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Genetically modified bacterium as remedy for intestinal diseases

nbroucke and his VIB colleagues, under the direction of Pieter Rottiers and Erik Remaut, took the earlier research further and placed the mouse gene with the code for mouse 'trefoil factors' (TFF) into the Lactococcus. TFF play an important role in the protection and healing of the epithelium - the inner wall - of the stomach- intestinal system. They also play a role in the construction of the stomach-intestinal tract. This structural function ensures that TFF never arrives in the intestine through oral administration, because along the way it attaches itself somewhere in the stomach-intestinal tract. This was also demonstrated in the tests on mice with acute enteritis: oral administration of TFF had no effect, but rectal administration did. Still, neither of the two methods of administration could match the impressive recovery of the mice following oral administration of the TFF bacteria.

The researchers also used the TFF bacteria to treat mice with chronic enteritis, which proved to be successful as well. This research confirms the findings from the earlier VIB research (under the direction of Lothar Steidler and Erik Remaut) concerning the therapeutic action of IL-10 bacteria. Thus, this method of working with genetically modified bacteria offers promising prospects for the treatment of both acute and chronic intestinal inflammation, and it can potentially be extended to other therapeutics as well.


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Contact: Sooike Stoops
sooike.stoops@vib.be
32-92-44-66-11
VIB, Flanders Interuniversity Institute of Biotechnology
14-Sep-2004


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