HOME >> BIOLOGY >> NEWS
Genetic studies shed light on the malaria parasite's origins and drug resistance

Researchers at the National Institutes of Health (NIH) report mining the genome of the malaria parasite has uncovered new data showing the parasite is genetically more diverse and much older -- at least 100,000 years old -- than some scientists have thought. The new information suggests creating vaccines to control the deadly disease poses a greater challenge than some may have imagined.

In a second paper, the NIH-led group also found that parasites resistant to chloroquine, a former mainstay antimalaria drug, arose in several geographic locations and rapidly spread across continents. This finding upends the long-held notion of some scientists that chloroquine resistance developed independently in only two areas in the mid-20th century and slowly spread to other countries from those sites. The new information implies that resistance to chloroquine and other antimalaria drugs can arise and spread more pervasively than previously thought and argues for careful drug-use monitoring programs.

The new reports appear in back-to-back papers published in the July 18 issue of Nature.

Plasmodium falciparum, the parasite responsible for most deadly cases of malaria, thrives in the tropics and infects about 300 million people annually. One to 2 million people, mostly infants and children, die of the disease each year. The number of cases of malaria worldwide is increasing, mainly because of the evolution of drug-resistant parasites.

Debate regarding the genetic diversity and origin of the parasite has been ongoing since the late 1990s. It was then that a group of evolutionary biologists first proposed a "Malaria Eve" hypothesis to explain the origin of the parasite. By examining 10 genes of the malaria parasite, these scientists proposed that the bug is relatively young -- 3,000 to 5,000 years old -- and genetically similar from place to place, and as such, should not be too difficult to control.

To explore the question in mo
'"/>

Contact: Laurie K. Doepel
doepel@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
17-Jul-2002


Page: 1 2 3

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Genetic differences might help distinguish thyroid cancers
3. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
4. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
5. Genetically modified bacterium as remedy for intestinal diseases
6. Genetic analysis rewrites salamanders evolutionary history
7. Genetic map of important tree genes outlined
8. Genetically-engineered marathon mouse keeps on running
9. Genetic clues found for common congenital brain disorder
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. Genetic discovery could dramatically reduce need for liver transplants in children

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/12/2019)... ... ... Neal O’Farrell is one of the first generation of security and privacy ... the consumer advocacy non-profit the Identity Theft Council as well as Schooled in Security, ... Commission’s Cybersecurity Roundtable and is currently a fellow of the EP3 foundation. , “I ...
(Date:4/12/2019)... ... April 12, 2019 , ... Gnubiotics ... complex microbiota accessible carbohydrates (MACs) as specialty ingredients for the global animal and ... Register and commercial launch of its first-in class microbiome modulating prebiotic GNU100, for ...
(Date:4/9/2019)... ... ... The McLeod Center for Cancer Treatment and Research has been named ... by an independent, third-party panel of experts in radiation oncology, patient safety and treatment ... is the only such cancer center in South Carolina. The hospital also represents one ...
Breaking Biology News(10 mins):
(Date:4/4/2019)... , ... April 03, 2019 , ... ... through intimate off-the-record collaboration and dialogue, today announces its Boston CEO conference to ... insights into the industry’s challenges and opportunities with high-level panels and discussions from ...
(Date:3/23/2019)... ... March 22, 2019 , ... uBiome has awarded microbiome research ... researchers at Nnamdi Azikiwe University in Anambra State, Nigeria led by Dr. Kingsley ... Department of Medical Laboratory Sciences and Deputy Provost, College of Health Sciences. The ...
(Date:3/19/2019)... Calif. (PRWEB) , ... March 19, 2019 , ... ... Konica Minolta, Inc. (Konica Minolta) today announced the formation of their inaugural Scientific ... the advancement of precision medicine that takes into account individual variability in genes, ...
(Date:3/15/2019)... PAULO and ATLANTA (PRWEB) , ... ... ... completed the acquisition of 100% equity in American Process Inc. and affiliate ... include the Alpena Biorefinery in Alpena Michigan, the Thomaston Biorefinery and R&D ...
Breaking Biology Technology:
Cached News: