HOME >> BIOLOGY >> NEWS
Gene with key role in replicating pox viruses also halts inflammation

CHAMPAIGN, Ill. -- Scientists at the University of Illinois at Urbana-Champaign studying vaccinia virus, a close relative of smallpox, have determined that a gene necessary for virus replication also has a key role in turning off inflammation, a crucial anti-viral immune response of host cells.

The discovery, reported this month in the Journal of Virology, potentially broadens the knowledge base of how all poxviruses cause disease and how they may be outwitted by improvements in vaccines against them, said Joanna L. Shisler, a professor of microbiology in the College of Medicine at Urbana-Champaign.

"If we can find out how the virus evades immune responses and learn more about the signals the virus sees as necessary for replicating within the host cell, then we can figure out how to inhibit them and halt the viral replication," she said.

Post 9-11 fears of bioterrorism by means of the deliberate introduction of smallpox have spawned renewed interest in new, safer vaccines against the deadly disease, which was eradicated as a naturally occurring danger in 1977. Some U.S. medical workers and military personnel have received vaccinations made of the live vaccinia virus, but while this tamer relative of smallpox normally doesn't cause disease, complications, including death, are possible especially among immune-compromised individuals.

The vaccinia virus genome is 97 percent genetically identical to the smallpox genome, making it an ideal model virus to use in the laboratory to understand how smallpox and other dangerous poxviruses function, Shisler said.

In their research, Shisler and Xiao-Lu Jin, a research specialist in microbiology, found that a 5.2 kb segment of vaccinia virus DNA containing six genes was responsible for inhibiting a key cellular transcription factor called NF kappa B (NF-kB).

NF-kB serves to turn on other host cell genes involved in anti-viral immune responses and inflammation.

The researchers
'"/>

Contact: Jim Barlow, Life Sciences Editor
jebarlow@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
6-Apr-2004


Page: 1 2

Related biology news :

1. Cannabis may help combat cancer-causing herpes viruses
2. Scientists find nanowires capable of detecting individual viruses
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. Defensive action by influenza viruses demonstrated by Hebrew university researcher
5. Bright idea could doom cancer and viruses, say Purdue scientists
6. Measuring artificial viruses to improve disease detection
7. Study suggests double punch could more efficiently kill viruses
8. Mite transmits viruses damaging to wheat
9. A new way to kill cancer: SLU research shows viruses can destroy lung, colon tumors
10. Genetic trick adapted from viruses makes gene therapy vectors more versatile
11. Study: Mimicking viruses may provide new way to defeat them

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... (PRWEB) , ... August 14, 2019 , ... ... broadcast 4Q/2019, will explore how developments in microbiome therapeutics are helping to promote ... listings for more information. , Advancements will educate about the DECODE.DESIGN.CURE™ technology platform, ...
(Date:8/14/2019)... ... 2019 , ... Join Anguraj Sadanandam, PhD, Team Leader, Systems ... (ICR) in a live webinar on Wednesday, September 4, 2019 at ... diagnostic development including machine learning approaches in different gastrointestinal cancers and their translational ...
(Date:8/6/2019)... ... August 05, 2019 , ... Keck Graduate Institute (KGI) President Sheldon Schuster has ... Sciences (SPHS). , “Dean Zdanowicz is highly regarded as an innovative leader who prioritizes ... is a great choice to build on the success of the KGI School of ...
Breaking Biology News(10 mins):
(Date:7/11/2019)... ... 11, 2019 , ... At the most recent stem cell training course ... Veterans under the R3 Heroes Program. The Veterans included individuals and families from all ... anyone to nominate a military Veteran, teacher or first responder to receive a regenerative ...
(Date:6/18/2019)... ... June 17, 2019 , ... IVERIC ... into an agreement for production and manufacturing of GMP-grade adeno-associated virus (AAV) vector ... autosomal dominant retinitis pigmentosa (RHO-adRP) and IC-200 for the treatment of BEST1 related ...
(Date:6/11/2019)... ... June 10, 2019 , ... ... will add 80 of its scientific journals to DeepDyve’s rental service for peer-reviewed ... DeepDyve’s continually expanding library of more than 20 million articles, sourced from more ...
(Date:5/31/2019)... ... 2019 , ... For many years, the primary forms of cancer treatment have ... Advances in immuno-oncology have led to the advent of Chimeric Antigen Receptor T (CAR ... receptors known as “CARs”. The CAR enables the final product to produce chemicals in ...
Breaking Biology Technology:
Cached News: