Genetic mutation linked to more aggressive breast cancer found more often in African...( er cancer-related genes HER-2/neu and...)

Genetic mutation linked to more aggressive breast cancer found more often in African-Americans

er cancer-related genes, HER-2/neu, and the previously unstudied, c-met, did not differ significantly across racial groups. Overall, the burden of poor prognostic factors was found to be greater among African-American women.

In an accompanying editorial, Lisa A. Newman, M.D., M.P.H., of the University of Michigan says the study is the first population-based study to demonstrate "a significant ethnic/race difference in p53 expression." Taken in the context of breast cancer, this study's novel use of molecular biology has opened "the door to improved understanding of ethnicity-related variation in breast cancer risk and outcome," writes Dr. Newman.

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Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
9-Aug-2004

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