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Genetic info of cloned pigs may help babies before birth

The birth of the first cloned animals in North Carolina may soon lead to advances in animal and human health, particularly the prevention of intrauterine growth retardation (IUGR).

Dr. Jorge Piedrahita and a team of researchers at North Carolina State University's College of Veterinary Medicine have successfully cloned a Duroc pig. The resulting two piglets were recently weaned and are in excellent health. The births themselves are not particularly remarkable for Piedrahita, since he has cloned animals in previous research projects it's the benefits to animal and human health that are noteworthy.

Piedrahita is investigating instances of damage to genes during cloning, damage that can also occur naturally. "The cloning work we did here with pigs showed us that certain genes were dis-regulated or damaged and it showed us that some of those genes so called imprinted genes could be important to fetal development. We looked to see if some of the affected genes were imprinted in humans," Piedrahita said. It turns out that Piedrahita's group discovered two new imprinted genes that have never been reported before.

The implications are far reaching. "What all of this is telling us is that the mechanisms that are dis-regulating genes in the pigs can be translated to what is happening in humans," Piedrahita said. Researchers tested the top 42 genes affected by imprinting in pigs and discovered that all 42 of those genes are also expressed in human placentas.

IUGR is a condition that affects between five and eight percent of all human births in the United States and results in low birth-weight. "These children then have a high predisposition to a host of other illnesses and diseases -- coronary heart diseases, hypertension and diabetes. It's a far-reaching problem and there is really no clear understanding of why this happens," Piedrahita said.

Piedrahita's lab analyzed the genes of the pigs and came up with a list of candidate gene
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Contact: Dr. Jorge Piedrahita
jorge_piedrahita@ncsu.edu
919-515-7407
North Carolina State University
5-Dec-2003


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