HOME >> BIOLOGY >> NEWS
Genetic differences might help distinguish thyroid cancers

COLUMBUS, Ohio Two types of thyroid cancer that are closely related and sometimes difficult to distinguish can be readily identified by differences in only a few genes, new research shows.

The study, by researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, used microarray analysis to show that papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) differ in the expression of only four or five genes.

Distinguishing between the two cancers is important because the malignancies behave differently and require different treatment. The research should also help scientists better understand the origins of the two diseases. The study is published in the a recent issue of the Journal of Clinical Oncology.

"This finding suggests a potentially very useful diagnostic aid in those rare instances where the pathologist cannot distinguish between FTC and PTC," says study leader Charis Eng, the Dorothy E. Klotz Chair of Cancer Research and director of OSU's clinical cancer genetics program.

Thyroid cancer represents one percent of all cancers in the United States and is the most common cancer of the endocrine hormone system. Over the last few years, thyroid cancer has risen at an alarming rate, Eng says. An estimated 23,600 new cases of thyroid cancer are expected this year, nearly two-thirds of which will occur in women, and 1,460 Americans are expected to die from the disease. PTC represents about 80 percent of all thyroid cancers, with FTC representing about 10 percent of cases.

Eng and her colleagues have shown that two distinct groups of genes are either over-active or under-active in PTC cells compared with normal thyroid cells. Genes that were inactive or under-active were more typical of FTC cells.

They further found that five genes could distinguish the two tumor types.

The researchers
'"/>

Contact: Darrell E. Ward
Ward-15@medctr.osu.edu
614-293-3737
Ohio State University
29-Sep-2004


Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
3. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
4. Genetically modified bacterium as remedy for intestinal diseases
5. Genetic analysis rewrites salamanders evolutionary history
6. Genetic map of important tree genes outlined
7. Genetically-engineered marathon mouse keeps on running
8. Genetic clues found for common congenital brain disorder
9. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
10. Genetic discovery could dramatically reduce need for liver transplants in children
11. Genetic model for devastating form of paraplegia suggests new treatments

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2019)... ... February 04, 2019 , ... uBiome, the leader microbial ... to help individuals understand how the gut microbes may increase the risk of ... eat foods that contain choline and L-carnitine, such as red meat and eggs, ...
(Date:2/2/2019)... FRANCISCO (PRWEB) , ... January 31, 2019 , ... ... leader in microbial genomics, has awarded microbiome research support in study design, planning, ... Behr, PhD, HCLD, Professor of Obstetrics and Gynecology, and Dr. Sara Vaughn, MD, ...
(Date:1/30/2019)... ... January 30, 2019 , ... ... supports high-growth, high-impact life science and biotechnology companies, announced today that it ... foundations and disease-focused venture funds to discuss their investment philosophies, explain their ...
Breaking Biology News(10 mins):
(Date:1/24/2019)... ... , ... Outsourcing trials to contract research organizations (CRO) can ... creation and management generally requires manual effort. Additionally, each vendor organizes tasks and ... can ultimately lead to study start delays and change orders because tasks were ...
(Date:1/20/2019)... ... ... The American Society of Gene & Cell Therapy (ASGCT) is proud to announce ... 2019. Designed by ASGCT committee volunteers in coordination with patient advocacy groups, the new ... the status and promise of gene and cell therapies. , Gene Therapy 101 ...
(Date:1/11/2019)... ... 2019 , ... Boekel Scientific launches its new Touch Screen ... This advanced and intuitive medical device was designed in conjunction with stationary and ... busiest donor stations with new-to-the industry features to improve efficiency and operational ease. ...
(Date:1/8/2019)... ... January 07, 2019 , ... ... into Noninvasix. This represents the second investment AngelMD has made into Noninvasix in ... Noninvasix is developing a patient monitor to directly, accurately, and noninvasively measure brain ...
Breaking Biology Technology:
Cached News: