HOME >> BIOLOGY >> NEWS
Genetic Stowaways May Contribute To Evolutionary Change: Adjacent Sequences Tag Along With Mobile DNA Elements, Study Shows

In the century and more since Charles Darwin first advanced his theory of evolution, the proposal has come to dominate biological understanding. Current thinking has it that new traits arise spontaneously through genetic mutations, and, if they promote the survival of the individual, the genes may be selected for in subsequent generations. Over time, significant changes in a species can occur in this way -- indeed, entirely new species may eventually appear.

In this age of molecular biology, highly specific new questions about the process of evolution are being framed. Scientists would like to know whether and how evolution operates at the molecular level in an organism's DNA.

Now, experiments performed at the University of Pennsylvania Medical Center have revealed a molecular mechanism that may be a significant driver of evolution in humans and other mammals. Certain retrotransposons -- bits of DNA able to copy themselves from one region of the genome to another -- are able to pick up flanking genetic sequences and then insert themselves and the tag-along DNA at new locations. A report on the new study will appear in the March 5, 1999, issue of Science. (Advance copies of the paper are available to reporters through the journal's news office at 202-326-6421.)

"These findings suggest a new mechanism for shuffling important genetic sequences -- exons, promoters, enhancers -- that may lie downstream from these active mobile DNA elements," says Haig H. Kazazian, MD, chairman of the department of genetics and senior author on the paper. "From an evolutionary perspective, here is a way to create novel genetic combinations. While many such changes might prove lethal, some could improve function in individuals, leading to a selective advantage for those individuals."

"Previously proposed explanations for how such rearrangements of DNA might occur have been rather murky," says lead author John V. Moran, PhD, now an
'"/>

Contact: Franklin Hoke
hokef@mail.med.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
5-Mar-1999


Page: 1 2 3

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic differences might help distinguish thyroid cancers
3. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
4. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
5. Genetically modified bacterium as remedy for intestinal diseases
6. Genetic analysis rewrites salamanders evolutionary history
7. Genetic map of important tree genes outlined
8. Genetically-engineered marathon mouse keeps on running
9. Genetic clues found for common congenital brain disorder
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. Genetic discovery could dramatically reduce need for liver transplants in children

Post Your Comments:
(Date:6/29/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/zj7h4f/latin_america ) ... Biomedical Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... America Biomedical Sensors market is estimated at $0.65 billion ... period 2014-2020 The near future will bring ... of each individual. These sensors can be set to ...
(Date:6/26/2015)... 26, 2015 ATL Technology, LLC, a top provider ... in single use solutions, headquartered in Springville, Utah ... California corporation with locations in ... Jose, Costa Rica ). This acquisition will ... with ATL Technology,s existing facility in Costa ...
(Date:6/25/2015)... 25, 2015 According to ... (Swipe & Area), Technology, Material (Optical Prism, Piezoelectric, ... Security & Others) & Geography - Global Forecast ... said market is expected to reach $14,500.07 Million ... Browse 76 market Tables and 109 ...
Breaking Biology News(10 mins):Latin America Biomedical Sensors Market Report 2015-2020 2ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4
(Date:6/25/2015)... 2015 Research ... the addition of the  "2015 Market ... Diagnostics Industry: Oncogenes, Biochemical Markers, Lymphokines, ... Labs, POC Locations"  report to ... http://photos.prnewswire.com/prnh/20130307/600769) , A new ...
(Date:6/25/2015)... ... June 25, 2015 , ... The American Brain Tumor ... Patient and Family Conference, Providing and Pursuing Answers: Advances in Research, Treatment and ... Suites Hotel, July 24-25, 2015. , “As advances in research accelerate the arrival ...
(Date:6/25/2015)... SAN DIEGO , June 25, 2015  BioMed ... that Illumina, Inc. (NASDAQ: ILMN ), a world ... unlocking the power of the genome, has signed a ... innovative scientific research building in Cambridge, England ... environment and access to the highly skilled workforce in ...
(Date:6/25/2015)... , June 25, 2015 ... Arzneimittel-Überprüfungs- und -Authentifizierungsdienstleistungen, führte am 24. und ... am Main das 2. Eco ... Informations-Veranstaltung zum Thema Sicherheit für Patienten in ...      (Logo: http://photos.prnewswire.com/prnh/20150610/748687) , ...
Breaking Biology Technology:Analysis of the Global Cancer Diagnostics Industry 2015-2020: Oncogenes, Biochemical Markers, Lymphokines, GFs, CSFs, Hormones, Immunohistochemical Stains 2Analysis of the Global Cancer Diagnostics Industry 2015-2020: Oncogenes, Biochemical Markers, Lymphokines, GFs, CSFs, Hormones, Immunohistochemical Stains 3Nationally Recognized Brain Tumor Experts to Speak at American Brain Tumor Association Patient and Family Conference 2BioMed Realty And Illumina Announce New Build-To-Suit Laboratory Building In Cambridge's Growing Life Science Cluster 2BioMed Realty And Illumina Announce New Build-To-Suit Laboratory Building In Cambridge's Growing Life Science Cluster 3Symposium zur Richtlinie über gefälschte Arzneimittel - mit Aegate in Deutschland 2Symposium zur Richtlinie über gefälschte Arzneimittel - mit Aegate in Deutschland 3
Cached News: