HOME >> BIOLOGY >> NEWS
Genetic mutation, most common in Ashkenazi Jews, more than doubles cancer risk

Note: This release has been updated since its original posting.

A genetic mutation, most often found in people descended from Ashkenazi Jews, can double or even triple the risk of colorectal cancer, according to new data from an international study published in the Sept. 20 issue of Science.

The relationship between mutations in a gene called BLM and increased susceptibility to colorectal cancer was discovered independently by two teams of scientists who analyzed DNA from nearly 3,100 people of Ashkenazi Jewish ancestry living in northern Israel and New York City. The mutation is found in about one percent of individuals descended from a closely related ethnic group, called Ashkenazi Jews, who formerly lived in Eastern Europe.

When this mutation is inherited from both parents, it causes a serious disorder called Bloom syndrome, which greatly increases an individuals predisposition to cancer, said Stephen B. Gruber, M.D., Ph.D., director of clinical cancer genetics at the University of Michigans Comprehensive Cancer Center and first author of the Science paper.

Until now, carriers of one mutant copy were thought to have no increased cancer risk. But our data show that people who inherit the mutation from just one parent face a two- to three-times greater risk for colorectal cancer, Gruber added.

The Israeli data in the Science paper are the first to be published from the Molecular Epidemiology of Colorectal Cancer (MECC) study a collaboration between Gruber and Gad Rennert, M.D., Ph.D., of the Technion-Israel Institute of Technology Faculty of Medicine and Carmel Medical Center in Haifa, Israel. Rennert also directs the Clalit Health Services National Cancer Control Center in Israel and is the corresponding author of the Science paper.

New York data for the study were collected independently by scientists at Memorial Sloan-Kettering Cancer Center working under the direction of Kenneth Offit, M.D., and Nathan A. Ellis
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-615-6912
University of Michigan Health System
19-Sep-2002


Page: 1 2 3

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic differences might help distinguish thyroid cancers
3. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
4. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
5. Genetically modified bacterium as remedy for intestinal diseases
6. Genetic analysis rewrites salamanders evolutionary history
7. Genetic map of important tree genes outlined
8. Genetically-engineered marathon mouse keeps on running
9. Genetic clues found for common congenital brain disorder
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. Genetic discovery could dramatically reduce need for liver transplants in children

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/8/2019)... ... January 07, 2019 , ... ... solutions, is proud to welcome Thomas Kennedy as head of sales and business ... for PureWay. , Mr. Kennedy has previously worked for Johnson & Johnson Medical, ...
(Date:1/4/2019)... ... January 02, 2019 , ... Lifecycle Biotechnologies ... the life science tools and service supplier turned 40 in 2018 and for ... catalog features not just part numbers like most catalogs, but rather, insightful information ...
(Date:12/25/2018)... ... 2018 , ... Researchers at the Icahn School of Medicine ... a long-standing computational concept known as “blacklisting,” which is commonly employed as a ... as a filter to single out genetic variations in patient genomes and exomes ...
Breaking Biology News(10 mins):
(Date:1/8/2019)... ... January 08, 2019 , ... The American Society of ... were named by a selection committee made up of industry leaders identified by the ... Development grants are mentored awards created to support ASGCT members designing transformative pilot studies ...
(Date:1/4/2019)... (PRWEB) , ... January 01, 2019 , ... ... first Microbiome Conference at the World Economic Forum Annual Meeting January 22-25, 2019 ... conference is invitation-only. , The World Economic Forum Annual Meeting brings together leaders ...
(Date:12/20/2018)... ... ... New Year’s brings reflection and desire to improve for individuals and businesses ... on the horizon, Jim Kasic, president and CEO of Boulder iQ, suggests five resolutions ... Regulation (MDR), digital health, and big data are just a few of the challenges ...
(Date:12/18/2018)... ... December 17, 2018 , ... ABCT , ... biosciences ventures invited to participate in the annual program. Twelve ventures will participate ... and a professional network. All startups receive an entrepreneur coach, access to active ...
Breaking Biology Technology:
Cached News: