HOME >> BIOLOGY >> NEWS
Genetic differences might help distinguish thyroid cancers

used microarray analysis, which reveals the activity levels of tens of thousands of genes at one time, to compare gene activity in cells from six PTC tumors, nine FTC tumors and 13 samples of normal thyroid tissue.

The PTC cells showed over-expression of genes known as CITED1, claudin-10 (CLDN10), and insulin-like growth factor binding protein 6 (IGFBP6). It also showed no change in two genes, caveolin-1 (CAV-1) or caveolin-2 (CAV-2). FTC cells, on the other hand, showed no expression by CLDN10 and low activity by IGFBP6 and/or by CAV1 and CAV2.

If verified in a larger number of tumors, these genes, in combination with other known genetic changes in thyroid cancer cells, form the basis for a valuable diagnostic tool, says Eng, a recipient of the Doris Duke Distinguished Clinical Scientist Award.

"Our work begins to elucidate the fundamental differences and similarities between these two types of thyroid cancer, which should help in the future to develop new therapies," Eng says.

Clinical testing for the genetic differences can be done using polymerase chain reaction (PCR) technology, which is far more available and far less costly than microarray analysis.

Other Ohio State researchers involved in the study were first author Micheala A. Aldred, Sandya Liyanarachchi, Natalia S. Pellegata, Sissy Jhiang, Ramana V. Davuluri and Albert de la Chapelle.


'"/>

Contact: Darrell E. Ward
Ward-15@medctr.osu.edu
614-293-3737
Ohio State University
29-Sep-2004


Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
3. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
4. Genetically modified bacterium as remedy for intestinal diseases
5. Genetic analysis rewrites salamanders evolutionary history
6. Genetic map of important tree genes outlined
7. Genetically-engineered marathon mouse keeps on running
8. Genetic clues found for common congenital brain disorder
9. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
10. Genetic discovery could dramatically reduce need for liver transplants in children
11. Genetic model for devastating form of paraplegia suggests new treatments

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... ... 27, 2020 , ... CrucialTrak, a global designer and manufacturer of biometric access ... (CEG) to market and sell its complete line of biometric readers and access ... infrastructure optimization solutions . , Brett Mason, CrucialTrak’s Director of Channel Sales for ...
(Date:5/28/2020)... ... May 28, 2020 , ... Actuate Therapeutics, ... their 1801 Phase 1/2 study (NCT03678883, EudraCT #: 2018-003739-32) will be presented at ... place virtually on May 29th, 2020. Dr. Benedito Carneiro, Brown University’s principal investigator ...
(Date:5/21/2020)... ... May 21, 2020 , ... ... background and medical screening, announces the launch of a testing service aimed ... safe. The new service is provided by ClearStar’s Medical Information Services (“MIS”) ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... 23, 2020 , ... Kerafast Inc. , developers of ... the availability of the Delta-G-VSV Pseudotyping System for coronavirus research applications. The system, ... SARS-CoV-2 viral entry and COVID-19 vaccine effectiveness at just biosafety level 2 (BSL-2) ...
(Date:6/23/2020)... ... June 22, 2020 , ... Dracen Pharmaceuticals Inc., announced today ... 22-24 during the American Association for Cancer Research Virtual meeting. One poster describes ... consistent single agent activity in KEAP1 mutant tumor models of NSCLC. ...
(Date:6/11/2020)... ... , ... Greffex, a leading genetic engineering company, with the ... vectors, recently announced a key manufacturing agreement with FUJIFILM Diosynth Biotechnologies to produce ... successful gene therapy delivery vehicle (vector) with broad applications for delivering treatments including ...
(Date:6/11/2020)... ... 2020 , ... Reducing carbon emissions has been and will continue to be ... market dips, ways to reduce CO2 is something we can’t avoid. , To ... biofuels being produced today are created from recycled cooking oil or crops. Unfortunately, these ...
Breaking Biology Technology:
Cached News: