HOME >> BIOLOGY >> NEWS
Genetic Stowaways May Contribute To Evolutionary Change: Adjacent Sequences Tag Along With Mobile DNA Elements, Study Shows

In the century and more since Charles Darwin first advanced his theory of evolution, the proposal has come to dominate biological understanding. Current thinking has it that new traits arise spontaneously through genetic mutations, and, if they promote the survival of the individual, the genes may be selected for in subsequent generations. Over time, significant changes in a species can occur in this way -- indeed, entirely new species may eventually appear.

In this age of molecular biology, highly specific new questions about the process of evolution are being framed. Scientists would like to know whether and how evolution operates at the molecular level in an organism's DNA.

Now, experiments performed at the University of Pennsylvania Medical Center have revealed a molecular mechanism that may be a significant driver of evolution in humans and other mammals. Certain retrotransposons -- bits of DNA able to copy themselves from one region of the genome to another -- are able to pick up flanking genetic sequences and then insert themselves and the tag-along DNA at new locations. A report on the new study will appear in the March 5, 1999, issue of Science. (Advance copies of the paper are available to reporters through the journal's news office at 202-326-6421.)

"These findings suggest a new mechanism for shuffling important genetic sequences -- exons, promoters, enhancers -- that may lie downstream from these active mobile DNA elements," says Haig H. Kazazian, MD, chairman of the department of genetics and senior author on the paper. "From an evolutionary perspective, here is a way to create novel genetic combinations. While many such changes might prove lethal, some could improve function in individuals, leading to a selective advantage for those individuals."

"Previously proposed explanations for how such rearrangements of DNA might occur have been rather murky," says lead author John V. Moran, PhD, now an
'"/>

Contact: Franklin Hoke
hokef@mail.med.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
5-Mar-1999


Page: 1 2 3

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic differences might help distinguish thyroid cancers
3. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
4. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
5. Genetically modified bacterium as remedy for intestinal diseases
6. Genetic analysis rewrites salamanders evolutionary history
7. Genetic map of important tree genes outlined
8. Genetically-engineered marathon mouse keeps on running
9. Genetic clues found for common congenital brain disorder
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. Genetic discovery could dramatically reduce need for liver transplants in children

Post Your Comments:
(Date:3/23/2015)... SoundView Technology Group issues a new research update following the ... wallet. SoundView was one of the selected user groups to provide ... in multiple scenarios and outlets. Soundview shares ... both debit and credit card payments.  Soundview ... meets their plans in 2015, it would push our IV ...
(Date:3/20/2015)... Mar. 20, 2015 Research and Markets ... of the "India Sensors Market Forecast and ... The sensor market is projected to grow ... Consumer electronics, automotive, industrial and healthcare sectors ... the country. In addition, adoption of MEMS technology ...
(Date:3/19/2015)... Conn. , March 19, 2015  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, announces ... in a news clip that aired this week on ... ) . In a segment "The Next Great ... wallet ,a new way to pay, and ,a really big ...
Breaking Biology News(10 mins):Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3
(Date:3/30/2015)... 30, 2015 US-Australian drug discovery company, Novogen ... CanTx, Inc., and Yale University, on March 27 released ... was presented as an oral presentation by Professor ... to the 62 nd Annual Scientific Meeting of ... Francisco, CA. In both in ...
(Date:3/30/2015)... 2015    Intrexon Corporation (NYSE: ... Merck Serono, the biopharmaceutical business of Merck KGaA, ... an exclusive strategic collaboration and license agreement to ... cancer therapies. This collaboration advances Merck Serono,s comprehensive, ... the immune system,s natural ability to fight tumors. ...
(Date:3/30/2015)... OXFORD, England , March 30, 2015 /PRNewswire/ ... company developing novel biological drugs to treat cancer, ... appointment of Professor Sir John Bell , ... and Chairman of the Office for the Strategic ... Directors with immediate effect.      (Photo: ...
(Date:3/30/2015)... Wis. , March 30, 2015  FUJIFILM Holdings ... and Cellular Dynamics International, Inc. (CEO: Robert J. ... developer and manufacturer of fully functioning human cells in ... two companies have entered into a definitive agreement whereby ... to be followed by a second step merger. Fujifilm ...
Breaking Biology Technology:Yale University and Novogen Release Data on Cantrixil Mode of Action 2Yale University and Novogen Release Data on Cantrixil Mode of Action 3Yale University and Novogen Release Data on Cantrixil Mode of Action 4Intrexon and Merck Serono Announce Agreement for the Development and Commercialization of CAR-T Therapy 2Intrexon and Merck Serono Announce Agreement for the Development and Commercialization of CAR-T Therapy 3Intrexon and Merck Serono Announce Agreement for the Development and Commercialization of CAR-T Therapy 4Immunocore Appoints Professor Sir John Bell to its Board of Directors 2Immunocore Appoints Professor Sir John Bell to its Board of Directors 3Immunocore Appoints Professor Sir John Bell to its Board of Directors 4Immunocore Appoints Professor Sir John Bell to its Board of Directors 5Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 2Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 3Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 4Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 5Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 6Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 7Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 8
Cached News: