HOME >> BIOLOGY >> NEWS
Genetic engineering could salvage once-promising anti-cancer agents

g the work in the June 11 issue of the Proceedings of the National Academies of Science.

To clone the genes, the researchers snipped the genome of the bacteria (Actinosynnema pretiosum) into small bits to create a genomic library. They used a gene that already had been cloned from another microorganism (Amycolatopsis mediterranei) as a reference to screen the library and find the genes needed for maytansinoid construction. Having access to the genes that control the formation of maytansinoids allows scientists to manipulate the structure of the anti-cancer agent at the DNA level.

The work, for which the UW has applied for a patent, allows for a detailed analysis of maytansinoid formation at both the genetic and biochemical levels. It also sets the stage to modify maytansinoids through genetic engineering, so they are less toxic to humans, are more effective against cancer and bond easily with delivery agents.

Several companies are in discussions about the possibility of using the research to combine maytansinoids with antibodies that target tumors. The antibodies would search out specific cancer antigens attach only to cancer cells, Yu said. The maytansinoids then can enter the cancer cells and destroy them without damaging surrounding healthy tissue.

"It is a warhead strategy," he said.

The work has provided researchers with a number of options other than simply deciphering the biosynthesis of pre-existing compounds, Yu said. Manipulating the structure, he said, ultimately could lead to development of more effective cancer drugs.


'"/>

Contact: Vince Stricherz
vinces@u.washington.edu
206-543-2580
University of Washington
10-Jun-2002


Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic differences might help distinguish thyroid cancers
3. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
4. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
5. Genetically modified bacterium as remedy for intestinal diseases
6. Genetic analysis rewrites salamanders evolutionary history
7. Genetic map of important tree genes outlined
8. Genetically-engineered marathon mouse keeps on running
9. Genetic clues found for common congenital brain disorder
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. Genetic discovery could dramatically reduce need for liver transplants in children

Post Your Comments:
(Date:7/21/2014)... have meaning? If you say "dog" to a friend, ... University philosopher Elliott Wagner aims to address these types ... long-standing philosophical questions about semantic meaning. Wagner, assistant professor ... are collaborating to use game theory to analyze communication ... a cappuccino at a coffee shop, I usually don,t ...
(Date:7/21/2014)... to climate change, due to greenhouse gasses emitted by ... the rise and that beef cattle are responsible for ... animals. It is published by Climactic Change . ... it comes to climate change. It is released by ... portion of greenhouse gas totals. But methane and nitrous ...
(Date:7/21/2014)... the strength of immune response, rather than with the ... the virus, might be a better way to reduce ... Washington, Seattle. She and her collaborators have now taken ... H7N9 influenza, and their work has already led to ... strain. The research is published ahead of print in ...
Breaking Biology News(10 mins):Philosopher uses game theory to understand how words, actions acquire meaning 2Climate: Meat turns up the heat 2Potential new flu drugs target immune response, not virus 2
(Date:7/18/2014)... N.Y. , July 18, 2014 Regeneron ... its second quarter 2014 financial and operating results on ... open.  The Company will host a conference call and ... Conference Call InformationTo access this call, ... link to the webcast may be accessed from the ...
(Date:7/18/2014)... is, most of the atoms in our environment are ... outer parts of atoms equals the number of protons ... more electrons are plucked away from the atoms, the ... the nucleus. This enhanced pull, causing the atoms ... less vulnerable to the distractions of their environment, making ...
(Date:7/18/2014)... (PRWEB) July 18, 2014 Global ... with US offices in Cambridge, MA, announces the ... Assay and Software product that leverages the power ... the Illumina® MiSeq sequencing platform. The assay and ... Children’s Hospital of Philadelphia (CHOP) and will include ...
(Date:7/18/2014)... 18, 2014 The International Wheat Genome Sequencing ... a draft sequence of the bread wheat genome. The ... and evolution of the large, complex genome of the ... genetic blueprint is an invaluable resource to plant science ... at their disposal a set of tools enabling them ...
Breaking Biology Technology:Highly charged ions 2Highly charged ions 3Highly charged ions 4Omixon Launches Holotype HLA for NGS-based HLA Genotyping 2Omixon Launches Holotype HLA for NGS-based HLA Genotyping 3Genetic Blueprint of Bread Wheat Genome Unveiled 2Genetic Blueprint of Bread Wheat Genome Unveiled 3
Cached News: