HOME >> BIOLOGY >> NEWS
Genetically modified mice provide information on treatments for cocaine dependence

Drug abuse places a tremendous burden on our nation each year, both in terms of crime, law enforcement demands, lost productivity, added costs of health care delivery, and premature death. Among those drugs that are abused, cocaine is considered one of the most powerful. Yet no effective medications exist to treat cocaine abuse, dependence or withdrawal.

In order to develop these needed medications, a better understanding of cocaine's brain mechanisms is required. Although it is known that cocaine acts on at least three different transporter systems -- the dopamine transporter, the serotonin transporter and the norepinephrine transporter -- it is not clear which combination of transporter systems holds the most potential as targets for developing treatments for cocaine abuse.

Recently, a collaborative research effort led by scientists at the University of North Carolina/Chapel Hill and Duke University used genetically-modified mice to provide information about the mediation of cocaine's rewarding effects. These findings promise to guide the development of potential medications for cocaine abuse. Drs. L.A. Dykstra, L.M. Bohn, R.M. Rodriguiz, W.C. Wetsel, R.R. Gainetdinov and M. G. Caron. University of North Carolina at Chapel Hill, Duke University, and Howard Hughes Medical Institute, presented their results at an American Society for Pharmacology & Experimental Therapeutics session at the Experimental Biology 2003 meeting in San Diego. In these studies, mice were genetically altered so they lacked two of the potential mediators of cocaine's effects. One of those mediators was the dopamine transporter, which is considered to be the primary site of cocaine's rewarding effects. The other mediator was the norepinephrine transporter.

Cocaine's rewarding effects were still apparent in mice that were lacking both the dopamine and the norepinephrine transporter. Indeed, cocaine was just as rewarding in mice lacking these targets as in control mice
'"/>

Contact: Sarah Goodwin
eb3press@bellsouth.net
770-270-0989
Federation of American Societies for Experimental Biology
12-Apr-2003


Page: 1 2

Related biology news :

1. Genetically modified bacterium as remedy for intestinal diseases
2. Genetically-engineered marathon mouse keeps on running
3. Purdue scientists: Genetically modified fish could damage ecology
4. Genetically modified E. coli produce plant product used in foods and cosmetics, Science study says
5. Genetically modified crops not necessarily a threat to the environment
6. Genetically engineered mice offer hope for isolating beta cells and treatment of type 2 diabetes
7. Genetically modified crops in India produced greater yields, reduced pesticide use, new study finds
8. Genetically modified crops may pass helpful traits to weeds, study finds
9. Genetically modified eggplants (aubergines) shown to be 30% more productive
10. Genetically modified crops -- what do scientists say?
11. Genetically engineered tomato plant grows in salty water

Post Your Comments:
(Date:8/19/2014)... have devised a new implantable tissue scaffold coated with ... few weeks. When applied to bone injuries or defects, ... new bone that looks and behaves just like the ... offer a dramatic improvement over the current standard for ... part of the patient,s body a painful process ...
(Date:8/19/2014)... infants born with neonatal abstinence syndrome (NAS) secondary ... time going through withdrawal than others, but the ... and epigenetic (when genes are turned on or ... factors, researchers at Boston University School of Medicine ... first of its kind study to identify some ...
(Date:8/19/2014)... seas during warm phases and became extinct during cold ... a link between marine crocodilian diversity and the evolution ... 140 million years. , The research, led by ... and formerly from the University of Bristol, UK is ... crocodiles are ,cold-blooded, animals that mainly live in fresh ...
Breaking Biology News(10 mins):Engineering new bone growth 2Engineering new bone growth 3In-utero methadone, Subutex exposure could alter gene expression, cause severe Neonatal Abstience Syndrome 2Evolution of marine crocodilians constrained by ocean temperatures 2
(Date:8/19/2014)... 2014 Cellgen Diagnostics ... to fund a corporate lab for its genetic-based ... development is a critical component in the move ... the implementation of personalized medicine – a more ... , Indiegogo contributions will support Cellgen’s intent to ...
(Date:8/19/2014)... , Aug. 19, 2014 ... the addition of the "Spectroscopy Equipment ... report to their offering. ... for Spectroscopy Equipment and Accessories in US$ ... Spectroscopy (UV-Vis spectrophotometers, Raman Spectrometers, NMR-EPR Spectrometers, ...
(Date:8/19/2014)... 2014 /PRNewswire/ - iCo Therapeutics Inc. ("iCo" or "the ... of its Oral Amphotericin B (Oral Amp B) ... conducted by ImmuneCarta®, the immune monitoring business unit ... of Oral Amp B in reactivating latent HIV ... intensive treatment with antiretroviral therapy. ...
(Date:8/18/2014)... /PRNewswire/ - SQI Diagnostics Inc. (TSX-V: SQD), a life sciences ... for advanced microarray diagnostics, today announced it will hold ... 2:00 pm ET.  During the call, ... review of SQI,s recent commercialization progress and then introduce ... recently appointed to the Board of Directors of SQI ...
Breaking Biology Technology:Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3Global Spectroscopy Equipment and Accessories - Strategic Business Report 2014 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 3SQI Diagnostics Announces Investor Conference Call with Dr. Allan Pronovost 2SQI Diagnostics Announces Investor Conference Call with Dr. Allan Pronovost 3
Cached News: