HOME >> BIOLOGY >> NEWS
Genetically modified mice provide information on treatments for cocaine dependence

Drug abuse places a tremendous burden on our nation each year, both in terms of crime, law enforcement demands, lost productivity, added costs of health care delivery, and premature death. Among those drugs that are abused, cocaine is considered one of the most powerful. Yet no effective medications exist to treat cocaine abuse, dependence or withdrawal.

In order to develop these needed medications, a better understanding of cocaine's brain mechanisms is required. Although it is known that cocaine acts on at least three different transporter systems -- the dopamine transporter, the serotonin transporter and the norepinephrine transporter -- it is not clear which combination of transporter systems holds the most potential as targets for developing treatments for cocaine abuse.

Recently, a collaborative research effort led by scientists at the University of North Carolina/Chapel Hill and Duke University used genetically-modified mice to provide information about the mediation of cocaine's rewarding effects. These findings promise to guide the development of potential medications for cocaine abuse. Drs. L.A. Dykstra, L.M. Bohn, R.M. Rodriguiz, W.C. Wetsel, R.R. Gainetdinov and M. G. Caron. University of North Carolina at Chapel Hill, Duke University, and Howard Hughes Medical Institute, presented their results at an American Society for Pharmacology & Experimental Therapeutics session at the Experimental Biology 2003 meeting in San Diego. In these studies, mice were genetically altered so they lacked two of the potential mediators of cocaine's effects. One of those mediators was the dopamine transporter, which is considered to be the primary site of cocaine's rewarding effects. The other mediator was the norepinephrine transporter.

Cocaine's rewarding effects were still apparent in mice that were lacking both the dopamine and the norepinephrine transporter. Indeed, cocaine was just as rewarding in mice lacking these targets as in control mice
'"/>

Contact: Sarah Goodwin
eb3press@bellsouth.net
770-270-0989
Federation of American Societies for Experimental Biology
12-Apr-2003


Page: 1 2

Related biology news :

1. Genetically modified bacterium as remedy for intestinal diseases
2. Genetically-engineered marathon mouse keeps on running
3. Purdue scientists: Genetically modified fish could damage ecology
4. Genetically modified E. coli produce plant product used in foods and cosmetics, Science study says
5. Genetically modified crops not necessarily a threat to the environment
6. Genetically engineered mice offer hope for isolating beta cells and treatment of type 2 diabetes
7. Genetically modified crops in India produced greater yields, reduced pesticide use, new study finds
8. Genetically modified crops may pass helpful traits to weeds, study finds
9. Genetically modified eggplants (aubergines) shown to be 30% more productive
10. Genetically modified crops -- what do scientists say?
11. Genetically engineered tomato plant grows in salty water

Post Your Comments:
(Date:5/22/2015)... -- According to a new market research ... Emotion, Forensic), by Software (Middleware, Databases), by Hardware (Cameras, Integrated ... Home) - Global Forecast to 2020", published by MarketsandMarkets, ... 2015 to $6.19 Billion by 2020, at a CAGR ... Tables and   43 Figures spread through 140 Pages ...
(Date:5/21/2015)... , May 21, 2015 The Sync ... of music for health, today announced a collaborative partnership ... The partnership will center on collaboration on original research, ... first step in the collaboration, The Sync Project and ... "Music as Medicine" in the 2015-2016 academic year.  ...
(Date:5/20/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... 3D-ID LLC, a company engaged in biometric identification is ... technology portion of the recently awarded TIES (Technical Information ... the Army. 3D-ID LLC has a suite ... enforcement and security agencies. Gino Pereira ...
Breaking Biology News(10 mins):Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3
(Date:5/28/2015)... 28, 2015 BioNorth Texas (BioNorthTX), ... representing the life sciences industry in northern region ... meeting at The Foundry in Dallas on April ... brought together a broad spectrum of biotech professionals ... organization's early successes in partnering with key life ...
(Date:5/28/2015)... Mass. , May 28, 2015 RXi ... focused on discovering and developing innovative therapeutics, primarily in ... pricing of a public offering of 26 million units ... share for gross proceeds of approximately $10.4 million. Each ... (ii) a 13-month overallotment purchase right to purchase 0.50 ...
(Date:5/28/2015)... Md. , May 28, 2015  GenVec, Inc. ... and CEO, Douglas J. Swirsky , will present ... Conference at 11 a.m. EDT on Thursday, June 4, ... of Mr. Swirsky,s presentation will be available at the ... be available on GenVec,s website.  To access, visit ...
(Date:5/28/2015)... 28, 2015 The Fertility Centers of ... Dr. Danielle Vitiello has taken on a new and ... Vitiello will provide guidance, leadership, oversight and quality assurance ... Dr. Vitiello among our team of experienced reproductive endocrinologists,” ... Joseph A. Hill, M.D. “Her expertise and compassionate, individualized ...
Breaking Biology Technology:BioNorthTX Holds Inaugural Board of Directors Meeting 2BioNorthTX Holds Inaugural Board of Directors Meeting 3RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 3GenVec To Present At The Jefferies Healthcare Conference 2Danielle Vitiello, MD of Fertility Centers of New England, Named New Medical Director 2
Cached News: