PRWEB) , ... October 10, 2017 ... ... management, technological innovation and business process optimization firm for the life sciences and ... BoxWorks conference in San Francisco. , The presentation, “Automating GxP Validation ...
(Date:10/9/2017)... ... , ... The award-winning American Farmer television series will feature 3 Bar Biologics ... at 8:30aET on RFD-TV. , With global population estimates nearing ten billion people ... to feed a growing nation. At the same time, many of our valuable resources ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses ... EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The ...
Breaking Biology Technology:
Cached News: