HOME >> BIOLOGY >> NEWS
Genes Found That Label Cell Proteins For Disposal

proteins within cells are selected and "marked" for removal and destruction after they have done their job.

In their report published in the April 23 issue of the journal Molecular Cell, Xiong and his co-authors, Tomohiko Ohta, Jennifer J. Michel and Arndt J. Schottelius, describe having identified the proteins ROC1, ROC2 and APC11. These closely related proteins, particularly ROC1, combine with other proteins called cullins to form an enzyme, a ubiquitin ligase. This enzyme then accelerates a biochemical reaction in which a molecule called ubiquitin is attached to cellular proteins. Thus "ubiquitinized," the protein is marked for disposal and degradation. After degradation, the cell then recycles the protein's amino acids to build other proteins.

"Once a protein is attached to ubiquitin, another cellular mechanism recognizes that it's ubiquitinated and takes it to a specific place called the proteasome," Xiong points out. "It's like garbage collection. Unless you put your garbage out in the street, it won't get picked up and taken to the dump." In cells, the dumpsite is the proteasome's protein degradation machinery.

"Abnormal level of proteins, too high in the case of oncoproteins such as myc or cyclin D or too low in the case of tumor suppressor proteins such as p53, have one common consequence. They drive cells to continue proliferating when normal cells would not," Xiong says. "How these proteins in tumor cells escape from normal ubiquitin-mediated degradation is currently unknown."

Xiong and scientists elsewhere are working to solve this problem by identifying essential components involved in the normal control of protein degradation.

In their journal report, the UNC-CH researchers also note that the newly identified proteins can combine with five different cullins. "That means there are many binary ubiquitin ligases," Xiong says. "And it raises the possibility that degradation of different proteins may each require a differ
'"/>

Contact: Lynn Wooten
LWooten@unch.unc.edu
919-966-6046
University of North Carolina School of Medicine
26-Apr-1999


Page: 1 2 3

Related biology news :

1. Genes expose secrets of sex on the side
2. Genes can influence both alcohol consumption and dependence
3. Genes may be central to cocaine addiction
4. Genes appear to play a role in development of chronic obstructive pulmonary disease
5. Genes make the marsh
6. Genes predict response of adult leukemia patients to chemotherapy
7. Genes influence memory in families with Alzheimers disease
8. Genes control severity of heart failure, study finds
9. Genes that regulate hearing link humans and fruit flies in new way
10. Genes discovered that regulate blood stem cell development
11. Genes that paint fly derrieres hint at convergence

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Genes Found That Label Cell Proteins For Disposal

(Date:7/8/2015)... N.J. and NEW YORK , July 8, ... Guidepoint today announced BD & Guidepoint Mentor, ... with free access to Guidepoint,s expert network services. ... are developing cutting-edge technologies to improve healthcare delivery and ... research manager, each start-up entrepreneur will be able to ...
(Date:7/7/2015)... Calif. , July 7, 2015  Based ... market, Frost & Sullivan recognizes Credence ID, LLC ... Entrepreneurial Company of the Year Award. Credence ... to aid in its mission of offering enrollment ... populations globally. As Credence ID was formed by ...
(Date:7/2/2015)... Fingerprint Cards has received an order ... from the distributor World Peace Industrial Group (WPI), part of ... Asia . Deliveries are planned to take place ... by smartphone manufacturers in Asia . The ... revenue guidance of approximately 2,200 MSEK for 2015. ...
Breaking Biology News(10 mins):BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
(Date:7/29/2015)... PARIS , July 30, 2015 ... de la santé, publie ses résultats pour le ... Brandicourt commente les résultats. Visionner ... http://www.eurobusinessmedia.com/ceo-direct/sanofi/sanofi-h1-2015-results-interview-with-ceo-olivier-brandicourt?utm_source=ceo-direct&utm_medium=wire Au sommaire ... - Moteurs de croissance ...
(Date:7/29/2015)... , July 29, 2015 US-Australian drug discovery ... today confirmed it is committed to progressing its ground-breaking ... as practicable and to ensure the Company delivers the ... Officer, Iain Ross , said the Company currently ... lead pre-clinical programs, discovery programs and academic partnerships and ...
(Date:7/29/2015)... 29, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ) ... Chief Financial Officer has resigned.  The Company has hired ... who retired in December 2014, as full time interim ... successor.     Andy Ashworth began his ... a smooth transition.  Andy was the Company,s CFO from ...
(Date:7/29/2015)... 2015  AsureQuality and Ubiquitome have agreed to ... in food and primary production sectors. The collaboration ... device, the Freedom4. AsureQuality provides quality ... supermarket shelf for producers, processors and Competent Authorities ... disease control and pest management and surveillance programmes. ...
Breaking Biology Technology:Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10BioAmber Announces Change in Chief Financial Officer 2BioAmber Announces Change in Chief Financial Officer 3AsureQuality and Ubiquitome Partner on Applications for Mobile Molecular Food Safety Testing 2
Cached News: