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Genetic mutation, most common in Ashkenazi Jews, more than doubles cancer risk

er. We understand genes arent the whole story, said Gruber, an assistant professor of internal medicine in the U-M Medical School and an assistant professor of epidemiology in the U-M School of Public Health. Some people with a genetic susceptibility develop the disease, while others do not. Understanding the role of diet, physical activity, medications and other lifestyle factors will help us learn how to modify the risk of developing the disease.

While their results provide new insight into the complex causes of colorectal cancer, Rennert and Gruber stressed that it wont change how the disease is diagnosed or treated, until the results are confirmed by other scientists. However, the fact that our collaborators in New York independently came upon the same discovery in humans at almost exactly the same time is encouraging, said Gruber. It is also significant that University of Cincinnati researchers confirmed the same result in mice.

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Contact: Sally Pobojewski
pobo@umich.edu
734-615-6912
University of Michigan Health System
19-Sep-2002


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