HOME >> BIOLOGY >> NEWS
Genetic studies shed light on the malaria parasite's origins and drug resistance

Researchers at the National Institutes of Health (NIH) report mining the genome of the malaria parasite has uncovered new data showing the parasite is genetically more diverse and much older -- at least 100,000 years old -- than some scientists have thought. The new information suggests creating vaccines to control the deadly disease poses a greater challenge than some may have imagined.

In a second paper, the NIH-led group also found that parasites resistant to chloroquine, a former mainstay antimalaria drug, arose in several geographic locations and rapidly spread across continents. This finding upends the long-held notion of some scientists that chloroquine resistance developed independently in only two areas in the mid-20th century and slowly spread to other countries from those sites. The new information implies that resistance to chloroquine and other antimalaria drugs can arise and spread more pervasively than previously thought and argues for careful drug-use monitoring programs.

The new reports appear in back-to-back papers published in the July 18 issue of Nature.

Plasmodium falciparum, the parasite responsible for most deadly cases of malaria, thrives in the tropics and infects about 300 million people annually. One to 2 million people, mostly infants and children, die of the disease each year. The number of cases of malaria worldwide is increasing, mainly because of the evolution of drug-resistant parasites.

Debate regarding the genetic diversity and origin of the parasite has been ongoing since the late 1990s. It was then that a group of evolutionary biologists first proposed a "Malaria Eve" hypothesis to explain the origin of the parasite. By examining 10 genes of the malaria parasite, these scientists proposed that the bug is relatively young -- 3,000 to 5,000 years old -- and genetically similar from place to place, and as such, should not be too difficult to control.

To explore the question in mo
'"/>

Contact: Laurie K. Doepel
doepel@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
17-Jul-2002


Page: 1 2 3

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic differences might help distinguish thyroid cancers
3. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
4. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
5. Genetically modified bacterium as remedy for intestinal diseases
6. Genetic analysis rewrites salamanders evolutionary history
7. Genetic map of important tree genes outlined
8. Genetically-engineered marathon mouse keeps on running
9. Genetic clues found for common congenital brain disorder
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. Genetic discovery could dramatically reduce need for liver transplants in children

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2019)... ... January 31, 2019 , ... ... Morrisville, NC, providing full, customizable clinical research services across multiple therapeutic areas, ... programs for early stage life science entrepreneurs in the Research Triangle region ...
(Date:1/25/2019)... (PRWEB) , ... January 24, 2019 , ... ... the results of its 2019 Association Industry Survey. The report indicates membership growth ... email between mid-November to early December 2018, received responses from over 500 association ...
(Date:1/20/2019)... (PRWEB) , ... January 16, 2019 , ... As the ... offering through the introduction of its own liver 3D cell culture models. In an ... its models, protocols and validation criteria so that any researcher can replicate these models ...
Breaking Biology News(10 mins):
(Date:1/30/2019)... ... January 29, 2019 , ... K&R Negotiations announced today that Mladen Kresic, CEO ... event titled: Six Ways to Shorten the Sales Cycle : Reduce Complexity and ... the BrightTALK network. , Negotiation expert Kresic will discuss the realities of today’s ...
(Date:1/30/2019)... ... 30, 2019 , ... Through its Microbiome Grant Initiative ... study design, planning, sample collection, and analysis to a team of researchers at ... study the interactions between gut microbial composition and cardiovascular health risks, such as ...
(Date:1/24/2019)... ... January 22, 2019 , ... Controlled Contamination Services is pleased to announce three ... of these valuable new team members will support its growing operation across the US ... CCS scales its business. This addition will enable CCS to widen its reach and ...
(Date:1/24/2019)... SAN FRANCISCO (PRWEB) , ... January 23, 2019 ... ... the leader in microbial genomics, has awarded microbiome research support in study design, ... Indies (UWI), Faculty of Medical Sciences, St. Augustine Campus in Trinidad led by ...
Breaking Biology Technology:
Cached News: