Genes Found That Label Cell Proteins For Disposal

CHAPEL HILL, N.C. - Scientists at the University of North Carolina at Chapel Hill have discovered three genes crucial to the survival of cells. The genes select cellular proteins for the disposal and eventual recycling of their components.

Because some of these proteins have been implicated in cancer and other human illnesses, failure or disruption of this cellular mechanism may promote the disease process, according to Dr. Yue Xiong, assistant professor of biochemistry and biophysics at the UNC-CH School of Medicine.

"Balance is the key word. How the cell cycle of growth and division maintains balance is what we're studying," Xiong says. "It may be that human diseases are somehow linked to a degradation breakdown, one that leads to imbalance of proteins."

Xiong, a member of the UNC Lineberger Comprehensive Cancer Center, points to the known tumor suppressor p53 as an example. Normally, p53 is present within cells in relatively minute amounts. "If it's degraded too much, the protein never accumulates and you get tumor development. If this protein accumulates too much, the cell won't grow," he explains.

Another example is the cancer-related myc (pronounced MIK) oncogene and the protein it transcribes. "If this protein accumulates too much, you get cancer because this is the gene driving cells to grow, grow and grow."

A third example is proto-oncogene, cyclin D, which was discovered several years ago by Xiong and his colleagues at the Cold Spring Harbor Laboratory in New York Cyclin D, together with its partner, CDK4, controls a critical cellular decision: to divide and grow or to arrest. Cyclin D has been found in a high percentage of human head and neck cancers and breast cancers. "When over-expressed in mouse mammary glands, cyclin D causes breast cancer," Xiong says.

The UNC-CH discovery is the first to clarify a key component of the cellular degradation process or pathway - specifically, the mechanism by which

Contact: Lynn Wooten
University of North Carolina School of Medicine

Page: 1 2 3

Related biology news :

1. Genes expose secrets of sex on the side
2. Genes can influence both alcohol consumption and dependence
3. Genes may be central to cocaine addiction
4. Genes appear to play a role in development of chronic obstructive pulmonary disease
5. Genes make the marsh
6. Genes predict response of adult leukemia patients to chemotherapy
7. Genes influence memory in families with Alzheimers disease
8. Genes control severity of heart failure, study finds
9. Genes that regulate hearing link humans and fruit flies in new way
10. Genes discovered that regulate blood stem cell development
11. Genes that paint fly derrieres hint at convergence

Post Your Comments:

(Date:6/4/2019)... ... 2019 , ... Harper was three years old when her owners took her ... caused painful osteoarthritis in the joints. She was referred to a veterinary specialist ... surgical specialist, Dr. Christopher Eich of Southern California Veterinary Specialty Hospital , examined ...
(Date:6/4/2019)... ... June 04, 2019 , ... Lajollacooks4u is delighted to announce it has been ... hospitality excellence, is given only to businesses that have achieved consistently outstanding traveler reviews ... , To qualify for the Certificate of Excellence –- an award that ...
(Date:6/1/2019)... ... 31, 2019 , ... The University of Vermont Health Network ... $6M Series B Financing Round. , “With the commitment from the UVM ... financial and business resources to bear as we advance our biopharmaceutical products to ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... N.C. (PRWEB) , ... May 30, 2019 , ... ... is the first to demonstrate an efficient delivery system for the sustained release ... injuries. The platelet-rich plasma-based gel system was able to deliver CM into the ...
(Date:5/15/2019)... ... May 16, 2019 , ... Emulsifiers are ... food and beverage products rely on these ingredients to create stable quality food ... declarations. This paradigm shift triggers food formulators to seek out alternatives for starches, ...
(Date:5/7/2019)... ... May 06, 2019 , ... "The new ... number of repositories being asked to store cellular products being used in ... contributors who are world leaders, who have shared their expertise in building and ...
(Date:5/2/2019)... ... April 30, 2019 , ... The centuries old practice of brewing beer ... local craft breweries, and even home brewing clubs scattered across the nation. , ... that when mastered can produce a superb product. Students at South Dakota School ...
Breaking Biology Technology:
Cached News: