HOME >> BIOLOGY >> NEWS
Genes may be central to cocaine addiction

Two related genes that help control signaling between brain cells may be central components of the biological machinery that causes cocaine addiction, researchers have found. Peter Kalivas and his colleagues found that deleting either of two genes in the Homer family in mice produced the same symptoms seen in withdrawal from cocaine. The researchers said that their findings could open a new research pathway to understanding how genetic susceptibility to addiction interacts with environmental factors to cause addiction.

Studies by other researchers had suggested that the proteins produced by the Homer genes might play a role in cocaine addiction. Members of the family were known to be activated by cocaine, and reduction of activity in the genes had been linked to cocaine withdrawal.

So, to unequivocally test the involvement of the Homer genes in cocaine addiction, Kalivas and his colleagues individually knocked out the genes in mutant mice and tested the behavioral and biological effects. In one behavioral test, they placed the knockout mice in one of two linked chambers after cocaine administration. One was a "comfortable" darkened chamber with nesting material, and the other was an "uncomfortable" bare, white, brightly lit chamber. The researchers found that the mice lacking Homer1 or Homer2 genes showed greater preference for the chamber that they associated with receiving cocaine, compared to normal controls. The knockout mice also showed hyperactivity characteristic of withdrawal.

The Homer2 knockout animals also showed a greater motivation to self-administer cocaine by pressing a lever than did normal mice. Also, the knockout animals showed neurochemical changes associated with cocaine addiction, including reduced base levels of the neurotransmitter glutamate in the region of the brain known to be involved in addiction. They also showed increased levels when receiving cocaine. Such brain chemical changes are characteristic of addiction,
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
4-Aug-2004


Page: 1 2

Related biology news :

1. Genes expose secrets of sex on the side
2. Genes can influence both alcohol consumption and dependence
3. Genes appear to play a role in development of chronic obstructive pulmonary disease
4. Genes make the marsh
5. Genes predict response of adult leukemia patients to chemotherapy
6. Genes influence memory in families with Alzheimers disease
7. Genes control severity of heart failure, study finds
8. Genes that regulate hearing link humans and fruit flies in new way
9. Genes discovered that regulate blood stem cell development
10. Genes that paint fly derrieres hint at convergence
11. Genes, Brain and Behavior Symposium April 16

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2019)... ... 2019 , ... Noblis, Inc., a leading provider of science, ... and Methods for SNP Analysis and Genome Sequencing.” Noblis’ new system and methods ... bioinformatic analyses, including SNP calling, metagenomic analysis, and conserved and signature sequence detection. ...
(Date:4/17/2019)... ... April 17, 2019 , ... ... other services to clinical trial sponsors, has entered into a multi-year agreement with ... enable Quartesian, a member of Medrio’s Certified Partner Program, to leverage the full ...
(Date:4/16/2019)... NEW YORK (PRWEB) , ... April 16, 2019 ... ... the Top 50 Healthcare Technology CEOs of 2019 . An extensive process ... the fields of medical devices, biotech, healthcare analytics, healthcare software and other related ...
Breaking Biology News(10 mins):
(Date:4/12/2019)... ... April 12, 2019 , ... ... neurotechnology and will educate about innovative tools and devices being used to enhance ... for more information. , This segment of Advancements will focus on Sound for ...
(Date:4/9/2019)... ... April 09, 2019 , ... USDM Life Sciences ... life sciences organizations to accelerate innovation and maximize productivity, announces that nearly 100 ... 12 months. , USDM’s Cloud Assurance is a managed subscription service ...
(Date:4/8/2019)... SOUTH JORDAN, Utah and BOSTON (PRWEB) , ... ... ... leader in delivering cloud-based enterprise-class unified communications and collaboration solutions, announced today the ... provides integration to an unprecedented range of business and contact-orientated applications while ...
(Date:4/4/2019)... ... April 02, 2019 , ... ... would be releasing it’s latest field-ready solution for performing PCR, RT-PCR, qPCR, and ... Franklin™ pays homage to Rosland Franklin, an English chemist and X-ray crystallographer who ...
Breaking Biology Technology:
Cached News: