HOME >> BIOLOGY >> NEWS
Genes-to-protein connection may have new twist

DNA's protein-building instructions may be able to combine in an unexpected way, increasing the number of possible proteins that can be generated from a given number of genes, according to a report in this week's Nature.

The new finding may have important implications for scientists puzzled by last week's announcement that an initial survey of the human genetic code had found an unexpectedly small number of genes.

Traditional scientific thinking supposes that instructions for building a protein are encoded on one strand of the double-stranded DNA molecule. Researchers at The Johns Hopkins University's Kreiger School of Arts and Sciences identified a fruit fly protein whose instructions follow one strand of the DNA molecule, but also include a segment that follows the opposite strand, which "reads" in the opposite direction.

"We've known for some time that one gene can make multiple protein products," says Victor Corces, chairman of biology and an author of the paper. "The process we're reporting on, which is called trans-splicing, increases even further the possibility of making additional protein products from just two genes."

Trans-splicing had been seen before in a few genes in plant cells and microorganisms, but had never before been shown to be essential to the function of an important protein.

Corces and his co-authors found the trans-splicing while studying the fruit fly gene known as mod (mdg4). They had identified two mutations that could disrupt the function of the gene, and showed that putting either of those mutations in both of the fruit fly's two copies of mod(mdg4) disabled a critical protein made by the gene.

However, when they placed one type of fatal mutation in one copy of the gene and a different kind of fatal mutation in the other copy, the critical protein continued to be made.

"We didn't understand what we were seeing initially, and had assum
'"/>

Contact: Michael Purdy
mcp@jhu.edu
410-516-7160
Johns Hopkins University
21-Feb-2001


Page: 1 2 3

Related biology news :

1. Molecule awakens and maintains neural connections
2. The Mediterranean connection: ecological effects of El Nio in the Northern hemisphere
3. OHSU researchers discover possible connection between infant hormone exposure, obesity
4. Gene essential for development of normal brain connections resulting from sensory input discovered
5. K-State professor examines connections between food, culture and psychology in new book
6. Drug-naive schizophrenia: The dopamine connection
7. New study clarifies connection of brain and heart failure
8. New studies reveal connections between oceanographic processes and rockfish populations
9. Researchers find a genetic connection in Sudden Infant Death Syndrome (SIDS)
10. Clonal human (hNT) neurons re-establish connection in rats with severe spinal cord injury
11. Researchers uncover biochemical connection between high-fat diets and increased colon-cancer risk

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/5/2020)... ... March 05, 2020 , ... ... Test™ technology . The AlphaSTEM Test™ is the first, and still only, ... Other technologies that attempt to provide information about the number and quality ...
(Date:3/4/2020)... ... March 04, 2020 , ... ... to apply to the MedTech IGNITE program’s 2020 IGNITE Cohort. The MedTech IGNITE ... to attract and nurture the next generation of medtech founders and entrepreneurs. IGNITE ...
(Date:3/4/2020)... ... March 04, 2020 , ... RoosterBio Inc., a ... bioprocess systems, announces today a significant milestone in the regenerative medicine field with ... patient has been treated by RoosterBio’s pharmaceutical customer with an Investigational New Drug ...
Breaking Biology News(10 mins):
(Date:3/13/2020)... ... March 12, 2020 , ... Today, ... Ireland SFI Research Center (APC), a pioneer in the field of microbiome science, ... a significant role in human health, based at University College Cork and Teagasc ...
(Date:3/4/2020)... ... March 04, 2020 , ... ... products and services, today announced the launch of its FleXpress™ high-throughput recombinant ... large number of antibodies at 80 ml scale. All production occurs in ...
(Date:2/28/2020)... ... February 26, 2020 , ... Designed primarily ... camera with a dedicated controller, thus simplifying setup, streamlining integration, and optimizing workflow. ... the first of Fastec Imaging’s new HS Series cameras to be released. The ...
(Date:2/21/2020)... TORONTO (PRWEB) , ... February 21, 2020 , ... Join ... – Southeast Region of Sequence, Inc. for an informative session ... , Design Flexibility: Key elements to incorporate into facility design to add manufacturing ...
Breaking Biology Technology:
Cached News: