HOME >> BIOLOGY >> NEWS
Genetically-engineered 'marathon mouse' keeps on running

By enhancing the function of a single protein, Howard Hughes Medical Institute researchers have produced a "marathon mouse" with altered muscle composition and enough physical endurance to run twice as far as normal mice. Mice with the enhanced protein also showed an innate resistance to weight gain, even when fed a high-fat diet that caused normal mice to become obese.

According to the researchers, their finding will offer important insights into the machinery that powers muscle development and the physiological changes produced by exercise. The finding also suggests a route to designing drugs that enhance muscle development and mimic all the benefits of exercise. The researchers said such drugs could aid patients whose debilitating diseases prevent them from exercising. The researchers recognize that such drugs already being tested by pharmaceutical companies could be abused as a way to enhance athletic performance.

Led by Howard Hughes Medical Institute investigator Ronald M. Evans at The Salk Institute, the researchers published their findings online August 24, 2004, in the journal Public Library of Science Biology. Other co-authors are from Seoul National University in Korea.

In their studies, the researchers were exploring the effects of altering the gene for a protein called PPAR-delta -- a master regulator of numerous genes -- to enhance that protein's activity. According to Evans, they had not expected the profound and far-reaching physiological effects of this single genetic alteration.

"In previous work, we had shown that in various tissues, particularly adipose tissues, activating PPAR-delta increased fat burning and, as a result, decreased fat-tissue mass," said Evans. "Going into this experiment, the possibility of an effect on muscle fibers was not on our radar screen."

However, when the researchers produced mice with enhanced PPAR-delta activity, they saw a major transformation in skeletal muscle fibers. The mic
'"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
23-Aug-2004


Page: 1 2 3 4

Related biology news :

1. Mighty mouse gene works the same way in people
2. Coordinating power of circadian rhythms keeps estrus and pregnancy on track
3. A gene that keeps species apart
4. Protein keeps cold fish from becoming frozen flounder, new study shows
5. An apple a day keeps the doctor away . . . but so may a cigarette
6. An aspirin a day keeps Staphylococcus aureus away
7. Protein discovered that keeps hemoglobin in balance
8. What keeps the nervous system intact?
9. Cannibalism in the North Atlantic: Scripps researcher finds crustacean species keeps population in check by eating its young
10. Scientists determine how chemistry keeps weird worms "out of hot water" at steaming deep-sea vents
11. Talking device keeps HIV patients on the straight and narrow

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/1/2020)... , ... April 30, 2020 , ... ... announced an alliance with Corritori Consulting Inc., a biopharmaceutical and regulatory services advisor. ... and companion diagnostics industries. Flagship and Corritori are taking a collaborative approach to ...
(Date:5/1/2020)... ... , ... More than 600 people undergo genetic counseling and testing each year ... by two genetic counselors. , My Gene Counsel , a digital health company ... High Rick Program to ensure that UConn’s patients who have undergone genetic testing for ...
(Date:4/30/2020)... ... April 28, 2020 , ... ... Lachman Consultants latest effort in providing timely and critical information to life science ... social distancing and health safety concerns. , “Providing the most up-to-date actionable guidance ...
Breaking Biology News(10 mins):
(Date:5/28/2020)... ... May 28, 2020 , ... ... the release of Genedata Screener ® 17.0, the latest version of its ... all in-vitro screening assay technologies. Genedata will host a webinar on June 10, ...
(Date:5/21/2020)... ... ... Experienced periodontist in Eden Prairie, MN, Dr. Andres Sanchez, offers a virtually ... technology. PIEZOSURGERY uses ultrasonic vibrations to gently cut bone in the mouth without ... especially when the implants need to be placed in a sensitive area of the ...
(Date:5/15/2020)... ... May 14, 2020 , ... Children with ... heart surgeries before becoming adults. The reason: there are no heart valve ... unmet need, the Department of Defense has awarded Draper, Boston Children’s Hospital and ...
(Date:5/14/2020)... ... May 12, 2020 , ... ... research, is bringing together thousands of industry leaders, clinicians, research scientists, medical professionals ... plenary speakers, Carl June, MD, Director of the Center for Cellular Immunotherapies at ...
Breaking Biology Technology:
Cached News: