HOME >> BIOLOGY >> NEWS
Genome-wide screen reveals new tricks of old genes

Johns Hopkins scientists have successfully used new techniques to search the yeast genome for genes that help keep copied chromosomes together, protecting the integrity of the organism's genetic material during cell division.

By combining two genome-wide screens, the researchers were able to narrow down the dozens of genes identified by the first screen to just 17 that made both cut-offs -- a number small enough to be cost- and time-efficient to consider in some detail. Their report appears in the April issue of Molecular Biology of the Cell.

"Data created from new genome-scanning techniques can be overwhelming. Reading all there is to know about 50 genes to figure out what new knowledge may be lurking in the haystack is very difficult," says Forrest Spencer, Ph.D., associate professor in Hopkins' McKusick-Nathans Institute of Genetic Medicine. "But by overlapping information from two screens, we were able to figure out what Mother Nature was trying to tell us that wasn't too complicated for us to understand."

While the researchers had hoped their screens would reveal new genes and their functions, they instead identified genes previously linked to two other aspects of shepherding genetic material during cell division. Fifteen of the highlighted genes were already known to help ensure the accuracy of copied DNA and two help move chromosomes to opposite ends of the dividing cell.

But the researchers' results give these "old" genes new jobs, associating them with cohesion, the little-understood process of keeping a chromosome and its copy together until the cell is ready to split in two. If the "sister" chromosomes aren't kept together, both copies could end up on one side of the dividing cell. Another problem is that the copies could undergo extra rearrangements, risking loss of important genes.

"If there's no cohesion, the cell will die," says Spencer. "However, if the process sometimes works and sometimes doesn't, some c
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
22-Apr-2004


Page: 1 2 3

Related biology news :

1. Study: Genome-wide scanning unravels complex birth defect
2. March of Dimes statement on newborn screening report
3. Virus known for its photo ops makes its movie screen debut
4. Only 21 states offer newborn screening tests recommended by March of Dimes
5. New screening method turns up potential compound for treating anthrax
6. Gene-based screen sorts cancer cases, say Stanford researchers
7. Genetic screening study at Stanford IDs most aggressive adult leukemia strains
8. New, non-radioactive screen for antimalarial compounds
9. Genetic screening recommended to detect new neurodegenerative disorder in men over age 50
10. HPV testing could be future strategy for primary screening for cervical cancer
11. Newborn screening for certain genetic disorders has benefits and some drawbacks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/5/2020)... ... March 05, 2020 , ... ... Board (SAB) comprised of the industry’s key opinion leaders and distinguished research ... private industry. Cytonus is a leading cell-based platform technology company focused on ...
(Date:3/5/2020)... ... March 05, 2020 , ... Diagenode, a ... MGI Tech (MGI), a subsidiary of global genomics leader BGI Group, today announced ... United States, Europe and Asia Pacific. , Under the terms of the ...
(Date:3/4/2020)... ... March 04, 2020 , ... ... announced the release of a unique, multi-dimensional nutraceutical formula for ocular blue light ... and natural plant biology to increase the retina’s healthy pigmentation and improve the ...
Breaking Biology News(10 mins):
(Date:2/21/2020)... ... ... Join Forrest Brown, Engineering Services Manager – Northeast Region and Jarred Christofaro, Engineering ... session on Wednesday, February 26, 2020 at 1pm EST to learn about:, ... add manufacturing flexibility in the future, especially for CMOs , C&Q Strategy ...
(Date:2/19/2020)... ... February 18, 2020 , ... ... today announced the launch of a new and unified global brand identity, as ... industry’s most complex engineering challenges, as well as an enthusiasm for designing and ...
(Date:2/11/2020)... ... February 11, 2020 , ... ... successful results from a long-term follow-up clinical study of outpatient L4-L5 lumbar ... (INSPAN LLC). Unlike extension block design, the Inspan device fixates the spine ...
(Date:2/5/2020)... (PRWEB) , ... February 04, 2020 , ... ... tools for characterizing microbiome populations down to the strain level, has announced a ... sell Shoreline Biome’s microbiome kits and other products to companies and research organizations ...
Breaking Biology Technology:
Cached News: