Genetic fingerprinting improves diagnosis and treatment of sarcoma

Orlando, FL, May 19, 2002 - Decades of research into the cell's molecular mechanics have produced a promising arsenal of drugs that selectively attack cancer cells and leave the surrounding normal tissue relatively untouched.

Because these drugs target tumors based on their unique genetic characteristics, the ability to accurately identify a cancer's biological makeup is key.

New research being presented at the 38th Annual Meeting of the American Society of Clinical Oncology demonstrates that a new technique enables doctors to distinguish the molecular differences among many subtypes of adult soft-tissue sarcoma, a type of cancer that is often difficult to diagnose and treat.

Using a sophisticated technology called oligonucleotide array analysis, researchers developed a genetic fingerprint of each sarcoma, which will ultimately improve the diagnosis of this varied group of tumors and aid the development of targeted therapies for this disease.

"Our findings suggest that genetic fingerprinting of adult sarcomas will be useful in cases where pathologists disagree about a diagnosis or when the appearance of tumor cells does not conclusively link them to a particular subtype," said Robert Maki, MD, a medical oncologist at Memorial Sloan-Kettering Cancer Center and lead investigator of the study.

Soft-tissue sarcomas originate in tissues such as fat, muscles, nerves, tendons, and blood vessels.

According to the American Cancer Society, approximately 8,700 new cases of soft-tissue sarcoma are diagnosed each year in adults and children in the United States. Treatment usually involves surgery to remove the tumor followed by radiation therapy, and sometimes chemotherapy.

Many sarcomas look almost identical under the microscope, making it difficult to distinguish between certain subtypes and presenting unique challenges in detection and treatment.

For years, many pa

Contact: Esther Carver
Memorial Sloan-Kettering Cancer Center

Page: 1 2 3

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic differences might help distinguish thyroid cancers
3. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
4. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
5. Genetically modified bacterium as remedy for intestinal diseases
6. Genetic analysis rewrites salamanders evolutionary history
7. Genetic map of important tree genes outlined
8. Genetically-engineered marathon mouse keeps on running
9. Genetic clues found for common congenital brain disorder
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. Genetic discovery could dramatically reduce need for liver transplants in children

Post Your Comments:

(Date:8/19/2019)... ... August 19, 2019 , ... Since ... use of ultra-thin two dimensional slices which are placed on microscope slides, stained ... complex tissues and complicated features such as vasculature and thus researchers in the ...
(Date:8/15/2019)... ... ... Deep Science Ventures (DSV), a new paradigm for applied science, today announced ... 100 companies over the next 10 years to address the urgent need for new ... was founded to create a better method for launching science companies; one that takes ...
(Date:8/15/2019)... ... , ... Serialization deadlines in the US and European Union ... becomes fully applied in the United States in 2023, pharmaceutical companies are scrutinizing ... most regulations?including the Drug Supply Chain Security Act (DSCSA)?have required minimal system capabilities. ...
Breaking Biology News(10 mins):
(Date:6/18/2019)... ... June 17, 2019 , ... IVERIC bio, ... an agreement for production and manufacturing of GMP-grade adeno-associated virus (AAV) vector for ... dominant retinitis pigmentosa (RHO-adRP) and IC-200 for the treatment of BEST1 related retinal ...
(Date:6/11/2019)... MONTREAL (PRWEB) , ... June 10, 2019 , ... ... growth of its distribution network with the appointment of Biofeedback Tech Ltd ... physiological monitoring systems are an essential part of many therapeutic treatments and clinical ...
(Date:6/11/2019)... Md. and ROANOKE, Va. (PRWEB) , ... June ... ... care optimized for microlearning engagement, and Carilion Clinic, a national leader in opioid ... the latest in virtual care. , Mytonomy recently deployed its virtual ...
(Date:6/6/2019)... (PRWEB) , ... June 05, 2019 , ... WCCT ... and medical device industries, announced today that they will be receiving 3 awards at ... Diego, CA. WCCT received 2 awards in the categories of overall Quality and Compatibility ...
Breaking Biology Technology:
Cached News: