HOME >> BIOLOGY >> NEWS
Genetically Engineered Mice Show Characteristic Signs Of Alzheimer's, Could Be Ideal Tool For Testing New Therapies

out treatments to combat these detrimental effects."

The work was conducted by investigators at the Gladstone Institute of Neurological Disease, a major new research enterprise based at the San Francisco General Hospital campus of UCSF. The results are published in the Sept. 1 issue of Proceedings of the National Academy of Sciences U.S.A.

In one experiment, mice had to learn the location of a hidden target in a maze that tests their ability to remember and process spatial information. Similar skills are strongly affected in Alzheimer's patients, who often get lost because they have trouble finding their way home.

ApoE3 mice learned how to find the hidden target with relative ease, whereas their apoE4 counterparts had difficulty with the exercise, and some never found the target at all even after repeated tries. Consistent with the age dependence of Alzheimer's disease, only older apoE4 mice showed deficits in learning and memory, whereas young apoE4 mice were not impaired.

In another experiment, mice were placed in an open field inside a cage, and their movements were monitored with motion sensors. Older apoE4 mice showed much less exploratory curiosity in this test than age-matched apoE3 mice. The investigators speculate that these findings might also relate to Alzheimer's patients, who often lose interest in their environment and abandon activities that once engaged them.

In both experiments, the researchers noticed a distinct difference in behavior between female and male mice, with the females experiencing a higher level of impairment. These results are consistent with clinical studies by other investigators which suggest that apoE4 increases Alzheimer's risk and decreases responsiveness to treatments more strongly in women than in men.

The researchers already have begun to manipulate the levels of apoE4 in the brains of these mice to see what impact these changes might have on their behavior. Mucke said
'"/>

Contact: Corinna Kaarlela
corinna@itsa.ucsf.edu
(415) 476-3804
University of California - San Francisco
31-Aug-1998


Page: 1 2 3

Related biology news :

1. Genetically modified bacterium as remedy for intestinal diseases
2. Genetically-engineered marathon mouse keeps on running
3. Purdue scientists: Genetically modified fish could damage ecology
4. Genetically modified E. coli produce plant product used in foods and cosmetics, Science study says
5. Genetically modified crops not necessarily a threat to the environment
6. Genetically modified mice provide information on treatments for cocaine dependence
7. Genetically engineered mice offer hope for isolating beta cells and treatment of type 2 diabetes
8. Genetically modified crops in India produced greater yields, reduced pesticide use, new study finds
9. Genetically modified crops may pass helpful traits to weeds, study finds
10. Genetically modified eggplants (aubergines) shown to be 30% more productive
11. Genetically modified crops -- what do scientists say?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2016)... --  MedNet Solutions , an innovative SaaS-based eClinical technology ... is pleased to announce the attainment of record-setting corporate ... of the company,s laser focus on (and growing international ... comprehensive, easy-to-use and highly affordable cloud-based technology platform. ... growth achievements in 2015 include: , Record ...
(Date:1/18/2016)... JOSE, Calif. , Jan. 18, 2016 /PRNewswire/ ... security software that simplifies the use and access ... technology and go-to-market partnership with American Cyber.  ... Cyber brings extensive experience leading transformational C4ISR and ... implementing and integrating the latest proven technology solutions," ...
(Date:1/13/2016)... , January 13, 2016 ... published a new market report titled - Biometric Sensors Market ... Forecast, 2015 - 2023. According to the report, the global biometric ... is anticipated to reach US$1,625.8 mn by 2023, expanding ... In terms of volume, the biometric sensors market is ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... DUBLIN , Feb. 10, 2016  Allergan plc ... today announced that Brent Saunders , Allergan,s CEO ... in a fireside chat session at the RBC Capital ... 12:30 p.m. ET at The New York Palace Hotel ... presentation will be webcast live and can be accessed ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... Society of Pharmaceutical Engineering (ISPE) Rocky Mountain Chapter 21st Annual Vendor Exhibition on ... fill more than 100 tables for its annual event, which will run from ...
(Date:2/10/2016)... CA (PRWEB) , ... February 10, 2016 , ... ... Multiplex Testing (PROMPT), a research registry built on the secure online PatientCrossroads platform, ... 2014. More than 1,600 participants have joined the PROMPT study, which seeks to ...
(Date:2/10/2016)... Jolla CA (PRWEB) , ... February 10, 2016 , ... ... new agents for the treatment of Alzheimer’s disease, announced today it has been selected ... February 18th at the Breakers in Palm Beach, Florida. The purpose of the ...
Breaking Biology Technology:
Cached News: