Citation source: Molecular Psychiatry 2003 Volume 8, number 1, pages 14-18.

For further information on this work, please contact Anthony (Tony) Payton, Centre for Integrated Genomic Medical Research, Stopford Building, Manchester University, Oxford Road, Manchester M13 9PT, UK. Phone: 44-161-275-7312. E-mail: tony@fs1.ser.man.ac.uk

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ARTICLE 2: "Role of the cholinergic muscarinic 2 receptor (CHRM2) gene in cognition."

D E Comings (1), S Wu (1), M Rostamkhani (1), M McGue (2), W G lacono (2), L S-C Cheng (4) and J P MacMurray (3)

(1) Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA

(2) Department of Psychology, University of Minnesta, Minneapolis, MN, USA

(3) Department of Genomics, MGI Applied Genomics, Long Beach, CA, USA

(4) Department of Biostatistics, City of Hope Medical Center, Duarte, CA 91010, USA

Cholinergic pathways have been widely implicated in cognition and memory, making the respective genes excellent candidate markers for cognitive abilities. Identification of a possible role of cholinergic receptor genes in humans has been hampered by the lack of reported polymorphisms. The authors identified a common AT 1890 polymorphism in the 3'UTR of the CHRM2 gene. To determine if it was associated with IQ, the authors examined 358 adult males and 470 adult females for a total of 828 adults. The subjects were the parents of twins from the Minnesota Twin and Family Study, a long-term study of the genetics and environmental factors in substance abuse. All subjects in the CHRM2 study were of Caucasian ancestry. All were given the Wechsler Adult Intelligence Scale-Revised (Vocabulary, Information, Block Design, and Picture Arrangement) test. The study was approved by the internal review boards of both the Unive
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Molecular Psychiatry
13-Feb-2003