HOME >> BIOLOGY >> NEWS
Genes that regulate hearing link humans and fruit flies in new way

MADISON -- Researchers at the University of Wisconsin Medical School have found genetic evidence linking humans and fruit flies in a new way: through their hearing. The link offers the future possibility that the insect's auditory system may serve as a model for understanding human deafness and other hearing disorders.

The scientists found that a mutated fruit fly gene controlling hearing and the mutated human counterpart gene both produced similar consequences: hearing loss as well as limb deformities and genital abnormalities. The mutated human gene is responsible for a disorder called Townes-Brocks' syndrome. The unexpected finding was published in the Proceedings of the National Academy of Sciences Online (Sept. 2, 2003).

"We were very surprised to learn about this specific genetic similarity," said Grace Boekhoff-Falk, PhD, associate professor of anatomy, who led the study. "Developmental biologists have known that there are remarkable parallels between fruit fly and human genetics, but the parallels have been restricted to tissues and organs that existed before the evolutionary divergence of vertebrates and invertebrates, which occurred more than 600 million years ago."

Sensing mechanisms that helped ancient organisms function were thought to exist before that divergence, Boekhoff-Falk explained, but not the ability to hear. Until now, the conventional wisdom has been that hearing evolved separately in vertebrates and invertebrates. "Our data supports the novel idea that hearing already existed 600 million years ago," she said.

The fruit fly (Drosophila melanogaster) has been the object of scientific study for a century, providing fundamental information on the way genes are transmitted and the effects of genetic mutations. In the past 15 years or so, it has become clear that many genes occurring in humans are also found in fruit flies.

Some six years ago scientists were excited to find that the same gene regulates ey
'"/>

Contact: Dian Land
dj.land@hosp.wisc.edu
608-263-9893
University of Wisconsin-Madison
9-Oct-2003


Page: 1 2 3

Related biology news :

1. Genes expose secrets of sex on the side
2. Genes can influence both alcohol consumption and dependence
3. Genes may be central to cocaine addiction
4. Genes appear to play a role in development of chronic obstructive pulmonary disease
5. Genes make the marsh
6. Genes predict response of adult leukemia patients to chemotherapy
7. Genes influence memory in families with Alzheimers disease
8. Genes control severity of heart failure, study finds
9. Genes discovered that regulate blood stem cell development
10. Genes that paint fly derrieres hint at convergence
11. Genes, Brain and Behavior Symposium April 16

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2019)... ... June 13, 2019 , ... KICVentures announced today its plans ... Orthopedic and Pain Management-Driven ASC Conference in Chicago on Thursday, June 13th at 6:30 ... Dr. Chicago, IL in the 3rd floor Ticino Hospitality room in space #74T. , ...
(Date:6/11/2019)... ... 10, 2019 , ... Improved Pharma LLC announces the publication of “Predictive and ... The article was published online on April 29th, 2019. The authors are Stephen ... Chen of Purdue University. , The article is the most recent addition to a ...
(Date:6/6/2019)... ... June 05, 2019 , ... Ziegler, a ... advisor to Pathologists Bio-Medical Laboratories (PBM) on its recent acquisition by PathGroup. ... that provides services to more than one dozen hospitals and surgery centers in ...
Breaking Biology News(10 mins):
(Date:6/18/2019)... ... June 17, 2019 , ... ... entered into an agreement for production and manufacturing of GMP-grade adeno-associated virus (AAV) ... rhodopsin-mediated autosomal dominant retinitis pigmentosa (RHO-adRP) and IC-200 for the treatment of BEST1 ...
(Date:6/11/2019)... CITY, Calif. (PRWEB) , ... June 10, 2019 ... ... (IOPP) today announced IOPP will add 80 of its scientific journals to DeepDyve’s ... of physics-related content to DeepDyve’s continually expanding library of more than 20 million ...
(Date:5/31/2019)... ... May 29, 2019 , ... For many years, the primary forms ... cancer demand breakthrough therapies. Advances in immuno-oncology have led to the advent of Chimeric ... with engineered T cell receptors known as “CARs”. The CAR enables the final product ...
(Date:5/22/2019)... ... 22, 2019 , ... Artemis (formerly Agrilyst), the leading enterprise Cultivation ... round co-led by Astanor Ventures and Talis Capital with participation ... iSelect Fund . The company has raised $11.75m to date and will use the ...
Breaking Biology Technology:
Cached News: