HOME >> BIOLOGY >> NEWS
Genetic mutation, most common in Ashkenazi Jews, more than doubles cancer risk

Note: This release has been updated since its original posting.

A genetic mutation, most often found in people descended from Ashkenazi Jews, can double or even triple the risk of colorectal cancer, according to new data from an international study published in the Sept. 20 issue of Science.

The relationship between mutations in a gene called BLM and increased susceptibility to colorectal cancer was discovered independently by two teams of scientists who analyzed DNA from nearly 3,100 people of Ashkenazi Jewish ancestry living in northern Israel and New York City. The mutation is found in about one percent of individuals descended from a closely related ethnic group, called Ashkenazi Jews, who formerly lived in Eastern Europe.

When this mutation is inherited from both parents, it causes a serious disorder called Bloom syndrome, which greatly increases an individuals predisposition to cancer, said Stephen B. Gruber, M.D., Ph.D., director of clinical cancer genetics at the University of Michigans Comprehensive Cancer Center and first author of the Science paper.

Until now, carriers of one mutant copy were thought to have no increased cancer risk. But our data show that people who inherit the mutation from just one parent face a two- to three-times greater risk for colorectal cancer, Gruber added.

The Israeli data in the Science paper are the first to be published from the Molecular Epidemiology of Colorectal Cancer (MECC) study a collaboration between Gruber and Gad Rennert, M.D., Ph.D., of the Technion-Israel Institute of Technology Faculty of Medicine and Carmel Medical Center in Haifa, Israel. Rennert also directs the Clalit Health Services National Cancer Control Center in Israel and is the corresponding author of the Science paper.

New York data for the study were collected independently by scientists at Memorial Sloan-Kettering Cancer Center working under the direction of Kenneth Offit, M.D., and Nathan A. Ellis
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-615-6912
University of Michigan Health System
19-Sep-2002


Page: 1 2 3

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic differences might help distinguish thyroid cancers
3. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
4. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
5. Genetically modified bacterium as remedy for intestinal diseases
6. Genetic analysis rewrites salamanders evolutionary history
7. Genetic map of important tree genes outlined
8. Genetically-engineered marathon mouse keeps on running
9. Genetic clues found for common congenital brain disorder
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. Genetic discovery could dramatically reduce need for liver transplants in children

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2019)... ... June 14, 2019 , ... ... customer, will deliver a joint presentation with Versiti’s CIO at the Healthcare ... the Rosen Shingle Creek Resort. , Versiti Vice President and Chief Information Officer, ...
(Date:6/11/2019)... ... June 10, 2019 , ... Improved Pharma LLC announces ... 2019 issue of AAPS PharmSciTech. The article was published online on April 29th, 2019. ... Pharma, along with Xiaoming Sean Chen of Purdue University. , The article is the ...
(Date:6/4/2019)... ... June 04, 2019 , ... ... appointment of Susan Murphy as the new President of Molecular Devices, replacing Greg ... Devices’ parent company, Danaher Corporation. , Since joining Molecular Devices in a scientific ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 30, 2019 , ... ... on Data Integrity on July 08-09, 2019 in Boston, MA. This peer recommended ... medical device organizations. , The training will kick off with a compendial treatment ...
(Date:5/15/2019)... , ... May 15, 2019 , ... Milton Hershey School® ... recognition for his work within the biomedical industry, where he is changing lives by ... devices. , “William Harding epitomizes the vision of our founders – Milton and ...
(Date:5/7/2019)... ... May 06, 2019 , ... "The new ... number of repositories being asked to store cellular products being used in ... contributors who are world leaders, who have shared their expertise in building and ...
(Date:5/2/2019)... ... May 02, 2019 , ... Stay on top of ... device and food industries. Access to all webinars is free, so be sure to ... your field! , Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL ...
Breaking Biology Technology:
Cached News: