HOME >> BIOLOGY >> NEWS
Genes predict response of adult leukemia patients to chemotherapy

(WASHINGTON, DC, March 19, 2004) Genes can indicate which adult leukemia patients will respond to therapy and what the duration of their remission will be, according to a new study published in the April 1, 2004, issue of Blood, the official journal of the American Society of Hematology.

Researchers from the Dana-Farber Cancer Institute in Boston, Mass., and the University "La Sapienza" in Rome studied 33 patients that had all been recently diagnosed with adult T-cell acute lymphocytic leukemia (T-ALL), a type of cancer in which the body makes too many T lymphocytes.

"The present study investigates, for the first time, the identification of gene expression profiles associated with both short-term and long-term outcome in adult patients with T-ALL. While approximately 70 percent of pediatric patients with T-ALL have excellent long-term response to intensive chemotherapy, adult patients have a much less favorable outcome. Previously, this poor prognosis of adult T-ALL patients had not been attributed to specific genetic signatures," according to Jerome Ritz, M.D., of the Dana-Farber Cancer Institute, co-senior author of the study. Robin Foa, M.D., from the University "La Sapienza," also served as senior author.

Using microarray technology, a technique that can evaluate the expression of thousands of genes at once, researchers were able to compare the gene expression profiles of the patients who responded to chemotherapy to those who did not. Through gene expression profiling a determination of which genes in a cell or group of cells are active the scientists identified a single gene, IL-8, that was highly expressed in T-ALL cells that were resistant to treatment. Researchers also discovered a set of 30 genes that were highly expressed in leukemic cells from patients who achieved complete remission.

A model based on the expression of three genes AHNAK, TTK, and CD2 was also found to be highly predictive of the duration of rem
'"/>

Contact: Aislinn Raedy
araedy@hematology.org
202-776-0544
American Society of Hematology
19-Mar-2004


Page: 1 2

Related biology news :

1. Genes expose secrets of sex on the side
2. Genes can influence both alcohol consumption and dependence
3. Genes may be central to cocaine addiction
4. Genes appear to play a role in development of chronic obstructive pulmonary disease
5. Genes make the marsh
6. Genes influence memory in families with Alzheimers disease
7. Genes control severity of heart failure, study finds
8. Genes that regulate hearing link humans and fruit flies in new way
9. Genes discovered that regulate blood stem cell development
10. Genes that paint fly derrieres hint at convergence
11. Genes, Brain and Behavior Symposium April 16

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/6/2017)... Forecasts by Product Type (EAC), Biometrics, Card-Based ... & Logistics, Government & Public Sector, Utilities / Energy ... Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality & ... for a definitive report on the $27.9bn Access Control ... ...
(Date:4/4/2017)... YORK , April 4, 2017   EyeLock ... today announced that the United States Patent and Trademark ... patent broadly covers the linking of an iris image ... same transaction) and represents the company,s 45 th ... latest patent is very timely given the multi-modal biometric ...
(Date:3/30/2017)... March 30, 2017 Trends, opportunities and forecast ... behavioral), by technology (fingerprint, AFIS, iris recognition, facial recognition, ... others), by end use industry (government and law enforcement, ... and banking, and others), and by region ( ... Asia Pacific , and the Rest ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for ... June 2018 in San Francisco, CA. The Summit brings together current and former FDA ... board directors and government officials from around the world to address key issues in ...
(Date:10/11/2017)... INDIANAPOLIS , Oct. 11, 2017  VMS BioMarketing, a ... of a nationwide oncology Clinical Nurse Educator (CNE) network, which ... growing need for communication among health care professionals to enhance ... physicians, nurses, office staff, and other health care professionals to ... for breast cancer. ...
(Date:10/11/2017)... ... ... Disappearing forests and increased emissions are the main causes of the evolving ... those living in larger cities are affected by air pollution related diseases. , That ... countries globally - decided to take action. , “I knew I had to take ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer ... treatment of osteosarcoma. SBT-100 is able to cross the cell membrane and bind ...
Breaking Biology Technology:
Cached News: