HOME >> BIOLOGY >> NEWS
Gene triggers stem cell differentiation in the intestine

A gene that governs development of neuronal cells has now been shown to be involved in regulating differentiation of stem cells into secretory cells in the intestine.

The research team, which included Howard Hughes Medical Institute investigator Huda Zoghbi, Qi Yang, Nessan Bermingham and Milton Finegold at Baylor College of Medicine, showed that the Math1 gene -- which codes for a gene-activating protein called a transcription factor -- is necessary for the differentiation of three kinds of intestinal cells from stem cells. The team published its findings in the December 7, 2001, issue of the journal Science.

Previous work by Zoghbi and her colleagues revealed Math1s role in governing differentiation of neuronal cells, including sensory cells in the inner ear. In the course of those earlier studies, we detected Math1 expression in the intestine, said Zoghbi. Its function there was unknown. However, we knew that the gut has a nervous system of its own, so we thought Math1 might be important for components of that system, she said.

To pinpoint the genes activity, the researchers genetically engineered mice in which the coding region of the Math1 gene was replaced by an enzyme that would stain the cells expressing the gene in developing mouse embryos. They first examined mice with one copy of the functional Math1 gene, along with the stain-producing gene, to determine which cells expressed Math1.

To our total surprise, we could not detect expression of the gene in the nervous system of the gut, but instead found it in the intestinal epithelium, said Zoghbi. These studies revealed that three kinds of secretory cells expressed Math1. These were goblet cells that secrete mucous important for food movement; enteroendocrine cells that secrete regulatory peptides, and Paneth cells that secrete microbe-fighting pept
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
6-Dec-2001


Page: 1 2 3

Related biology news :

1. Study suggests cell-cycle triggers might be cancer drug targets
2. Sick Kids researchers look at viral triggers for multiple sclerosis in children
3. Retroviral protein triggers proliferation of immune cells
4. A new mechanism that triggers autoimmune disease
5. Researchers find enzyme that triggers hardening of the arteries
6. Fatty food triggers taste buds, new research finds
7. Aspirin targets key cell that triggers organ rejection and other immune responses, report University of Pittsburgh researchers in journal article
8. Genome project finds the triggers for E. coli illness
9. How a hormonal henchman triggers death
10. El Niño triggers tropical forest reproduction
11. Single switch triggers two immune system genes

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene triggers stem cell differentiation the intestine

(Date:7/7/2015)... 2015 Research and ... of the "Capacitive Fingerprint Sensors Patent Landscape" ... this date, fingerprint sensing technology is the most ... are well developed. This patent landscape focuses on ... The domain of capacitive fingerprint sensors is closely ...
(Date:7/2/2015)... , June 25, 2015 ... of the "Next Generation Biometrics Market by Application, ... report to their offering. The next ... by 2020, at a CAGR of 17.9% between 2015 ... leading application for the market. Safran SA ...
(Date:6/29/2015)... Research and Markets( http://www.researchandmarkets.com/research/zj7h4f/latin_america ) has ... Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... Biomedical Sensors market is estimated at $0.65 billion by ... 2014-2020 The near future will bring Biomedical ... each individual. These sensors can be set to trigger ...
Breaking Biology News(10 mins):Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3Latin America Biomedical Sensors Market Report 2015-2020 2
(Date:7/29/2015)... BANGALORE , July 30, 2015 ... Cell Market - Growth, Trends & Forecasts (2015-2020), , published ... worth US$ 30.25 billion by the end of 2020, with ... globally accounting for more than 40% of the global market ... grow at a CAGR of 13.7% during the period of ...
(Date:7/29/2015)... 29, 2015  HealthSouth Corporation (NYSE: ... of post-acute healthcare services, offering both facility-based and ... operations for the second quarter ended June 30, 2015. ... by strong volume growth in both segments and ... Jay Grinney, President and Chief Executive Officer of ...
(Date:7/29/2015)... ... July 29, 2015 , ... Brady (NYSE:BRC), a ... Label Guide . To align chemical container labeling with OSHA’s updated Hazard Communication ... label components, an example of an accurate label, and pictogram uses and meanings. ...
(Date:7/29/2015)... July 29, 2015  Indivior PLC (LON: INDV) today ... nasal spray was accepted and received Priority Review by ... treatment of opioid overdose. This naloxone nasal spray comes ... for optimal absorption into the nasal mucosa. 1 ... so individuals may be better equipped to help an ...
Breaking Biology Technology:Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 3HealthSouth Reports Results for Second Quarter 2015 2HealthSouth Reports Results for Second Quarter 2015 3HealthSouth Reports Results for Second Quarter 2015 4HealthSouth Reports Results for Second Quarter 2015 5HealthSouth Reports Results for Second Quarter 2015 6HealthSouth Reports Results for Second Quarter 2015 7HealthSouth Reports Results for Second Quarter 2015 8HealthSouth Reports Results for Second Quarter 2015 9HealthSouth Reports Results for Second Quarter 2015 10HealthSouth Reports Results for Second Quarter 2015 11HealthSouth Reports Results for Second Quarter 2015 12HealthSouth Reports Results for Second Quarter 2015 13HealthSouth Reports Results for Second Quarter 2015 14HealthSouth Reports Results for Second Quarter 2015 15HealthSouth Reports Results for Second Quarter 2015 16HealthSouth Reports Results for Second Quarter 2015 17HealthSouth Reports Results for Second Quarter 2015 18HealthSouth Reports Results for Second Quarter 2015 19HealthSouth Reports Results for Second Quarter 2015 20HealthSouth Reports Results for Second Quarter 2015 21HealthSouth Reports Results for Second Quarter 2015 22HealthSouth Reports Results for Second Quarter 2015 23HealthSouth Reports Results for Second Quarter 2015 24HealthSouth Reports Results for Second Quarter 2015 25HealthSouth Reports Results for Second Quarter 2015 26HealthSouth Reports Results for Second Quarter 2015 27HealthSouth Reports Results for Second Quarter 2015 28HealthSouth Reports Results for Second Quarter 2015 29HealthSouth Reports Results for Second Quarter 2015 30HealthSouth Reports Results for Second Quarter 2015 31HealthSouth Reports Results for Second Quarter 2015 32HealthSouth Reports Results for Second Quarter 2015 33HealthSouth Reports Results for Second Quarter 2015 34
Cached News: