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Genome researcher analyze chromosome 7

his colleagues identified approximately 1,150 protein-coding genes on chromosome 7, about 20 percent less than the 1,455 predicted in a previous study by a different team.

The accuracy and completeness of the human chromosome 7 sequence assembled by the International Human Genome Sequencing Consortium was evaluated in part by Eric D. Green, M.D., Ph.D., and his colleagues at NHGRI's Genome Technology Branch. When they compared the representation of markers called sequence-tagged sites (STSs) in the recently assembled sequence with STSs in previously constructed physical and genetic maps of chromosome 7, the NHGRI researchers found an excellent overall concordance.

Dr. Green, who is NHGRI's scientific director and a co-author of the study, also emphasized the value of comparing the sequence of human chromosome 7 to its recently sequenced counterpart in the mouse. "Comparing the human sequence to the mouse sequence allowed our team to perform much more rigorous analyses of genes than would have otherwise been possible. The ability to place the human sequence alongside the mouse sequence helped us to swiftly distinguish real, protein-coding genes from pseudo-genes. The power of comparative genomics really sharpened our focus," Dr. Green said.

In addition to NHGRI and Washington University, other institutions taking part in the chromosome 7 analysis were: University of Washington Genome Center, Seattle; University of California, Santa Cruz; Case Western Reserve University School of Medicine, Cleveland; and EMBL, Heidelberg, Germany.

There are 23 pairs of chromosomes in the human genome, which bear the 3 billion DNA letters that carry the genetic blueprint for human life. Chromosome 7 is one of the larger chromosomes, containing about 5 percent of the DNA in the human genome.

The sequencing work on chromosome 7 was carried out at the Genome Sequencing Center at the Washington University School of Medicine as part of the Human Ge
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Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
9-Jul-2003


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