HOME >> BIOLOGY >> NEWS
Genetic mutation linked to more aggressive breast cancer found more often in African-Americans

Alterations in a tumor suppressor gene called p53 are more prevalent in breast cancer of African-American women than white women, according to a new study. This study, published August 9, 2004 in the online edition of CANCER, a peer-reviewed journal of the American Cancer Society, "represents the first reported series of increased prevalence of p53 alterations in African-American breast cancer patients," according to an accompanying editorial. Free abstracts of the study and editorial will be available via Wiley InterScience (http://www.interscience.wiley.com/cancer-newsroom) upon embargo.

Ethnic differences in the incidence and mortality rates of breast cancer are noted in the United States and worldwide. In the U.S., the most apparent differences are seen between African-American and white women. African-American women have lower incidence rates of the disease, but have higher mortality rates. Moreover, African-American women present at a younger age and with more aggressive disease.

Explanations for these racial/ethnic differences have included socioeconomic factors, nutrition, medical comorbidities, and healthcare behavior. However, analyses demonstrate that higher mortality risk remains independent of these factors. Recent studies also show that tumors in African-Americans have significant different molecular characteristics on histopathology, such as lacking estrogen receptors.

Beth A. Jones, Ph.D., M.P.H., from Yale University School of Medicine and her colleagues studied the breast tumors of 145 African-American and 177 white women to further characterize the pattern of alterations of genes known to relate to tumor development and be associated with worse prognosis.

The authors found that African-American women were four times more likely than white women to show significant alterations in a tumor suppressor gene, p53. However, the prevalence of alterations in oth
'"/>

Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
9-Aug-2004


Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic differences might help distinguish thyroid cancers
3. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
4. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
5. Genetically modified bacterium as remedy for intestinal diseases
6. Genetic analysis rewrites salamanders evolutionary history
7. Genetic map of important tree genes outlined
8. Genetically-engineered marathon mouse keeps on running
9. Genetic clues found for common congenital brain disorder
10. Genetic discovery could dramatically reduce need for liver transplants in children
11. Genetic model for devastating form of paraplegia suggests new treatments

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... According to a new market research report "Consumer IAM Market by ... Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast to ... USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, at ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... 2017 No two people are believed ... New York University Tandon School of Engineering and ... that partial similarities between prints are common enough ... phones and other electronic devices can be more ... lies in the fact that fingerprint-based authentication systems ...
(Date:4/5/2017)... Allen Institute for Cell Science today announces the launch ... dynamic digital window into the human cell. The website ... deep learning to create predictive models of cell organization, ... suite of powerful tools. The Allen Cell Explorer will ... resources created and shared by the Allen Institute for ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... partners with the pharmaceutical and biotechnology industries to improve patient outcomes and quality ... Several trends in analytical testing are being attributed to new regulatory requirements for ...
(Date:10/11/2017)... ... 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for its 4th ... in San Francisco, CA. The Summit brings together current and former FDA office bearers, ... and government officials from around the world to address key issues in device compliance, ...
(Date:10/11/2017)... ... October 11, 2017 , ... A ... pregnancy rates in frozen and fresh in vitro fertilization (IVF) transfer ... age to IVF success. , After comparing the results from the fresh and ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder ... local San Diego Rotary Club. The event entitled “Stem Cells and ... had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: ...
Breaking Biology Technology:
Cached News: