HOME >> BIOLOGY >> NEWS
Genetically Engineered Mice Exhibit Anxiety, Offering Insight Into Role Of Serotonin In Brain

Researchers led by a UC San Francisco investigator have genetically altered the serotonin brain system of mice, producing animals that exhibit anxiety, thereby offering an important new model for exploring the way in which the serotonin brain system contributes to anxiety in humans.

The model, reported in the December 7 issue of Proceedings of the National Academy of Science, could help researchers come up with more refined targets for psychiatric drugs. It also could serve as a model for examining inherited personality disorders involving anxiety, the researchers said. Overall, the model provides an important inroad for exploring the highly elaborate, inscrutable serotonin system, which regulates most, if not all, complex behaviors.

Serotonin is one of the brain's key neurotransmitters, which are signaling molecules that transmit chemical messages between brain cells, or neurons. The molecule communicates its messages through interactions with at least 14 distinct types of serotonin receptors, located on the surface of various types of nerve cells in the brain.

In most people, the neural system manages to maintain a normal balance of serotonin activity. In some, however, activity is either abnormally heightened or depressed in any number of different neural pathways. The type of impact serotonin has on the nervous system is determined by its success, or lack thereof, in reaching its target receptors, and the response that these receptors have to the neurotransmitter--either stimulating or inhibiting its activity.

While unusually elevated or inhibited serotonin activity has been implicated in many psychiatric disorders, scientists are unclear about the relative contribution of the various receptor subtypes to the regulation of particular behaviors. "It may be that the set of serotonin receptors regulating one type of behavior, such as feeding, differs from those controlling other responses, such as anxiety, depression and aggression," said the
'"/>

Contact: Jennifer O'Brien
jobrien@itsa.ucsf.edu
415-476-2557
University of California - San Francisco
7-Dec-1998


Page: 1 2 3 4

Related biology news :

1. Genetically modified bacterium as remedy for intestinal diseases
2. Genetically-engineered marathon mouse keeps on running
3. Purdue scientists: Genetically modified fish could damage ecology
4. Genetically modified E. coli produce plant product used in foods and cosmetics, Science study says
5. Genetically modified crops not necessarily a threat to the environment
6. Genetically modified mice provide information on treatments for cocaine dependence
7. Genetically engineered mice offer hope for isolating beta cells and treatment of type 2 diabetes
8. Genetically modified crops in India produced greater yields, reduced pesticide use, new study finds
9. Genetically modified crops may pass helpful traits to weeds, study finds
10. Genetically modified eggplants (aubergines) shown to be 30% more productive
11. Genetically modified crops -- what do scientists say?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... June 23, 2020 , ... Kemp ... announced that the company has received ISO9001:2015 certification for the development and ... industries. The decision to pursue ISO9001 accreditation demonstrates Kemp’s commitment to a ...
(Date:6/23/2020)... THE WOODLNDS, Texas (PRWEB) , ... June 23, ... ... in X-ray analytical instrumentation, is pleased to announce the next event in a ... of X-ray scattering. , The TOPIQ series of webinars was developed in response ...
(Date:6/19/2020)... ... June 18, 2020 , ... ... series, “Automate Your Lab with Software for Data Decisions,” for pharmaceutical and ... how to integrate and automate cutting-edge scientific instruments and laboratory equipment from ...
Breaking Biology News(10 mins):
(Date:6/2/2020)... ... June 01, 2020 , ... As part ... positive change in the world, enterprise security solutions provider bitsIO donated time to ... working from home during self-quarantines and shelter-in-place orders, companies are increasingly concerned about ...
(Date:5/28/2020)... ... 28, 2020 , ... Genedata, the leading provider of enterprise ... ® 17.0, the latest version of its enterprise software for the automated analysis, ... will host a webinar on June 10, 2020, detailing and demonstrating the features ...
(Date:5/21/2020)... ... May 21, 2020 , ... Threats to intellectual property, political ... Contrary to conventional wisdom that says the coronavirus pandemic will generally benefit biopharmaceutical ... from the pandemic commercially weaker, dealing with delays in new product launches and ...
(Date:5/21/2020)... Calif. (PRWEB) , ... May 20, 2020 , ... ... the addition of Simon Prakash, who will serve as the company’s executive vice ... at a time when Exo is disrupting the medical imaging space, bringing more ...
Breaking Biology Technology:
Cached News: