Gene variant increases risk of cardiac arrhythmia for African-Americans

A variant form of a gene found in the heart muscle of some African-Americans increases the chances of developing a potential deadly heart condition called cardiac arrhythmia, say researchers from the Howard Hughes Medical Institute at Children's Hospital in Boston.

The finding could benefit African-Americans by making it possible to detect who is at increased risk for developing arrhythmia and allowing those affected to take preventive measures. The study is one of the first in which researchers have been able to discern how genetics influences arrhythmia risk across a range of populations of people who originated from different geographic regions.

In an article published in the August 23, 2002, issue of the journal Science, the research team led by HHMI investigator Mark T. Keating reported that 13.2 percent of African-Americans in the study carried an altered form of the gene SCN5A. This gene codes for a protein called a sodium channel, a molecular pore that initiates heartbeats by allowing sodium to flow across the membrane of the cardiac muscle cell.

The variant form of the gene creates sodium channels in heart muscle cells that remain open longer than normal sodium channels, prolonging contraction of the heart and contributing to arrhythmia. Keating authored the paper with colleagues at Harvard Medical School, the University of Utah, Columbia University and St. George's Hospital Medical School in London.

Keating emphasized that although arrhythmias are serious disorders, the effect of the gene variant is subtle. "People who have this gene variant are not likely to have an arrhythmia," he said. "All of us harbor gene variants that we may not know about. Fortunately, our hearts are remarkably well buffered against such problems, and arrhythmias are rare. What's often required for a dangerous arrhythmia is that several things go wrong at the same time

Contact: Jim Keeley
Howard Hughes Medical Institute

Page: 1 2 3 4

Related biology news :

1. Schizophrenia gene variant linked to risk traits
2. Gene variants may increase susceptibility to type 2 diabetes
3. Common gene variant increases risk of atherosclerosis
4. Gene variant discovery could save blood in surgery
5. Invariant properties in coevolutionary networks of plant-animal interactions
6. UCSD bioengineers develop first computer model that predicts disease variant based on genetic defect
7. Genetic variant protects people against malaria
8. Scientists identify gene variant associated with arrhythmia in African Americans
9. Genetic variants put some patients at risk for particular drug reactions
10. Genetic variants linked to higher risk of high blood pressure in African Americans
11. HIV variant in U.S. and Europe found rare in Africa AIDS cases

Post Your Comments:

(Date:8/26/2020)... ... August 25, 2020 , ... ... solutions for drugs, biologics, cell and gene therapies, and consumer health products, today ... PEGS Boston Virtual Conference & Expo, taking place between Aug. 31 – September ...
(Date:8/21/2020)... ... August 19, 2020 , ... “How can we help?”, asks ... Salivary Bioscience for more than twenty years. Together with Douglas Granger, Ph.D., founder ... Bioscience: Foundations of Interdisciplinary Saliva Research and Applications ," and Steven Granger, Ph.D., ...
(Date:8/12/2020)... , ... August 12, 2020 , ... ... monitoring systems that are ideal for public health agencies of all sizes. With ... diseases and helping at-risk individuals find appropriate health care, Mosio helps public health ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... BALTIMORE (PRWEB) , ... July ... ... Baltimore biotechnology company, announced today that Massachusetts Institute of Technology (MIT) has ... This broader license allows PathSensors to move into the point-of-care diagnostic market, ...
(Date:7/10/2020)... , ... July 09, 2020 , ... ... cell therapy, today announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as ... oversee the clinical development of Sentien’s lead product, SBI-101. Dr. Nissenson serves ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT World has announced the ... Squibb, the University of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia ... program, highlighting outstanding examples of how technology innovations and strategic initiatives can be ...
(Date:7/1/2020)... ... June 29, 2020 , ... The Interlocal Purchasing ... to its membership, recently named BioFit Engineered Products an Awarded Vendor. ... purchase ergonomic seating, cafeteria tables, book trucks and carts at discounted pricing without ...
Breaking Biology Technology:
Cached News: