Genetic signature may predict recurrence in colon cancer patients

RARITAN, NJ, APRIL 29, 2004 A new prognostic marker has shown potential to predict recurrence in certain colon cancer patients, according to a study published in the May 1st issue of the Journal of Clinical Oncology.

In the study, a team of researchers led by Veridex, LLC, a Johnson & Johnson company, used gene expression profiling to identify the new marker a 23-gene signature which may predict disease recurrence in patients initially diagnosed with Dukes' B colon cancer.

The study marks the first significant application of genomics in searching for molecular markers for colon cancer prognosis and is also the subject of an editorial in the Journal.

While the standard of care for patients with Dukes' B, or Stage II, colon cancer surgical resection of the diseased tissue is considered highly effective, up to 20-30 percent of these patients can later develop recurrence and die from the disease. Patients classified as Dukes' B are thought to only have local disease, however, the incidence of relapse indicates existence of undetected disseminated disease and points to the need for more accurate methods for predicting recurrence.

"The key to increasing survival of these patients lies in the ability to accurately identify which of them is at high risk of relapse," says David Atkins, Ph.D., General Manager, Molecular Diagnostics for Veridex and principal investigator on the study. "The hypothesis that we're testing is that all of the information we need to characterize the disease can be found in the primary tumor."

The study involved the analysis of RNA samples from banked tumors from 74 Dukes' B colon cancer patients. Each sample was analyzed using several highly parallel methods for analysis of gene expression. Thirty-one of these patients developed tumor relapse in less than three years, while 43 patients remained disease-free for more than three years after surgery. Armed with this information, two approaches were u

Contact: Stephanie Hughes Koenig
Gabbe Group

Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic differences might help distinguish thyroid cancers
3. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
4. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
5. Genetically modified bacterium as remedy for intestinal diseases
6. Genetic analysis rewrites salamanders evolutionary history
7. Genetic map of important tree genes outlined
8. Genetically-engineered marathon mouse keeps on running
9. Genetic clues found for common congenital brain disorder
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. Genetic discovery could dramatically reduce need for liver transplants in children

Post Your Comments:

(Date:6/25/2020)... , ... June 24, 2020 , ... ... enterprise software and software-driven clinical data services that accelerate drug development, is collaborating ... selinexor, an XPO1 inhibitor, in hospitalized patients with severe COVID-19. This is the ...
(Date:6/23/2020)... (PRWEB) , ... June 23, 2020 , ... ... supporting sustainable healthcare, and Renovagen Ltd, a UK supplier and manufacturer of innovative ... to support testing operations in the fight against the COVID-19 pandemic in Zambia. ...
(Date:6/23/2020)... THE WOODLNDS, Texas (PRWEB) , ... June 23, ... ... in X-ray analytical instrumentation, is pleased to announce the next event in a ... of X-ray scattering. , The TOPIQ series of webinars was developed in response ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... , ... July 29, 2020 , ... ... can combine up to three different materials for use with CRM, neurostimulation, vascular, ... to three materials to meet specific design requirements, performance, and cost criteria; especially ...
(Date:7/31/2020)... ... 29, 2020 , ... eSource has long been touted as the solution to ... of eSource, the reasons it did not take off as quickly as people initially ... industry is moving towards capturing data electronically for clinical trials and then repurposing it ...
(Date:7/31/2020)... FRANCISCO (PRWEB) , ... July ... ... provider of cloud-based software for the life sciences industry, today announced the ... presentation platform designed specifically for Medical Science Liaisons (MSLs) and other field ...
(Date:7/18/2020)... , ... July 16, 2020 , ... After research model ... completion of a great surgery is only the beginning of a successful study, while ... community. , Join Brad Gien, Global Head of Surgery from Envigo in ...
Breaking Biology Technology:
Cached News: