HOME >> BIOLOGY >> NEWS
Genes Found That Label Cell Proteins For Disposal

proteins within cells are selected and "marked" for removal and destruction after they have done their job.

In their report published in the April 23 issue of the journal Molecular Cell, Xiong and his co-authors, Tomohiko Ohta, Jennifer J. Michel and Arndt J. Schottelius, describe having identified the proteins ROC1, ROC2 and APC11. These closely related proteins, particularly ROC1, combine with other proteins called cullins to form an enzyme, a ubiquitin ligase. This enzyme then accelerates a biochemical reaction in which a molecule called ubiquitin is attached to cellular proteins. Thus "ubiquitinized," the protein is marked for disposal and degradation. After degradation, the cell then recycles the protein's amino acids to build other proteins.

"Once a protein is attached to ubiquitin, another cellular mechanism recognizes that it's ubiquitinated and takes it to a specific place called the proteasome," Xiong points out. "It's like garbage collection. Unless you put your garbage out in the street, it won't get picked up and taken to the dump." In cells, the dumpsite is the proteasome's protein degradation machinery.

"Abnormal level of proteins, too high in the case of oncoproteins such as myc or cyclin D or too low in the case of tumor suppressor proteins such as p53, have one common consequence. They drive cells to continue proliferating when normal cells would not," Xiong says. "How these proteins in tumor cells escape from normal ubiquitin-mediated degradation is currently unknown."

Xiong and scientists elsewhere are working to solve this problem by identifying essential components involved in the normal control of protein degradation.

In their journal report, the UNC-CH researchers also note that the newly identified proteins can combine with five different cullins. "That means there are many binary ubiquitin ligases," Xiong says. "And it raises the possibility that degradation of different proteins may each require a differ
'"/>

Contact: Lynn Wooten
LWooten@unch.unc.edu
919-966-6046
University of North Carolina School of Medicine
26-Apr-1999


Page: 1 2 3

Related biology news :

1. Genes expose secrets of sex on the side
2. Genes can influence both alcohol consumption and dependence
3. Genes may be central to cocaine addiction
4. Genes appear to play a role in development of chronic obstructive pulmonary disease
5. Genes make the marsh
6. Genes predict response of adult leukemia patients to chemotherapy
7. Genes influence memory in families with Alzheimers disease
8. Genes control severity of heart failure, study finds
9. Genes that regulate hearing link humans and fruit flies in new way
10. Genes discovered that regulate blood stem cell development
11. Genes that paint fly derrieres hint at convergence

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Genes Found That Label Cell Proteins For Disposal

(Date:11/10/2014)... appearing on U.S. store shelves in early 2010, and ... The small packets can be tossed into a washing ... or powder. The convenience, though, has come with risks ... at Nationwide Children,s Hospital found that from 2012 through ... children younger than 6 years of age swallowing, inhaling, ...
(Date:11/6/2014)... because of metastasis, yet progress in preventing and ... "It,s been particularly challenging to design drugs that ... in systems biology at Harvard Medical School. ... they,ve already metastasized." , Gujral and colleagues have ... researchers better understand how metastasis begins. Their findings ...
(Date:11/5/2014)... de Janeiro, Brazil -Individuals show great diversity in their ... males and females greatly differ in their perceptual evaluation ... of smell tests. , Sex differences in ... behaviors and may be connected to one,s perception of ... emotions. Thus, women,s olfactory superiority has been suggested to ...
Breaking Biology News(10 mins):Study finds laundry detergent pods, serious poisoning risk for children 2Migration negation 2Migration negation 3The female nose always knows: Do women have more olfactory neurons? 2
(Date:11/18/2014)... LA (PRWEB) November 17, 2014 ... build-to-order, open architecture blade-based and rackmount computing infrastructure, ... Tesla® K80 dual-GPU accelerator throughout its GPU-enabled blade ... pair of the company’s latest proprietary 80-lane Gen3 ... eight discrete NVIDIA Tesla K80 dual-GPU accelerator cards ...
(Date:11/18/2014)... Athena Signature Series: Turning Cancer ‘Off’ – featuring ... professor in the Regulatory Biology Laboratory at the Salk Institute, ... to an “off switch” for drug resistance in cancer. , ... research is making a global impact in the fight against ... host Cheryl K. Goodman, CEO of Social Global Mobile LLC, ...
(Date:11/18/2014)... 18, 2014 American Process Inc. ... formed a partnership with researchers at Georgia Institute ... Technology, and the USDA’s Forest Products Laboratory to ... nanocellulose. Nanocellulose is a rapidly emerging high performance ... project is to replace heavy steel structures within ...
(Date:11/18/2014)... 2014 2014 Deep Research ... professional and in-depth report on Polytetrahydrofuran (PTMEG) ... including its definition, characterization, application, and industry ... exploration covers the worldwide business investigation, including ... covering macroeconomic environment & financial circumstance examination. ...
Breaking Biology Technology:Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 2Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 3American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 2American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 3PTMEG Market: 2019 Global Polytetrahydrofuran Industry Development Trends & Analysis Now at DeepResearchReports.com 2PTMEG Market: 2019 Global Polytetrahydrofuran Industry Development Trends & Analysis Now at DeepResearchReports.com 3
Cached News: