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Genetically Engineered Mice Show Characteristic Signs Of Alzheimer's, Could Be Ideal Tool For Testing New Therapies

it may be possible to design drugs that inhibit apoE4 or simulate apoE3 to counteract the neurological effects of Alzheimer's. "The real test of this model will come when we can test treatment strategies and see if they will work in humans," he said.

In addition to Mucke and Raber, the researchers on the study, all of the Gladstone Institutes, included Derek Wong, research associate; postdoctoral fellows Manuel Buttini, PhD, Matthias Orth, MD, PhD, and Stefano Bellosta, PhD; Robert E. Pitas, PhD, UCSF professor of pathology and Gladstone senior investigator; and Robert W. Mahley, MD, PhD, UCSF professor of pathology and medicine and president of the Gladstone Institutes. The research was supported by the Gladstone Institutes and Cambridge Neuroscience in Cambridge, Mass.


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Contact: Corinna Kaarlela
corinna@itsa.ucsf.edu
(415) 476-3804
University of California - San Francisco
31-Aug-1998


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