HOME >> BIOLOGY >> NEWS
Genetic discovery could dramatically reduce need for liver transplants in children

CINCINNATI A new study published in the Journal of Clinical Investigation opens the door to the possibility of new treatments for children who suffer from biliary atresia, a deadly disease of infancy and the most common reason for liver transplantation in children. The new treatments could dramatically reduce the number of liver transplants performed on children every year.

Jorge Bezerra, M.D., a physician/researcher in the Division of Gastroenterology, Hepatology and Nutrition at Cincinnati Children's Hospital Medical Center, and research colleagues at Cincinnati Children's, discovered that in the early phases of biliary atresia, inflammatory genes are activated and control the obstruction of bile ducts in mice. The discovery "substantiates our initial observation in humans and opens the door for the future development of agents to control inflammation and progression of disease," Dr. Bezerra said.

Biliary atresia occurs in infants and usually becomes evident two to eight weeks after birth. Its cause has been unknown. Symptoms include unexplained jaundice, dark urine, clay-colored stools and weight loss. The disease destroys bile ducts in the liver, trapping bile, rapidly causing damage to liver cells and severe scarring.

Biliary atresia accounts for up to 50 percent of children who undergo liver transplantation. Although a surgical procedure is successful in many infants, three of every four children who have biliary atresia need a liver transplant before the age of 20. The total annual cost, including transplant care, of treating all infants with biliary atresia is estimated to be $65 million.

In a previous study published in The Lancet, Dr. Bezerra obtained biopsies of livers of 14 infants with biliary atresia. Using gene chip technology, he and the Cincinnati Children's research team discovered that in the early phases of biliary atresia, inflammatory genes are activated and immunoglobulin genes are suppressed, pointing
'"/>

Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
2-Aug-2004


Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic differences might help distinguish thyroid cancers
3. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
4. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
5. Genetically modified bacterium as remedy for intestinal diseases
6. Genetic analysis rewrites salamanders evolutionary history
7. Genetic map of important tree genes outlined
8. Genetically-engineered marathon mouse keeps on running
9. Genetic clues found for common congenital brain disorder
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. Genetic model for devastating form of paraplegia suggests new treatments

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... ... Gateway Genomics , a leading developer of direct-to-consumer genetic tests that ... Inc. 500|5000 list of fastest growing private companies, in the first year the ... generating revenue by March 31, 2015. Ranking in the list is determined by the ...
(Date:8/14/2019)... ... ... Julie Reck of Veterinary Medical Center of Fort Mill has recently begun providing ... her own geriatric Australian Shepherd, Simon, was treated in June 2019 for osteoarthritis in his ... body was weak, and he struggled to play fetch and other games with his family. ...
(Date:8/6/2019)... N.C. (PRWEB) , ... August 06, 2019 , ... ... (SCTM) identifies a computational modeling system that could have far-reaching implications for personalized ... partial least squares regression (PLSR), is able to predict which stem cell donors ...
Breaking Biology News(10 mins):
(Date:8/7/2019)... Ohio (PRWEB) , ... August 07, 2019 , ... Locus ... a breakthrough line of soil amendments (soil “probiotics”), including Rhizolizer ® , which ... a year—the largest impact any approach has offered to date. Results from the treatment ...
(Date:8/6/2019)... EDWARDSVILLE, Ill. (PRWEB) , ... August 06, 2019 ... ... to Southern Illinois University Edwardsville for the launch of a community project that ... , The three-year grant supports the project, entitled “A Youth-Led Citizen Science Network ...
(Date:7/23/2019)... , ... July 22, 2019 , ... ... companies with best-in-class services in the fields of 3D tissue imaging , ... learning , Visikol initially started back in 2013 as a products company. These ...
(Date:7/17/2019)... N.J. (PRWEB) , ... July ... ... announced a long-term strategic agreement for the development and manufacturing of Zolgensma® ... , Through this collaboration, AveXis, a Novartis company, will have dedicated manufacturing ...
Breaking Biology Technology:
Cached News: