HOME >> BIOLOGY >> NEWS
Genes discovered that regulate blood stem cell development

Boston--Researchers at Children's Hospital Boston have isolated a gene responsible for making blood stem cells. The findings appear in today's issue of the journal Nature. The gene, called cdx4, is responsible for establishing the location of blood cell formation in the developing embryo. Cdx4 works by altering the expression of HOX genes, which are involved in making the body plan. Surprisingly, the authors found that overexpression of cdx4 in zebrafish embryos, or in mouse embryonic stem cells, induces the new production of early blood cells. "We have been searching for genes in the zebrafish that participate in making blood stem cells," according to lead author, Leonard Zon, MD., of Children's Hospital Boston. "Now that we have these genes, we are one step closer to growing more blood stem cells. This will be potentially useful for patients with severe congenital anemias or bone marrow transplantation for cancer," adds Zon.

Scientists studied a mutant that had a severe anemia because it had few blood stem cells, and also had a tail defect. The zebrafish mutants generally die within seven to ten days after fertilization. They discovered the mutation in the cdx4 gene, which is associated with the early blood deficiency as well as abnormal developmental patterning, including aberrant hox gene expression. When researchers injected the mutants with hox genes, such as hoxb7a and hoxa9a, it resulted in almost complete rescue of the deficient blood cells. Another hox gene, hoxb6b showed some improvement, but hoxb8a did not have any effect on the blood defect. Researchers believe this shows blood cell development is dependent on the proper expression of these hox genes, and that overexpression of these genes can reverse a fatal deficiency in these blood cells. "These zebrafish findings will allow us to better understand normal blood development, with the hopes of eventually developing more effective treatments for these devastating blood diso
'"/>

Contact: Mary-Ellen Shay or Cara Birrittieri
cara.birrittieri@tch.harvard.edu
617-355-6420
Children's Hospital Boston
18-Sep-2003


Page: 1 2

Related biology news :

1. Genes expose secrets of sex on the side
2. Genes can influence both alcohol consumption and dependence
3. Genes may be central to cocaine addiction
4. Genes appear to play a role in development of chronic obstructive pulmonary disease
5. Genes make the marsh
6. Genes predict response of adult leukemia patients to chemotherapy
7. Genes influence memory in families with Alzheimers disease
8. Genes control severity of heart failure, study finds
9. Genes that regulate hearing link humans and fruit flies in new way
10. Genes that paint fly derrieres hint at convergence
11. Genes, Brain and Behavior Symposium April 16

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/1/2018)... ... ... Visikol CEO Dr. Michael Johnson has announced that through the rapid adoption ... far exceed its original 2018 revenue projections. , Over the last two years, ... tools, whole mount imaging techniques and advanced 3D cell culture assays ...
(Date:7/31/2018)... ... 31, 2018 , ... Lifecycle Biotechnologies, a leading life science ... this role, Mr. Muzek will lead the company-wide industrial strategic business development efforts ... , With over 20 years in business development, Mr. Muzek previously served as ...
(Date:7/29/2018)... (PRWEB) , ... July 29, 2018 , ... Dr. William ... biofield energy treated nutraceutical to improve overall immunity and to combat inflammation and autoimmune ... well as inflammation. The following data was reported:, Up ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... of a complex biological network, a depiction of a system of linkages and ... Dmitry Korkin, PhD, associate professor of computer science at Worcester Polytechnic Institute (WPI) ...
(Date:10/12/2017)... ... October 12, 2017 , ... DuPont ... today that they have entered into a multiyear collaboration to identify and characterize ... with additional tools for gene editing across all applications. , Under the terms ...
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces expanded coverage of ... newest module, US Hemostats & Sealants. , SmartTRAK’s US Market for Hemostats and ... synthetic sealants and biologic sealants used in surgical applications. BioMedGPS estimates the market ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
Breaking Biology Technology:
Cached News: