HOME >> BIOLOGY >> NEWS
Genetically-engineered 'marathon mouse' keeps on running

By enhancing the function of a single protein, Howard Hughes Medical Institute researchers have produced a "marathon mouse" with altered muscle composition and enough physical endurance to run twice as far as normal mice. Mice with the enhanced protein also showed an innate resistance to weight gain, even when fed a high-fat diet that caused normal mice to become obese.

According to the researchers, their finding will offer important insights into the machinery that powers muscle development and the physiological changes produced by exercise. The finding also suggests a route to designing drugs that enhance muscle development and mimic all the benefits of exercise. The researchers said such drugs could aid patients whose debilitating diseases prevent them from exercising. The researchers recognize that such drugs already being tested by pharmaceutical companies could be abused as a way to enhance athletic performance.

Led by Howard Hughes Medical Institute investigator Ronald M. Evans at The Salk Institute, the researchers published their findings online August 24, 2004, in the journal Public Library of Science Biology. Other co-authors are from Seoul National University in Korea.

In their studies, the researchers were exploring the effects of altering the gene for a protein called PPAR-delta -- a master regulator of numerous genes -- to enhance that protein's activity. According to Evans, they had not expected the profound and far-reaching physiological effects of this single genetic alteration.

"In previous work, we had shown that in various tissues, particularly adipose tissues, activating PPAR-delta increased fat burning and, as a result, decreased fat-tissue mass," said Evans. "Going into this experiment, the possibility of an effect on muscle fibers was not on our radar screen."

However, when the researchers produced mice with enhanced PPAR-delta activity, they saw a major transformation in skeletal muscle fibers. The mic
'"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
23-Aug-2004


Page: 1 2 3 4

Related biology news :

1. Mighty mouse gene works the same way in people
2. Coordinating power of circadian rhythms keeps estrus and pregnancy on track
3. A gene that keeps species apart
4. Protein keeps cold fish from becoming frozen flounder, new study shows
5. An apple a day keeps the doctor away . . . but so may a cigarette
6. An aspirin a day keeps Staphylococcus aureus away
7. Protein discovered that keeps hemoglobin in balance
8. What keeps the nervous system intact?
9. Cannibalism in the North Atlantic: Scripps researcher finds crustacean species keeps population in check by eating its young
10. Scientists determine how chemistry keeps weird worms "out of hot water" at steaming deep-sea vents
11. Talking device keeps HIV patients on the straight and narrow

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2018)... (PRWEB) , ... August 07, 2018 , ... CallTower ... today their new CT Cloud Voice and SIP solutions. CT Cloud solutions are ... secure, quality voice solution that is far superior to traditional PBX systems, at a ...
(Date:8/1/2018)... ... August 01, 2018 , ... Dr. Asher Kimchi, Founder ... winning recipients of the 2018 IAC Awards at the 23rd World Congress on Heart ... also named four faculty to receive the Distinguished Fellowship Awards. , Dr. Asher Kimchi, ...
(Date:8/1/2018)... , ... August 01, 2018 , ... Visikol CEO Dr. ... services and strong pharmaceutical company partnerships that Visikol will far exceed its original 2018 ... developing its suite of digital pathology tools, whole mount imaging ...
Breaking Biology News(10 mins):
(Date:8/9/2018)... ... August 08, 2018 , ... ... was developed and is continually updated by a talented scientific team that includes ... service provides: , 1. Information on the medical impact of a patient’s ...
(Date:8/9/2018)... ... August 09, 2018 , ... Simpson ... construction (AEC) experts with building owners and managers for a full-day discussion on ... Construct symposium comes to Boston for the first time on Thursday, 13 September ...
(Date:7/31/2018)... (PRWEB) , ... July 31, 2018 , ... ... 2 additional CE/IVD marked molecular quality controls to its expanding CE/IVD product inventory. ... controls to our expanding CE/IVD QC offerings. ZeptoMetrix remains entirely committed to fully ...
(Date:7/25/2018)... ... July 25, 2018 , ... Dimitrius Anagnos, an evidence-based ... combat inflammation and autoimmune disorders. , The preclinical research assessed biomarkers for ... was reported:, Over 70% decrease in Interleukin (IL-1ß) ...
Breaking Biology Technology:
Cached News: