HOME >> BIOLOGY >> NEWS
Gene variation raises risk of bipolar disorder and schizophrenia

A research team based at the University of Chicago has traced increased susceptibility to bipolar disorder to two overlapping genes found on the long arm of chromosome 13. The study, published in the May 2003 issue of the American Journal of Human Genetics, is the first to implicate this gene complex, and the second to tie any gene, to the development of bipolar disorder, which affects 2 million American adults.

A previous study found that the same gene complex increases risk for schizophrenia. The current finding adds credence to the emerging notion that the same genes may be contribute to both disorders.

"The discovery of susceptibility genes for psychiatric disorders has been one of the most intractable problems in human genetics," said Elliot Gershon, M.D., professor and chairman of psychiatry at the University of Chicago and a co-author of the study. "In the past two years, we seem to have reached a watershed for psychiatric gene discovery, with the identification of genes that increase risk of bipolar disorder and schizophrenia. After years of false starts and unfulfilled promises, we have begun to make real progress."

Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes profound shifts in a person's mood, with spurts of high energy and elation alternating with longer periods of fatigue and deep sadness. It affects about one percent of adults, usually beginning in late adolescence.

The disorder is caused by multiple genes, each contributing a small part. The bipolar gene on chromosome 13 has a "weak effect," said Gershon, increasing susceptibility to the disease by about 25 percent.

The implicated genes, known as G30 and G72, were discovered through positional cloning, an approach that relies on small differences between family members who have a disease and those who do not to track down the genes that increase risk. With this approach the researchers do not have to know the
'"/>

Contact: John Easton
jeaston@uchospitals.edu
773-702-6241
University of Chicago Medical Center
24-Apr-2003


Page: 1 2

Related biology news :

1. The impact of genetic variations on the treatment of early rheumatoid arthritis
2. Improving crops without genetic modification natural variation holds the key
3. DNA variations surprise researchers
4. Researchers uncover surprising degree of large-scale variation in the human genome
5. Natural selection at work in genetic variation to taste
6. Genetic basis for individual variations in the response to stress
7. Surprises found in gene variation associated with schizophrenia
8. Announcement of the chicken genome sequence and genome variation maps
9. Genetic aberration helps explain variation in cystic fibrosis
10. Stanford research finds gene variations that alter antidepressant side effects
11. U of MN researchers find genetic variations may predict treatment responses for myeloma

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2019)... CONSHOHOCKEN, Pa. (PRWEB) , ... May 21, 2019 , ... ... trial randomization and drug supply chain management, has been named one of Inc. Magazine’s ... , The full list , now featured on Inc.com and hitting the newsstands ...
(Date:5/21/2019)... ... May 21, 2019 , ... At their May 16 ... Tissue Engineered Medical Products (TEMPs) of the American Society for Testing and Materials ... Gaining this approval was the next step in the company’s plan to establish ...
(Date:5/14/2019)... (PRWEB) , ... May 13, 2019 , ... ... Tuesday, June 4th, at a very special Pre-EWMA 2019 event at Gothenburg’s Universeum ... the latest Trends, Opportunities and Innovations in Advanced Wound Care. , SmartTRAK’s Advanced ...
Breaking Biology News(10 mins):
(Date:4/16/2019)... ... April 16, 2019 , ... ... their project partner, the U.S. Army Center for Environmental Health Research (USACEHR), with ... Combined In-Licensing/Out-Licensing.” , Blue Sources, a veteran-owned company located at the Frederick Innovative ...
(Date:4/15/2019)... ... 15, 2019 , ... Sirrus, Inc., a developer of novel ... expansion to increase production of methylene malonate monomers and oligomers. , The expanded ... full-scale production facility, which is scheduled to break ground in 2019. “The expanded ...
(Date:4/10/2019)... ... April 10, 2019 , ... ... have locked into multiple agreements to help companies advance their innovations to ... industry, ranging from synthetic biology companies that are gene editing therapeutic cells ...
(Date:4/9/2019)... , ... April 09, 2019 , ... ... focused on increasing the capacity of life sciences organizations to accelerate innovation and ... Assurance platform in the past 12 months. , USDM’s Cloud Assurance ...
Breaking Biology Technology:
Cached News: