Genetic Makeup May Explain Why Some Women Smokers Develop Breast Cancer While Others Don't, UB Study in JAMA Reports

BUFFALO, N.Y. -- The answer to the question of whether smoking increases a women's risk of developing breast cancer may lie in her genes, researchers at the University at Buffalo and the National Cancer Institute have found.

Results of their study, the first to consider genetic variability as a factor in a person's breast-cancer susceptibility to the carcinogens in cigarette smoke, will be published in the Nov. 13 issue of the Journal of the American Medical Association.

The results showed that postmenopausal women born with the slow-acting gene for N-acetyltransferase (NAT2), an enzyme known to detoxify carcinogenic compounds in cigarette smoke, and who smoked more than a pack of cigarettes a day 20 years before diagnosis, had seven times the risk of developing breast cancer than women born with the fast-acting gene.

The risk was highest for women who began smoking before the age of 18.

The two genotypes are referred to as slow or fast acetylators. No relationship was found between genotypes and risk of breast cancer among premenopausal women who smoked.

Christine Ambrosone, Ph.D., who conducted the research while a post-doctoral fellow in the UB Department of Social and Preventive Medicine, said the findings provide new insight into why previous epidemiologic studies may have failed to show a consistent association between cigarette smoking and breast cancer, when the association is clear in many other organs.

"These findings on breast cancer require substantial replication, but the potential implications may be important," said Ambrosone, now a research epidemiologist at the National Center for Toxicological Research in Arkansas.

"If further investigations in other study populations reveal similar associations between NAT2 genotype, cigarette smoking and breast-cancer risk, it would be an important insight into the etiology of this disease," she added. "It is one more cancer site in wh

Contact: Lois Baker
University at Buffalo

Page: 1 2 3

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic differences might help distinguish thyroid cancers
3. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
4. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
5. Genetically modified bacterium as remedy for intestinal diseases
6. Genetic analysis rewrites salamanders evolutionary history
7. Genetic map of important tree genes outlined
8. Genetically-engineered marathon mouse keeps on running
9. Genetic clues found for common congenital brain disorder
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. Genetic discovery could dramatically reduce need for liver transplants in children

Post Your Comments:

(Date:8/14/2019)... TORONTO (PRWEB) , ... August 14, 2019 , ... Join ... live session on Tuesday, September 10, 2019 at 1pm EDT to learn ... stratification and effective management. , NAFLD is the most common diffuse liver disease, ...
(Date:8/14/2019)... ... August 14, 2019 , ... Gateway Genomics , ... children, announces inclusion in the 38th annual Inc. 500|5000 list of fastest ... To qualify, companies must have been founded and generating revenue by March 31, 2015. ...
(Date:8/14/2019)... ... ... Julie Reck of Veterinary Medical Center of Fort Mill has recently begun providing ... her own geriatric Australian Shepherd, Simon, was treated in June 2019 for osteoarthritis in his ... body was weak, and he struggled to play fetch and other games with his family. ...
Breaking Biology News(10 mins):
(Date:9/17/2019)... ... September 17, 2019 , ... ... in chronic diseases, announces today that the U.S. Patent and Trademark Office (USPTO) ... algorithm to rank drug class recommendations for hypertension treatment. , The patent ...
(Date:9/17/2019)... ... September 16, 2019 , ... A new episode of Advancements ... ET. Check local listings for more information on this program. , The show ... company from Singapore dedicated to developing advanced diagnostic technologies for the masses. Viewers ...
(Date:9/11/2019)... ... September 09, 2019 , ... Suvoda ... randomization and drug supply chain management, today announced its new technology partnership with ... industry. , “The integration between Veeva Vault EDC and our IRT will enable ...
(Date:9/9/2019)... , ... September 09, 2019 , ... Visikol CEO Dr. ... that was focused on how best to characterize 3D cell culture models. The inherent ... they are too thick and opaque to image through and therefore traditional wide-field or ...
Breaking Biology Technology:
Cached News: