HOME >> BIOLOGY >> NEWS
Genetic differences might help distinguish thyroid cancers

COLUMBUS, Ohio Two types of thyroid cancer that are closely related and sometimes difficult to distinguish can be readily identified by differences in only a few genes, new research shows.

The study, by researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, used microarray analysis to show that papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) differ in the expression of only four or five genes.

Distinguishing between the two cancers is important because the malignancies behave differently and require different treatment. The research should also help scientists better understand the origins of the two diseases. The study is published in the a recent issue of the Journal of Clinical Oncology.

"This finding suggests a potentially very useful diagnostic aid in those rare instances where the pathologist cannot distinguish between FTC and PTC," says study leader Charis Eng, the Dorothy E. Klotz Chair of Cancer Research and director of OSU's clinical cancer genetics program.

Thyroid cancer represents one percent of all cancers in the United States and is the most common cancer of the endocrine hormone system. Over the last few years, thyroid cancer has risen at an alarming rate, Eng says. An estimated 23,600 new cases of thyroid cancer are expected this year, nearly two-thirds of which will occur in women, and 1,460 Americans are expected to die from the disease. PTC represents about 80 percent of all thyroid cancers, with FTC representing about 10 percent of cases.

Eng and her colleagues have shown that two distinct groups of genes are either over-active or under-active in PTC cells compared with normal thyroid cells. Genes that were inactive or under-active were more typical of FTC cells.

They further found that five genes could distinguish the two tumor types.

The researchers
'"/>

Contact: Darrell E. Ward
Ward-15@medctr.osu.edu
614-293-3737
Ohio State University
29-Sep-2004


Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
3. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
4. Genetically modified bacterium as remedy for intestinal diseases
5. Genetic analysis rewrites salamanders evolutionary history
6. Genetic map of important tree genes outlined
7. Genetically-engineered marathon mouse keeps on running
8. Genetic clues found for common congenital brain disorder
9. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
10. Genetic discovery could dramatically reduce need for liver transplants in children
11. Genetic model for devastating form of paraplegia suggests new treatments

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... ... July 30, 2020 , ... ... II contract awarded by the Joint Science & Technology Office—Chemical and Biological Defense ... to develop, optimize, and scale-up a highly efficient mammalian cell culture-based bioprocess suitable ...
(Date:7/22/2020)... SANTA BARBARA, Calif. (PRWEB) , ... July 21, ... ... consulting firm driving digital transformation and innovation in technology and compliance, announces a ... and medical device companies must ensure every layer of their technology stack complies ...
(Date:7/18/2020)... ... July 17, 2020 , ... Commercial launch readiness is ... ability to discover a COVID cure or vaccine, the global economic downturn will only ... pressure is not going away and capturing full value from every product launch is ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... reliable, solid-state radar transmitter systems that can be configured to drive Klystrons, TWTs, ... controller that can drive one or two switches in a push-pull configuration; yielding ...
(Date:7/31/2020)... ... ... eSource has long been touted as the solution to high data management ... reasons it did not take off as quickly as people initially expected, and where ... towards capturing data electronically for clinical trials and then repurposing it for downstream analysis, ...
(Date:7/22/2020)... ... ... Join experts from Reed Tech , Gary Saner, Sr. Manager, Information ... live webinar on Thursday, August 13, 2020 at 11am EDT (4pm BST/UK). ... Specifically, for medical devices, the NMPA has departments dealing with medical device registration (pre-market ...
(Date:7/18/2020)... DAYTON, Ohio (PRWEB) , ... July 16, 2020 ... ... clinical data solutions to aid in the early detection and prevention of high-burden ... partnership to enable US-based hospitals and healthcare organizations to utilize existing data in ...
Breaking Biology Technology:
Cached News: