HOME >> BIOLOGY >> NEWS
Genome-wide screen reveals new tricks of old genes

Johns Hopkins scientists have successfully used new techniques to search the yeast genome for genes that help keep copied chromosomes together, protecting the integrity of the organism's genetic material during cell division.

By combining two genome-wide screens, the researchers were able to narrow down the dozens of genes identified by the first screen to just 17 that made both cut-offs -- a number small enough to be cost- and time-efficient to consider in some detail. Their report appears in the April issue of Molecular Biology of the Cell.

"Data created from new genome-scanning techniques can be overwhelming. Reading all there is to know about 50 genes to figure out what new knowledge may be lurking in the haystack is very difficult," says Forrest Spencer, Ph.D., associate professor in Hopkins' McKusick-Nathans Institute of Genetic Medicine. "But by overlapping information from two screens, we were able to figure out what Mother Nature was trying to tell us that wasn't too complicated for us to understand."

While the researchers had hoped their screens would reveal new genes and their functions, they instead identified genes previously linked to two other aspects of shepherding genetic material during cell division. Fifteen of the highlighted genes were already known to help ensure the accuracy of copied DNA and two help move chromosomes to opposite ends of the dividing cell.

But the researchers' results give these "old" genes new jobs, associating them with cohesion, the little-understood process of keeping a chromosome and its copy together until the cell is ready to split in two. If the "sister" chromosomes aren't kept together, both copies could end up on one side of the dividing cell. Another problem is that the copies could undergo extra rearrangements, risking loss of important genes.

"If there's no cohesion, the cell will die," says Spencer. "However, if the process sometimes works and sometimes doesn't, some c
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
22-Apr-2004


Page: 1 2 3

Related biology news :

1. Study: Genome-wide scanning unravels complex birth defect
2. March of Dimes statement on newborn screening report
3. Virus known for its photo ops makes its movie screen debut
4. Only 21 states offer newborn screening tests recommended by March of Dimes
5. New screening method turns up potential compound for treating anthrax
6. Gene-based screen sorts cancer cases, say Stanford researchers
7. Genetic screening study at Stanford IDs most aggressive adult leukemia strains
8. New, non-radioactive screen for antimalarial compounds
9. Genetic screening recommended to detect new neurodegenerative disorder in men over age 50
10. HPV testing could be future strategy for primary screening for cervical cancer
11. Newborn screening for certain genetic disorders has benefits and some drawbacks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... June 23, 2020 , ... ... today announced that the company has received ISO9001:2015 certification for the development ... research industries. The decision to pursue ISO9001 accreditation demonstrates Kemp’s commitment to ...
(Date:6/23/2020)... ... June 22, 2020 , ... The field of quantitation of large ... (LBA) have dominated this area. However, the use of mass spectrometry in this field ... necessitates the question “How do you choose which approach to use (LBA or MS)?” ...
(Date:6/23/2020)... ... ... In its June 22 online post, business and technology news platform Superb Crew ... and director of stem cell biotechnology company Asymmetrex . Superb Crew decided to ... 5 it would begin offering free tissue stem cell counting at its ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... SOMERSET, N.J (PRWEB) , ... July 29, 2020 ... ... editing company, and Catalent, the leading global provider of advanced delivery technologies, development, ... products, today announced that they have entered into a strategic partnership whereby Catalent ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... top radiation centers in 16 countries, has reached its 20th anniversary of worldwide ... in routine use at top universities including University of Pennsylvania, University of Michigan, ...
(Date:7/22/2020)... ... ... Join experts from Reed Tech , Gary Saner, Sr. Manager, Information Solutions Life ... webinar on Thursday, August 13, 2020 at 11am EDT (4pm BST/UK). , The ... medical devices, the NMPA has departments dealing with medical device registration (pre-market approvals) and ...
(Date:7/18/2020)... ... 16, 2020 , ... “We are thrilled to deliver this new technology to ... of its kind on the market and we were pleased that the IFT jury ... traditional cultured ingredients, creating a natural way to extend the shelf life and improve ...
Breaking Biology Technology:
Cached News: