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Gene vital to radiation resistance in bacteria

NEW ORLEANS January 31, 2003 -- Researchers from Louisiana State University have identified a gene in the radiation-resistant bacterium Deinococcus radiodurans that they believe is vital to the organism's ability to withstand high levels of radiation. They report their findings today at the 3rd ASM/TIGR Conference on Microbial Genomes.

"When this gene (irrE) is not functional you have a very sensitive organism," says Ashlee Earl, a lead researcher on the study. "At a dose of radiation that would not normally kill D. radiodurans, there is less than .001 percent survival without irrE."

With a name that literally means "strange berry that can withstand radiation," D. radiodurans is the world's most radiation resistant organism, able to survive up to 1.5 million rads, over 1000 times more radiation than practically any other organism. For reference, 1000 rads is enough to kill the average human.

For decades scientists have been trying to figure out what makes it so hard to kill. Understanding how this bacterium survives such extreme conditions could help researchers with everything from cleaning up nuclear waste sites to preventing cancer.

To better define the mechanisms used by the bacterium to resist radiation, Earl and her team, which included researchers from The Institute for Genomic Research (TIGR), studied a mutant strain of D. radiodurans that could not survive high radiation levels. This strain carried mutations on two genes, one of which was irrE. When the irrE gene was restored, the bacterium was once again resistant to radiation, a finding that suggested the gene was responsible, at least in some part, for resistance.

Further study of irrE suggested that the gene is not directly responsible for DNA repair following radiation exposure but instead it controls other genes that are known in other organisms to be associated with DNA repair. It's role is also not specific to radiation. The gene is responsible in some part for D.
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Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
31-Jan-2003


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