HOME >> BIOLOGY >> NEWS
Genetic Alterations Linked To Cancer In Some Blood Samples

Using a recently developed molecular test, investigators at The Johns Hopkins University School of Medicine have detected genetic mutations specific to cancer in blood samples of six patients with head and neck cancer. Their findings are reported in the September issue of Nature Medicine.

"Although quite preliminary, these findings are interesting, because the presence of DNA alterations in the blood appears to be associated with large, advanced tumors and with cancer that has spread," says lead author David Sidransky, M.D., associate professor of otolaryngology/head and neck surgery, and oncology. Sidransky cautions that the test does not appear useful as a screening test for cancer. "But it might be helpful in patient management for identifying patients with a very poor prognosis who may benefit from aggressive therapy," he says.

The test works by identifying replication errors, or chromosomal deletions, in the DNA of cancer cells. In this study, the investigators examined DNA from patients' serum (a component of blood plasma) and compared this DNA pattern to normal DNA from circulating white blood cells. They found genetic alterations in the serum of 6 of 21 head and neck cancer patients that were identical to alterations from the tumor itself.

Examining disease outcomes, the researchers found that 4 out of the 6 patients with positive test results subsequently died of their cancer compared to only 3 of 15 with negative test results. Additionally, the three patients who developed distant metastases (disseminated cancer) were in the positive test group, further indicating that poor outcome may be associated with the presence of serum DNA alterations. These results must be confirmed in much larger clinical trials, Sidransky says.

The technique used in this study was developed by Sidransky's team and first used to detect cancer cells in urine. The test uses a series of DNA markers to seek out genetic mutations specific to each patient's cancer
'"/>

Contact: Karin Twilde
ktwilde@welchlink.welch.jhu.edu
410-955-1287
Johns Hopkins Medical Institutions
28-Aug-1996


Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic differences might help distinguish thyroid cancers
3. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
4. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
5. Genetically modified bacterium as remedy for intestinal diseases
6. Genetic analysis rewrites salamanders evolutionary history
7. Genetic map of important tree genes outlined
8. Genetically-engineered marathon mouse keeps on running
9. Genetic clues found for common congenital brain disorder
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. Genetic discovery could dramatically reduce need for liver transplants in children

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2019)... ... April 04, 2019 , ... PI’s ... providing 0.05 microns and 0.005 microns resolution, respectively. The new design allows for ... available, from fast DC-servo motors with linear encoders and low-friction ball-screws to simple ...
(Date:4/4/2019)... ... 2019 , ... The live session taking place ... connectivity between product risk management (ISO 14971) and the clinical risk management process ... With increasing global regulation and reimbursement challenges faced by medical device companies, it ...
(Date:4/1/2019)... ... April 01, 2019 , ... uBiome announces ... Related Conditions” by the US Patent and Trademark Office on January 1, 2019 ... by uBiome collaborators Dr. Zachary Apte, Dr. Daniel Almonacid, Dr. Jessica Richman, ...
Breaking Biology News(10 mins):
(Date:4/9/2019)... ... April 09, 2019 , ... USDM Life ... of life sciences organizations to accelerate innovation and maximize productivity, announces that nearly ... past 12 months. , USDM’s Cloud Assurance is a managed subscription ...
(Date:4/8/2019)... ... April 09, 2019 , ... To ... research center Chan Zuckerberg Biohub (CZ Biohub) has chosen Geneious Biologics to help ... part of CZ Biohub’s efforts to establish new approaches to inform the discovery ...
(Date:3/27/2019)... DIEGO (PRWEB) , ... March 27, 2019 , ... In ... to raise awareness on the importance of healthy meals and good nutrition. This ... as the Food Bank’s volunteer chef. , The first segment addressed the ...
(Date:3/19/2019)... ... March 19, 2019 , ... Cirrascale Cloud Services ®, ... extended its managed services offering to include NVIDIA® DGX™ systems. The company will ... the NVIDIA DGX-Ready Data Center program to deliver a Zero DevOps offering to ...
Breaking Biology Technology:
Cached News: