HOME >> BIOLOGY >> NEWS
Genes may be central to cocaine addiction

Two related genes that help control signaling between brain cells may be central components of the biological machinery that causes cocaine addiction, researchers have found. Peter Kalivas and his colleagues found that deleting either of two genes in the Homer family in mice produced the same symptoms seen in withdrawal from cocaine. The researchers said that their findings could open a new research pathway to understanding how genetic susceptibility to addiction interacts with environmental factors to cause addiction.

Studies by other researchers had suggested that the proteins produced by the Homer genes might play a role in cocaine addiction. Members of the family were known to be activated by cocaine, and reduction of activity in the genes had been linked to cocaine withdrawal.

So, to unequivocally test the involvement of the Homer genes in cocaine addiction, Kalivas and his colleagues individually knocked out the genes in mutant mice and tested the behavioral and biological effects. In one behavioral test, they placed the knockout mice in one of two linked chambers after cocaine administration. One was a "comfortable" darkened chamber with nesting material, and the other was an "uncomfortable" bare, white, brightly lit chamber. The researchers found that the mice lacking Homer1 or Homer2 genes showed greater preference for the chamber that they associated with receiving cocaine, compared to normal controls. The knockout mice also showed hyperactivity characteristic of withdrawal.

The Homer2 knockout animals also showed a greater motivation to self-administer cocaine by pressing a lever than did normal mice. Also, the knockout animals showed neurochemical changes associated with cocaine addiction, including reduced base levels of the neurotransmitter glutamate in the region of the brain known to be involved in addiction. They also showed increased levels when receiving cocaine. Such brain chemical changes are characteristic of addiction,
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
4-Aug-2004


Page: 1 2

Related biology news :

1. Genes expose secrets of sex on the side
2. Genes can influence both alcohol consumption and dependence
3. Genes appear to play a role in development of chronic obstructive pulmonary disease
4. Genes make the marsh
5. Genes predict response of adult leukemia patients to chemotherapy
6. Genes influence memory in families with Alzheimers disease
7. Genes control severity of heart failure, study finds
8. Genes that regulate hearing link humans and fruit flies in new way
9. Genes discovered that regulate blood stem cell development
10. Genes that paint fly derrieres hint at convergence
11. Genes, Brain and Behavior Symposium April 16

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/22/2020)... ... January 21, 2020 , ... ... validation strategies, supporting global regulatory applications, and executing global clinical trial operations. ... Journal as a fastest growing company, and ISO 9001:2015 certification with the ...
(Date:1/8/2020)... ... January 08, 2020 , ... ... offering complimentary overnight shipping to its nationwide practice network partners. Not only ... due to volume in its Network the biologics themselves are less expensive. , ...
(Date:1/7/2020)... ... 2020 , ... Myant Inc. , the pioneers in Textile Computing™, will ... life its vision of a world where textile-based interfaces knitted into everyday objects form ... and the physical IoT-enabled environment. The experience at Myant’s booth will challenge visitors to ...
Breaking Biology News(10 mins):
(Date:1/24/2020)... ... January 24, 2020 , ... ... RedySmart™ mass flow meters and controllers ideal for BioPharm OEMS. Sierra ... to antiquated rotameters. These thermal instruments employ high-precision MEMS (Micro-Electro Mechanical Systems) technology ...
(Date:1/22/2020)... ... January 21, 2020 , ... COBO Technologies and Cardea Bio ... partners have agreed to co-develop and market a portfolio of CRISPR QC products ... Over the longer-term, the parties aim to develop a COBO branded QC device ...
(Date:1/10/2020)... ... January 09, 2020 , ... GenScript Biotech Corp., ... Biotech Global Forum on Jan. 14 in San Francisco, coinciding with the JP ... and the Booming China Market," will feature gene and cell therapy leaders in ...
(Date:1/7/2020)... ... ... Vuja De Sciences (“Vuja De”), a biotechnology startup dedicated to developing cancer metastasis ... DVM, PhD, DACVIM (Onc), and Dr. Lee Helman, MD, to its Board of Directors. ... Chand and Lee as new directors. They will be of great help in advancing ...
Breaking Biology Technology:
Cached News: