HOME >> BIOLOGY >> NEWS
Genetic mutation linked to more aggressive breast cancer found more often in African-Americans

Alterations in a tumor suppressor gene called p53 are more prevalent in breast cancer of African-American women than white women, according to a new study. This study, published August 9, 2004 in the online edition of CANCER, a peer-reviewed journal of the American Cancer Society, "represents the first reported series of increased prevalence of p53 alterations in African-American breast cancer patients," according to an accompanying editorial. Free abstracts of the study and editorial will be available via Wiley InterScience (http://www.interscience.wiley.com/cancer-newsroom) upon embargo.

Ethnic differences in the incidence and mortality rates of breast cancer are noted in the United States and worldwide. In the U.S., the most apparent differences are seen between African-American and white women. African-American women have lower incidence rates of the disease, but have higher mortality rates. Moreover, African-American women present at a younger age and with more aggressive disease.

Explanations for these racial/ethnic differences have included socioeconomic factors, nutrition, medical comorbidities, and healthcare behavior. However, analyses demonstrate that higher mortality risk remains independent of these factors. Recent studies also show that tumors in African-Americans have significant different molecular characteristics on histopathology, such as lacking estrogen receptors.

Beth A. Jones, Ph.D., M.P.H., from Yale University School of Medicine and her colleagues studied the breast tumors of 145 African-American and 177 white women to further characterize the pattern of alterations of genes known to relate to tumor development and be associated with worse prognosis.

The authors found that African-American women were four times more likely than white women to show significant alterations in a tumor suppressor gene, p53. However, the prevalence of alterations in oth
'"/>

Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
9-Aug-2004


Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic differences might help distinguish thyroid cancers
3. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
4. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
5. Genetically modified bacterium as remedy for intestinal diseases
6. Genetic analysis rewrites salamanders evolutionary history
7. Genetic map of important tree genes outlined
8. Genetically-engineered marathon mouse keeps on running
9. Genetic clues found for common congenital brain disorder
10. Genetic discovery could dramatically reduce need for liver transplants in children
11. Genetic model for devastating form of paraplegia suggests new treatments

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2018)... (PRWEB) , ... August 06, 2018 , ... ... in front of The NCERC at Southern Illinois University Edwardsville’s University Park. SIUE ... also grain sorghum and sweet sorghum. These three feedstocks represent conventional biofuels production, ...
(Date:8/7/2018)... BOSTON and SOUTH JORDAN, Utah (PRWEB) , ... August 07, 2018 ... ... communications and collaboration solutions, announced today their new CT Cloud Voice and SIP solutions. ... cloud delivering a scalable and secure, quality voice solution that is far superior to ...
(Date:8/2/2018)... ... August 02, 2018 , ... RxS LLC (“RxS”), a ... today announced that Mark Jara, principal of the organization, has been named to ... industry. Individuals named to PharmaVOICE 100 are leaders who drive the industry forward ...
Breaking Biology News(10 mins):
(Date:7/25/2018)... ... July 25, 2018 , ... Almac Clinical Technologies ... supplies data through its flagship IXRS® 3 Interactive Response Technology (IRT) ... podcast features both Almac thought leaders and outside experts discussing best practices relating ...
(Date:7/24/2018)... OMAHA, Neb. (PRWEB) , ... July 23, 2018 ... ... the impact of a biofield energy treated nutraceutical to increase immunity and improve ... well as, immune function response assessed in the preclinical research were significantly reduced. ...
(Date:7/24/2018)... ... 24, 2018 , ... Boval was founded in 1978 when Mr. Douglas Northcott ... Boval’s early days most of the BSA manufactured was for blood banking reagents; however, ... after gel cards changed that market and displaced most of the large volume needs. ...
(Date:7/22/2018)... , ... July 19, 2018 , ... ... driven channel professional has joined their team. With more than ten years of ... Adam will deliver his expertise as CallTower’s Channel Director for the Southwest and ...
Breaking Biology Technology:
Cached News: