HOME >> BIOLOGY >> NEWS
Genetic on-off switch found at Purdue could turn on gene therapy

WEST LAFAYETTE, Ind.--A Purdue University researcher studying genetic on-off switches in yeast found a system that could be useful in human gene therapy.

Gunter Kohlhaw, a recently retired Purdue biochemistry professor, envisions a time when gene therapy will alleviate suffering from diabetes mellitus, familial gout, hypercholesterolemia or any of the other 400-plus diseases caused by an underlying genetic deficiency. But in many cases, before gene therapy can work efficiently, doctors must find genetic switches to turn therapeutic genes on and off. Such switches let them regulate levels of compounds like insulin in diabetics.

Kohlhaw and his co-workers have found one switch that looks promising.

"We have a system that is in its infancy, but which conceivably could be useful in mammals," Kohlhaw says. "We know it works perfectly in cultured mouse cells."

Other on-off gene switches already exist, but they depend on hormones or the antibiotic tetracycline. People have to eat or get an injection of a hormone or antibiotic to turn the therapeutic genes on or off, and some people can't or don't want to risk side effects associated with those compounds.

Because the compounds that make up Kohlhaw's gene switch are natural components of yeast, they shouldn't affect human health, he says, although researchers need to test them to be sure. Both compounds are part of the yeast's system for producing leucine, an amino acid essential to human health.

"What's really unique about the system is that it's not present in humans, so it can be genetically engineered in human cells and completely controlled from the outside," says Michael Hampsey, a professor in the Department of Biochemistry at the University of Medicine and Dentistry of New Jersey. "It could be used in gene therapy and other systems where tight control over gene expression is critical."

The on-off switch discovered by Kohlhaw and his co-workers at Purdue consists of two m
'"/>

Contact: Rebecca J. Goetz
rjg@aes.purdue.edu
765-494-0461
Purdue University
12-Oct-1999


Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic differences might help distinguish thyroid cancers
3. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
4. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
5. Genetically modified bacterium as remedy for intestinal diseases
6. Genetic analysis rewrites salamanders evolutionary history
7. Genetic map of important tree genes outlined
8. Genetically-engineered marathon mouse keeps on running
9. Genetic clues found for common congenital brain disorder
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. Genetic discovery could dramatically reduce need for liver transplants in children

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... September 03, 2020 , ... Litmus Health ... extensive third-party assessment of the company’s security practices has been completed. The assessment ... regulations. The comprehensive evaluation reviewed Litmus’ processes and systems, assessing them to see ...
(Date:8/26/2020)... ... August 25, 2020 , ... ... in partnership with Essex Bio-Technology, a bio-pharmaceutical company specializing in Ophthalmology and ... study of SkQ1 ophthalmic solution in patients with moderate to severe Dry ...
(Date:8/26/2020)... ... August 25, 2020 , ... Modality Solutions, a ... 2020 annual Inc. 5000 list. The list is the most prestigious ranking of the ... well, and for this year’s list, reported three-year revenue growth of 71 percent. ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... ... , ... Join experts from Reed Tech , Gary Saner, Sr. Manager, ... hour live webinar on Thursday, August 13, 2020 at 11am EDT (4pm ... devices. Specifically, for medical devices, the NMPA has departments dealing with medical device registration ...
(Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to ... Bioactives. “It’s the only technology of its kind on the market and we were ... with the protective capacity of traditional cultured ingredients, creating a natural way to extend ...
(Date:7/18/2020)... , ... July 17, 2020 , ... ... consulting firm for the life sciences and food industries, is pleased to announce ... of Clinical Research – Business Development. , Charles is an accomplished and results-driven ...
(Date:7/10/2020)... ... July 09, 2020 , ... PathSensors ... (MIT) has expanded the company’s exclusive license to include clinical applications for ... diagnostic market, focusing initially on the SARS-CoV-2 biosensor. CANARY’s™ fast and ...
Breaking Biology Technology:
Cached News: