HOME >> BIOLOGY >> NEWS
Genetic basis for individual variations in the response to stress

The glucocorticoid component of the stress response has been the subject of intense scientific scrutiny because of the wide ranging pathological consequences resulting from excess glucocorticoid exposure, including mood and anxiety disorders, and cognitive impairment. Exposure to stress activates the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic adrenomedullary system, which are regulated by neuronal pathways, including the inhibitory GABAergic (gamma aminobutyric acid) system. Approximately 60% of the variance in glucocorticod levels may be attributable to genetic individual differences. In the present study, 56 healthy subjects underwent genotyping to determine the influence of the T1521C single nucleotide polymorphism (SNP) in the GABAA6 receptor subunit gene (GABRA6) on the hormonal and autonomic responses to psychological stress induced by the Trier Social Stress Test (TSST). Adrenocorticotropin (ACTH), cortisol, diastolic blood pressure, and mean blood pressure responses to the TSST were significantly greater in subjects homozygous for the T allele or heterozygous compared to subjects homozygous for the C allele. Behavioral data was collected employing the Revised NEO Personality Inventory (NEO PI-R); subjects homozygous for the C allele scored significantly lower on the Extraversion factor compared to subjects homozygous for the T allele or heterozygous. These results suggest that the T1521C polymorphism in the GABRA6 gene is associated with specific personality characteristics as well as a marked attenuation in hormonal and blood pressure responses to psychological stress.


'"/>

Contact: Aimee Midei
molecularpsychiatry@mednet.ucla.edu
310-206-6739
Molecular Psychiatry
24-Jun-2004


Page: 1

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic differences might help distinguish thyroid cancers
3. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
4. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
5. Genetically modified bacterium as remedy for intestinal diseases
6. Genetic analysis rewrites salamanders evolutionary history
7. Genetic map of important tree genes outlined
8. Genetically-engineered marathon mouse keeps on running
9. Genetic clues found for common congenital brain disorder
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. Genetic discovery could dramatically reduce need for liver transplants in children

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/22/2019)... ... November 21, 2019 , ... The inventors of a ... announced a major step forward with that therapy, known as SurVaxM. MimiVax LLC ... spun off from Roswell Park in 2012, has entered into a China-exclusive licensing ...
(Date:11/19/2019)... ARLINGTON, Va. (PRWEB) , ... November 19, 2019 , ... ... National Association of Chain Drug Stores (NACDS) Foundation to address substance use disorder ... . , Two individuals who have led to the program’s effectiveness in preventing ...
(Date:11/19/2019)... ... 2019 , ... The inaugural Cell & Gene Therapy Day takes place February ... event will be chaired by Dr Aiman Shalabi, VP R&D, Cell and Gene Therapies ... are witnessing significant innovation in cell and gene therapies, and we are at a ...
Breaking Biology News(10 mins):
(Date:12/4/2019)... ... ... A new survey by MedReps ( http://www.medreps.com ), a career site for medical ... companies to work for in 2020. , The 9th Annual Best Places ... community to identify which medical sales companies are currently the most sought-after in the ...
(Date:12/4/2019)... ... 2019 , ... A new study released today in STEM CELLS outlines how ... (scar tissue) buildup – also improves the range of motion of the affected limb. ... mice. , The tumor-destroying capabilities of radiation therapy can be a life saver ...
(Date:12/2/2019)... ... December 02, 2019 , ... Registration is now ... Meeting, which will be held at the Hynes Convention Center May 12-15, 2020, in ... therapy and brings together scientists, physicians, patient advocates, and other stakeholders with the goal ...
(Date:11/22/2019)... (PRWEB) , ... November 21, 2019 , ... Lajollacooks4u is ... building and cooking events company already scheduled several of its popular cooking classes and ... Parties. , The company’s Holiday Parties have been a favorite for companies ...
Breaking Biology Technology:
Cached News: